851371-58-9

Basic information

• Product Name: [4,5'-BipyriMidin]-2'-aMine, 4'-(2-furanyl)-
• Synonyms: [4,5'-BipyriMidin]-2'-aMine, 4'-(2-furanyl)-;4'-(2-Furanyl)-[4,5'-bipyrimidin]-2'-amine;4'-(2-furyl)-4,5'-bipyrimidin-2'-amine
• CAS NO: 851371-58-9
• Molecular Formula: C12H9N5O
• Molecular Weight: 239.23276
• Mol File: 851371-58-9.mol

Chemical Properties

• Melting Point: 222℃
• Appearance: /
• Density: 1.344
• CAS DataBase Reference: [4,5'-BipyriMidin]-2'-aMine, 4'-(2-furanyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: [4,5'-BipyriMidin]-2'-aMine, 4'-(2-furanyl)-(851371-58-9)
• EPA Substance Registry System: [4,5'-BipyriMidin]-2'-aMine, 4'-(2-furanyl)-(851371-58-9)

Safety Data

• Hazardous Substances Data: 851371-58-9(Hazardous Substances Data)

Usage

Uses

Used in Medicinal Chemistry:
[4,5'-Bipyrimidin]-2'-amine, 4'-(2-furanyl)is used as a potential candidate in medicinal chemistry for its unique structural features and potential reactivity. [4,5'-Bipyrimidin]-2'-amine, 4'-(2-furanyl)may be explored for its possible applications in the development of new drugs or therapeutic agents.
Used in Organic Synthesis:
In the field of organic synthesis, [4,5'-Bipyrimidin]-2'-amine, 4'-(2-furanyl)is used as a building block or intermediate for the synthesis of more complex molecules. Its specific properties and reactivity may be harnessed to create novel compounds with various applications.

Upstream product

• 851371-59-0 3-(dimethylamino)-1-(2-furyl)-2-pyrimidin-4-ylprop-2-en-1-one 
• 50-01-1 guanidine hydrochloride 
• 593-85-1 diguanidine carbonate 
• 851371-60-3 1-(2-furyl)-2-(pyrimidin-4-yl)ethanone 
• 3438-46-8 4-Methylpyrimidine 

Relevant articles and documents

Discovery and characterization of 4′-(2-furyl)-N-pyridin-3-yl-4, 5′-bipyrimidin-2′-amine (LAS38096), a potent, selective, and efficacious A2B adenosine receptor antagonist

A novel series of N-heteroaryl 4′-(2-furyl)-4,5′-bipyrimidin- 2′-amines has been identified as potent and selective A2B adenosine receptor antagonists. In particular, compound 5 showed high affinity for the A2B receptor (Ki = 17 nM), good selectivity (IC50: A1 > 1000 nM, A2A > 2500 nM, A3 > 1000 nM), displayed a favorable pharmacokinetic profile in preclinical species, and showed efficacy in functional in vitro models.

Discovery of N-(5,6-diarylpyridin-2-yl)amide derivatives as potent and selective A2B adenosine receptor antagonists

The synthesis and SAR of a series of N-(5,6-diarylpyridin-2-yl)amide derivatives as potent A2B adenosine receptor antagonists is described. Several compounds showed good selectivity versus other adenosine receptors. The potent and selective analogue 9 was shown to have good oral bioavailability in the rat.

PYRIMIDIN-2-AMINE DERIVATES AND THEIR USE AS A2B ADENOSINE RECEPTOR ANTAGONISTS

This invention is directed to new potent and selective antagonists of the A2B adenosine receptor having the general formula (I) to processes for their preparation; to pharmaceutical compositions comprising them; and to their use in therapy.