1-(6-Chloropyridin-3-yl)cyclopropanecarbonitrile

Base Information

• Chemical Name: 1-(6-Chloropyridin-3-yl)cyclopropanecarbonitrile
• CAS No.: 854267-89-3
• Molecular Formula: C₉H₇ClN₂
• Molecular Weight: 178.621
• Hs Code.: 2933399090
• Mol file: 854267-89-3.mol

Synonyms:1-(6-Chloropyridin-3-yl)cyclopropanecarbonitrile;1-(6-CHLORO-3-PYRIDINYL)-CYCLOPROPANECARBONITRILE;CYCLOPROPANECARBONITRILE, 1-(6-CHLORO-3-PYRIDINYL)-

Chemical Property of 1-(6-Chloropyridin-3-yl)cyclopropanecarbonitrile

Chemical Property:

• PSA: 36.68000
• LogP: 2.29018
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

1-(6-Chloropyridin-3-yl)cyclopropanecarbonitrile ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(6-Chloropyridin-3-yl)cyclopropanecarbonitrile

There total 3 articles about 1-(6-Chloropyridin-3-yl)cyclopropanecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

(6-chloro-pyridin-3-yl)-acetonitrile (39891-09-3) + 1-Bromo-2-chloroethane (107-04-0) → 1-(6-chloropyridin-3-yl)cyclopropanecarbonitrile (854267-89-3)

Guidance literature:

With N-benzyl-N,N,N-triethylammonium chloride; sodium hydroxide; at 60 ℃;

DOI:10.1016/j.bmcl.2009.12.083

Reference yield: 77.0%

(6-chloro-pyridin-3-yl)-acetonitrile (39891-09-3) + ethylene dibromide (106-93-4) → 1-(6-chloropyridin-3-yl)cyclopropanecarbonitrile (854267-89-3)

Guidance literature:

With sodium hydroxide; In water; at 50 ℃; for 16h;

Reference yield: 43.0%

→ 1-(6-chloropyridin-3-yl)cyclopropanecarbonitrile (854267-89-3)

Guidance literature:

upstream raw materials:

(6-chloro-pyridin-3-yl)-acetonitrile

1-Bromo-2-chloroethane

ethylene dibromide

Downstream raw materials:

1-(6-chloropyridin-3-yl)cyclopropanecarboxylic acid