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1-(6-Chloropyridin-3-yl)cyclopropanecarbonitrile, a chemical compound with the molecular formula C9H6ClN, is a cyclopropanecarbonitrile derivative featuring a chloropyridine substituent at the 1-position. This unique structure and its properties make it a valuable compound in the realm of medicinal chemistry and drug discovery.

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  • 854267-89-3 Structure
  • Basic information

    1. Product Name: 1-(6-Chloropyridin-3-yl)cyclopropanecarbonitrile
    2. Synonyms: 1-(6-Chloropyridin-3-yl)cyclopropanecarbonitrile;1-(6-CHLORO-3-PYRIDINYL)-CYCLOPROPANECARBONITRILE;CYCLOPROPANECARBONITRILE, 1-(6-CHLORO-3-PYRIDINYL)-;1-(6-chloropyridin-3-yl)cyclopropane-1-carbonitrile
    3. CAS NO:854267-89-3
    4. Molecular Formula: C9H7ClN2
    5. Molecular Weight: 178.61828
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 854267-89-3.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
    8. Solubility: N/A
    9. CAS DataBase Reference: 1-(6-Chloropyridin-3-yl)cyclopropanecarbonitrile(CAS DataBase Reference)
    10. NIST Chemistry Reference: 1-(6-Chloropyridin-3-yl)cyclopropanecarbonitrile(854267-89-3)
    11. EPA Substance Registry System: 1-(6-Chloropyridin-3-yl)cyclopropanecarbonitrile(854267-89-3)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 854267-89-3(Hazardous Substances Data)

854267-89-3 Usage

Uses

Used in Pharmaceutical Synthesis:
1-(6-Chloropyridin-3-yl)cyclopropanecarbonitrile is used as a key intermediate in the synthesis of pharmaceuticals for its potential to contribute to the development of new drugs. Its unique structure allows for the creation of molecules with specific therapeutic properties.
Used in Agrochemical Production:
In the agrochemical industry, 1-(6-Chloropyridin-3-yl)cyclopropanecarbonitrile is utilized as an intermediate in the production of various agrochemicals, potentially enhancing crop protection and management strategies.
Used in Medicinal Chemistry Research:
1-(6-Chloropyridin-3-yl)cyclopropanecarbonitrile serves as a valuable compound in medicinal chemistry research, where it can be used to explore new chemical spaces and investigate the interactions of this molecule with biological targets, thereby aiding in drug discovery processes.
Used in Organic Compound Production:
As an intermediate, 1-(6-Chloropyridin-3-yl)cyclopropanecarbonitrile may also be used in the synthesis of other organic compounds, expanding its utility across various chemical applications and industries.

Check Digit Verification of cas no

The CAS Registry Mumber 854267-89-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,5,4,2,6 and 7 respectively; the second part has 2 digits, 8 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 854267-89:
(8*8)+(7*5)+(6*4)+(5*2)+(4*6)+(3*7)+(2*8)+(1*9)=203
203 % 10 = 3
So 854267-89-3 is a valid CAS Registry Number.

854267-89-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 17, 2017

Revision Date: Aug 17, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-(6-chloropyridin-3-yl)cyclopropane-1-carbonitrile

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:854267-89-3 SDS

854267-89-3Relevant articles and documents

THIADIAZOLYL DERIVATIVES AS DNA POLYMERASE THETA INHIBITORS

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Paragraph 0688, (2020/12/11)

Disclosed herein are certain thiadiazolyl derivatives Formula (I): that inhibit DNA Polymerase Theta (Polθ) activity, in particular inhibit Polθ activity by inhibiting ATP dependent helicase domain activity of Polθ. Also, disclosed are pharmaceutical compositions comprising such compounds and methods of treating and/or preventing diseases treatable by inhibition of Polθ such as cancer, including homologous recombination (HR) deficient cancers.

LYSOPHOSPHATIDIC ACID RECEPTOR 1 (LPAR1) INHIBITOR COMPOUNDS

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Page/Page column 81, (2019/03/17)

A compound of formula (I) or a pharmaceutical salt thereof, use, methods for its preparation are described.

NEW AZIRIDINE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND THEIR USE AS ACETYL-COA CARBOXYLASE INHIBITORS

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Page/Page column 91, (2013/07/05)

The invention relates to new azetidine derivatives of the formula (I) wherein Ar1, Ar2, X, R, T and L are as defined in the description, to their use as medicaments, to methods for their therapeutic use and to pharmaceutical compositions containing them.

AZETIDINE DERIVATIVES

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Paragraph 0550; 0551; 0552; 0553, (2013/06/28)

Azetidine derivatives of which the following is exemplary and their use in the treatment of obesity, diabetes or dyslipidemia.

