851985-99-4

Basic information

• Product Name: 6-hydroxy-5-methoxy-2-methyl-4(3H)-Pyrimidinone
• Synonyms: 6-hydroxy-5-methoxy-2-methyl-4(3H)-Pyrimidinone;6-Hydroxy-5-methoxy-2-methylpyrimidin-4(3H)-one
• CAS NO: 851985-99-4
• Molecular Formula: C6H8N2O3
• Molecular Weight: 156.13932
• Mol File: 851985-99-4.mol

Chemical Properties

• Appearance: /
• Density: 1.42±0.1 g/cm3(Predicted)
• PKA: 5.66±0.10(Predicted)
• CAS DataBase Reference: 6-hydroxy-5-methoxy-2-methyl-4(3H)-Pyrimidinone(CAS DataBase Reference)
• NIST Chemistry Reference: 6-hydroxy-5-methoxy-2-methyl-4(3H)-Pyrimidinone(851985-99-4)
• EPA Substance Registry System: 6-hydroxy-5-methoxy-2-methyl-4(3H)-Pyrimidinone(851985-99-4)

Safety Data

• Hazardous Substances Data: 851985-99-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Development:
6-hydroxy-5-methoxy-2-methyl-4(3H)-Pyrimidinone is used as a pharmaceutical candidate for its potential antioxidant, anti-inflammatory, and anticancer properties. Its unique structure allows it to be a promising target for the development of new drugs that can address various health conditions.
Used in Organic Synthesis:
In the field of organic synthesis, 6-hydroxy-5-methoxy-2-methyl-4(3H)-Pyrimidinone is used as a key intermediate or building block for the synthesis of more complex organic compounds. Its versatile functional groups enable it to be a valuable component in the creation of novel molecules with specific applications in various industries.

Upstream product

• 5018-30-4 dimethyl methoxymalonate 
• 124-42-5 acetamidine hydrochloride 
• 40924-27-4 diethyl methoxymalonate 

Relevant articles and documents

Pyrimidine Derivatives Which Are Antagonists Of Vitronectin Receptor

A subject of the invention is the compounds of formula (I); in which R1, R2, R3, R4 and R have the meanings indicated in the description, their preparation process, their use as medicaments having an antagonist activity on the vitronectin receptor and the pharmaceutical compositions containing them.

SUBSTITUTED NITROGEN-CONTAINING SIX-MEMBERED AMINO-HETEROCYCLES AS VANILLOID-1 RECEPTOR ANTAGONISTS FOR TREATING PAIN

The present invention provides a compound of formula (I): Y-J-NH-Z wherein: Y is a quinoline or isoquinoline optionally substituted with one or two substituents independently chosen from hydroxy, halogen, haloC1-4alkyl, C1-4alkyl, C1-4alkoxy, haloC1-4alkoxy, nitro and amino; J is pyridine, pyridazine, pyrazine, pyrimidine or triazine optionally substituted with one or two substituents independently chosen from hydroxy, halogen, haloC1-4alkyl, C1-4alkyl, C3-5cycloalkyl, C1-4alkoxy, hydroxyC1-4alkyl, cyano, hydroxy, C1-4cycloalkoxy, C1-4alkylthio, haloC1-4alkoxy, nitro, Q, (CH2)pQ, NR2R3, -(CH2)pNR2R3 and -O(CH2)pNR2R3; wherein J is substituted at positions meta to each other by NH and Y; and Z is phenyl or pyridyl optionally substituted with one or two substituents independently selected from halogen, haloC1-4alkyl, C1-4alkyl, C1-4alkoxy, haloC1-4alkoxy, nitro and amino; Q is phenyl, a five-membered heterocyclic ring containing one, two, three or four heteroatoms chosen from O, N and S, at most one heteroatom being O or S, or a six-membered heterocyclic ring containing one, two or three nitrogen atoms, optionally substituted by C1-4alkyl; each R2 and R3 is chosen from H and C1-4alkyl, or R2 and R3, together with the nitrogen atom to which they are attached, may form a six-membered ring optionally containing an oxygen atom or a further nitrogen atom, which ring is optionally substituted by C1-4alkyl or Q; p is 1, 2 or 3; or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising it; its use in methods of therapy; use of it for manufacturing medicaments; and methods of using it to treat diseases requiring administration of a VR1 antagonist such as pain, cough, GERD and depression.