85153-83-9

Basic information

• Product Name: propyl 5-oxo-L-prolinate
• Synonyms: propyl 5-oxo-L-prolinate;(S)-5-Oxo-2-pyrrolidinecarboxylic acid propyl ester;5-Oxo-L-proline propyl ester;Einecs 285-868-0
• CAS NO: 85153-83-9
• Molecular Formula: C₈H₁₃NO₃
• Molecular Weight: 171.19372
• EINECS: 285-868-0
• Mol File: 85153-83-9.mol

Chemical Properties

• Boiling Point: 323 °C at 760 mmHg
• Flash Point: 149.2 °C
• Appearance: /
• Density: 1.127 g/cm³
• CAS DataBase Reference: propyl 5-oxo-L-prolinate(CAS DataBase Reference)
• NIST Chemistry Reference: propyl 5-oxo-L-prolinate(85153-83-9)
• EPA Substance Registry System: propyl 5-oxo-L-prolinate(85153-83-9)

Safety Data

• Hazardous Substances Data: 85153-83-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Propyl 5-oxo-L-prolinate is used as an intermediate in the synthesis of pharmaceutical drugs for its unique chemical structure and properties. It may contribute to the development of new medications with improved efficacy and safety profiles.
Used in Agricultural Industry:
Propyl 5-oxo-L-prolinate is used as a building block in the synthesis of agrochemicals, such as pesticides and herbicides, due to its unique chemical properties. This allows for the creation of more effective and environmentally friendly agricultural products.
Used in Organic Chemistry:
Propyl 5-oxo-L-prolinate is used as a versatile building block for the synthesis of more complex molecules in organic chemistry. Its unique structure and properties make it a valuable component in the development of advanced organic compounds for various applications.
Used in Medicinal and Scientific Research:
Propyl 5-oxo-L-prolinate may have potential biological activities that make it useful for medicinal and scientific purposes. Its unique chemical structure and properties can be harnessed for research and development in the fields of medicine and biology, potentially leading to new discoveries and applications.

Upstream product

• 71-23-8 propan-1-ol 
• 98-79-3 L-Pyroglutamic acid 

Relevant articles and documents

Synthesis and bioactivities evaluation of L-pyroglutamic acid analogues from natural product lead

A series of L-pyroglutamic acid analogues from natural product lead were designed and synthesized, as well as their antifungal activities against Phytophthora infestans, neuritogenic activities, antibacterial activities and anti-inflammatory activities are described. The bioassays and SAR study showed that the majority of L-pyroglutamic acid esters have a significant antifungal activity against P. infestans, especially 2d and 2j demonstrated the best activities with EC50 values of 1.44 and 1.21 μg mL?1, which were about seven times that of commercial azoxystrobin (7.85 μg mL?1). Moreover, compounds 2e, 2g and 4d displayed anti-inflammatory activity against LPS-induced NO production in BV-2 microglial cells; neuritogenic activity in NGF-induced PC-12 cells is the same activity. This study demonstrates that compounds 2d and 2j are potential drugs to control P. infestans.

Cosmetic composition

A composition suitable for topical application to mammalian skin and hair for inducing, maintaining or increasing hair growth comprises a hair growth promoter chosen from glutamine derivatives and salts thereof. The composition preferably also comprises an activity enhancer which may be chosen from hair growth stimulants, penetration enhancers and cationic polymers.

Cosmetic composition containing DOPA derivatives

A composition for topical application to human hair or skin contains a chemical analogue of dihydroxyphenyl alanine (DOPA). This chemical analogue can be absorbed by skin or by a hair follicle and metabolised in-vivo, thus leading to the formation of melanin in skin or to the growth of melanin-pigmented hair. Consequently the composition can give controlled skin darkening to mimic sun-induced tanning or can bring about the growth of dar hair in place of the grey or white hair.

Cosmestic composition

A composition suitable for topical application to mammalian skin and hair for inducing, maintaining or increasing hair growth comprises a hair growth promoter chosen from glutamic acid derivatives and salts thereof. The composition preferably also comprises an activity enhancer which may be chosen from hair growth stimulants, penetration enhancers and cationic polymers.

Cosmetic composition

A composition suitable for topical application to mammalian skin or hair for inducing, maintaining or increasing hair growth comprises: (i) a first chemical inhibitor chosen from proteoglycanase inhibitors, glycosaminoglycanase inhibitors, glycosaminoglycan chain cellular uptake inhibitors or mixtures thereof; and (ii) a cosmetically acceptable vehicle for the chemical inhibitor; provided that when the first chemical inhibitor is a weak inhibitor, such that a 1 mM aqueous solution of the inhibitor reduces proteoglycanase activity, glycosaminoglycanase activity or cellular uptake of glycosaminoglycan chains, by from 5 to 50%, in accordance with at least one of the assay tests as herein described, then there is also present in the composition a second chemical inhibitor and/or an activity enhancer. When minoxidil is the sole chemical inhibitor, then the activity enhancer is a penetration enhancer chosen from a limited number of materials, including certain esters and cationic polymers. The total amount of chemical inhibitor present in the composition is sufficient to increase hair growth in the rat, when said composition is applied topically thereto, by at least 10% more than that obtainable using a control composition from which the said inhibitors have been omitted.