854632-98-7

Basic information

• Product Name: 5-(benzyloxy)-3-iodo-1H-indazole
• Synonyms: 5-(benzyloxy)-3-iodo-1H-indazole;3-iodo-5-phenylmethoxy-2H-indazole
• CAS NO: 854632-98-7
• Molecular Formula: C₁₄H₁₁IN₂O
• Molecular Weight: 350.15441
• Mol File: 854632-98-7.mol

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: 5-(benzyloxy)-3-iodo-1H-indazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(benzyloxy)-3-iodo-1H-indazole(854632-98-7)
• EPA Substance Registry System: 5-(benzyloxy)-3-iodo-1H-indazole(854632-98-7)

Safety Data

• Hazardous Substances Data: 854632-98-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research:
5-(benzyloxy)-3-iodo-1H-indazole is used as a research compound for exploring its potential biological activities and applications in drug development. The introduction of a benzyl ether group and an iodine atom in the indazole molecule may enhance its biological activities and affinity for specific biological targets, making it a promising candidate for further study and potential development of new pharmaceuticals.
Used in Medicinal Chemistry:
5-(benzyloxy)-3-iodo-1H-indazole is used as a building block or intermediate in the synthesis of more complex molecules with potential therapeutic applications. Its unique chemical structure and properties can be utilized to design and develop new drugs targeting various diseases and conditions.

Upstream product

• 568596-29-2 1-(5-benzyloxyindazol-1-yl)ethanone 
• 15579-15-4 5-hydroxy-1H-indazole 
• 100-39-0 benzyl bromide 
• 78299-75-9 5-(benzyloxy)-1H-indazole 

Downstream Products

• 854633-04-8 5-benzyloxy-3-iodoindazole-1-carboxylic acid tert-butyl ester 
• 1338792-79-2 3-(5-(benzyloxy)-1H-indazol-3-yl)benzenesulfonamide 

Relevant articles and documents

Discovery of inhibitors of the mitotic kinase TTK based on N-(3-(3-sulfamoylphenyl)-1H-indazol-5-yl)-acetamides and carboxamides

TTK kinase was identified by in-house siRNA screen and pursued as a tractable, novel target for cancer treatment. A screening campaign and systematic optimization, supported by computer modeling led to an indazole core with key sulfamoylphenyl and acetamido moieties at positions 3 and 5, respectively, establishing a novel chemical class culminating in identification of 72 (CFI-400936). This potent inhibitor of TTK (IC50 = 3.6 nM) demonstrated good activity in cell based assay and selectivity against a panel of human kinases. A co-complex TTK X-ray crystal structure and results of a xenograft study with TTK inhibitors from this class are described.

KINASE INHIBITORS AND METHOD OF TREATING CANCER WITH SAME

The present teachings provide a compound represented by Structural Formula (I): or a pharmaceutically acceptable salt thereof. Also described are a pharmaceutical composition and method of use thereof.

Novel organophosphorus derivatives of indazoles and use thereof as medicinal products

The present invention relates in particular to novel chemical compounds, particularly to novel organophosphorus derivatives of indazoles, to the compositions containing them, and to the use thereof as medicinal products for treating cancers.