40924-27-4

Upstream product

• 3938-96-3 ethyl 2-methoxyacetate 
• 105-58-8 Diethyl carbonate 
• 67-56-1 methanol 
• 5256-74-6 1,3-diethyl 2-diazopropanedioate 
• 5018-30-4 dimethyl methoxymalonate 
• 104-15-4 toluene-4-sulfonic acid 
• 6290-49-9 methyl methoxyacetate 
• 95-92-1 oxalic acid diethyl ester 
• 76429-94-2 diethyl diazirine-3,3-dicarboxylte 
• 64-17-5 ethanol 

Downstream Products

• 5018-31-5 methoxymalonic diamide 
• 751-74-6 methoxy-[6β-(2-phenyl-acetylamino)-penicillanoyloxy]-malonic acid diethyl ester 
• 851985-99-4 2-methyl-4,6-dihydroxy-5-methoxy-pyrimidine 
• 1095274-42-2 ethyl [5-(3,5-dichlorophenyl)-1,3,4-oxadiazol-2-yl](methyloxy)acetate 
• 1095274-41-1 ethyl 3-{2-[(3,5-dichlorophenyl)carbonyl]hydrazino}-2-(methyloxy)-3-oxopropanoate 
• 71720-62-2 6-hydroxy-5-methoxy-1H-pyrimidine-2,4-dione,sodium salt 
• 5018-30-4 dimethyl methoxymalonate 
• 35301-03-2 (2R,4S)-2,4-Dimethoxy-tridec-12-enoic acid methyl ester 
• 35301-05-4 (2S,4S)-2,4-Dimethoxy-tridec-12-enoic acid methyl ester 
• 35301-04-3 (2R,4R)-2,4-Dimethoxy-tridec-12-enoic acid methyl ester 
• 35301-02-1 (2S,4R)-2,4-Dimethoxy-tridec-12-enoic acid methyl ester 

Relevant academic research and scientific papers

NOVEL PYRIMIDINE COMPOUNDS AS MTOR AND P13K INHIBITORS

The present invention relates to pyrimidine compounds of formula (I): which are useful in treating mTOR kinase- or PI3K kinase-related diseases.

Experimental and theoretical analysis of the photochemistry and thermal reactivity of ethyl diazomalonate and its diazirino isomer. The role of molecular geometry in the decomposition of diazocarbonyl compounds

The photochemical or thermal decomposition of ethyl diazomalonate (1) or ethyl 3,3-diazirinedi-carboxylate in methanol solutions yields the O-H insertion product 6, while products of the Wolff rearrangement were not detected in both cases. The analysis of temperature-dependent 13C NMR spectra and the results of DFT B3LYP/6-311+G(3df,2p) and MP2/aug-cc-pVTZ//B3LYP/6-311+G(3df,2p) calculations allow us to conclude that diazodiester 1 predominantly exists in the Z,Z-conformation. In contrast, photolysis of the cyclic isopropylidene diazomalonate (3), which also has a Z,Z-configuration of the diazodicarbonyl moiety, results in a clean Wolff rearrangement. These observations allow us to conclude that the direction of the photodecomposition of diazomalonates is not controlled by the ground-state conformation. The quantum-mechanical analysis of the potential energy surfaces for the dediazotization of 1 and 3 suggests that the formation of a carbene as a discrete intermediate is controlled by the ability of the latter to adopt a conformation in which carbonyl groups are almost orthogonal to the carbene plane. The outcome of the photolysis of ethyl diazomalonate depends on the wavelength of irradiation. Irradiation with 254 nm light results in the loss of nitrogen and the formation of dicarboethoxycarbene (5, Φ254 = 0.31), while at longer wavelengths, diazirine 2 becomes an important byproduct (Φ350 = 0.09). This observation suggests that the formation of carbene 5 and isomerization to diazirine proceed from different electronically excited states of ethyl diazomalonate.

One-Pot synthesis of 5-Alkylthio-3H-1,2-dithiole-3-thiones: Advantages and scopes

The reaction of dialkyl malonate esters with P2S5/S8 in boiling xylene in the presence of 2-mercaptobenzothiazole/ZnO as catalyst produces 5-alkylthio-3H-1,2-dithiole-3-thiones as major identifiable product. Moderate yields were obtained with malonate esters of primary alcohols. The reaction fails with malonate esters of secondary alcohols. Regarding the substituent in position two, dialkyl malonates with groups such as CH3, Ph, CH2Ph, OCH3 and Cl afford the corresponding 4-substituted derivatives whereas with Br and NO2 do not give the expected products. Some mechanistic evidences are described.

Use of malonic acid derivative compounds for retarding plant growth

This invention relates to a method for retarding plant growth by applying to the plant an effective amount of a malonic acid derivative compound. This invention also relates to novel malonic acid derivative compounds and processes for the preparation thereof.

Synergistic plant growth regulator compositions

This invention relates to synergistic plant growth regulator compositions containing (1) an ethylene response or ethylene-type response inducing agent and (11) a malonic acid derivative compound. This invention also relates to the use of said compositions

Carba-acyclonucleoside antiherpetic agents

Ganciclovir 2 and 2'-carba-ganciclovir 5a are anti-viral agents differing structurally only in the replacement of an oxygen by a methylene group and yet expressing their biological properties along mechanistically independent pathways. Methoxy, hydroxy an

Process for the preparation of monomethyl-substituted methylene compounds

Monomethyl-substituted methylene compounds are obtained by reacting methylene compounds of the formula STR1 in which R1 and R2 independently of one another represent --CN, --CO--R3, --SO2 --R3 or --NO2 and R1 can additionally denote -aryl(R1)n, wherein R3 denotes --OH, alkyl, aralkyl, aryl, alkoxy, aralkoxy or aryloxy, or amino which is substituted by alkyl and/or aralkyl and/or aryl, and furthermore two radicals R3 together can be an alkylene group, the radical of an aliphatic diol or of an aliphatic diamine or the group --NH--CO--NH-- and n represents 1, 2 or 3, with formaldehyde and with hydrogen in the presence of a condensation catalyst and a hydrogenation catalyst at elevated temperature, the methylene compound being introduced into the liquid phase of the mixture of reactants in the course of the reaction.