SUBSTITUTED 5-,6- AND 7-MEMBERED HETEROCYCLES, MEDICAMENTS CONTAINING SUCH COMPOUNDS, AND THEIR USE

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Page/Page column 66, (2012/01/06)

The present invention relates to compounds defined by formula I: wherein the variables A1, A2, Cy1 Cy2, Cy3, E, R1a, R1b, R2, R3, n, and Q are as defined herein, possessing valuable pharmacological activity. Particularly, the compounds are inhibitors of 11 β-hydroxysteroid dehydrogenase (HSD) 1 and thus are suitable for treatment and prevention of diseases which can be influenced by inhibition of this enzyme, such as metabolic diseases, in particular diabetes type 2, obesity, and dyslipidemia.

The discovery of MK-0674, an orally bioavailable cathepsin K inhibitor

Isabel, Elise,Bateman, Kevin P.,Chauret, Nathalie,Cromlish, Wanda,Desmarais, Sylvie,Duong, Le T.,Falgueyret, Jean-Pierre,Gauthier, Jacques Yves,Lamontagne, Sonia,Lau, Cheuk K.,Leger, Serge,LeRiche, Tammy,Levesque, Jean-Francois,Li, Chun Sing,Masse, Frederic,McKay, Daniel J.,Mellon, Christophe,Nicoll-Griffith, Deborah A.,Oballa, Renata M.,Percival, M. David,Riendeau, Denis,Robichaud, Joel,Rodan, Gideon A.,Rodan, Sevgi B.,Seto, Carmai,Therien, Michel,Truong, Vouy Linh,Wesolowski, Gregg,Young, Robert N.,Zamboni, Robert,Black, W. Cameron

scheme or table, p. 887 - 892 (2010/08/22)

MK-0674 is a potent and selective cathepsin K inhibitor from the same structural class as odanacatib with a comparable inhibitory potency profile against Cat K. It is orally bioavailable and exhibits long half-life in pre-clinical species. In vivo studies

CATHEPSIN CYSTEINE PROTEASE INHIBITORS

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Page/Page column 44, (2010/02/12)

This invention relates to a novel class of compounds which are cysteine protease inhibitors, including but not limited to, inhibitors of cathepsins K, L, S and B. These compounds are useful for treating diseases in which inhibition of bone resorption is indicated, such as osteoporosis.

Heterocyclic neophane analogs, processes for their preparation and their use as pest-combating agents

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, (2008/06/13)

Compounds of the formula (I) and their stereoisomers STR1 wherein A, B, C' and D independently of one another denote CH or N, in which at least one of the symbols A, B, C' or D must correspond to a nitrogen atom, X denotes CH2 or oxygen, R1 denotes a radical bonded to a carbon atom from the series comprising H, trialkylsilyl, halogen, nitro, cyano, alkenyl, alkynyl, amino, cycloalkyl, phenyl, phenxy, alkoxy, alkenyloxy, alkynyloxy, hydroxycarbonyl, alkylthio, cycloalkyloxy, alkylcarbonyl, alkoxycarbonyl, alkenyloxycarbonyl, alkynyloxycarbonyl, halogenoalkyl, alkoxyalkyl, halogenoalkoxy, halogenoalkylthio, halogenoalkoxyalkyl, alkylthioalkyl, alkoxyalkoxy, halogenoalkoxyalkoxy, alkenyloxyalkoxy, halogenoalkenyloxy, alkoxyalkylthio, alkylthioalkoxy, alkylthioalkylthio, halogenoalkoxycarbonyl, halogenoalkenyloxycarbonyl or dialkylamino or two radicals R1 when they are positioned ortho to one another together denote a methylenedioxy, ethylenedioxy or alkylene radical, R2 and R3 independently of one another denote alkyl, alkenyl or phenyl, or R2 and R3 denote an alkylene chain which--together with the quaternary carbon atom-forms an unsubstituted or fluorinesubstituted ring having three to six ring members, R4 denotes --H, F, --CN, --CCl3, --C CH, (C1 -C4)alkyl, --C--NH2, S R5 denotes pyridyl, furyl or thienyl which can all be substituted, phthalimidyl, dialkylmaleimidyl, thiophthalimidyl, dihydrophthalimidyl, tetrahydrophthalimidyl or substituted phenyl, or R4 and R5 --together with the carbon atom bridging them--denote an optionally substituted indanyl, cyclopentenoyl or cyclopentenyl radical and n denotes 0, 1 or 2, possess advantageous properties for combating pests, in particular insects and acarids. Furthermore, processes for the preparation of compounds of the formula I are described.

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