- Biocatalytic aminolysis of ethyl (S)-mandelate by lipase from Candida antarctica
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Enzymes play many roles in the advancement of biotechnology, discovery of new therapeutic agents and industrial processes. In this perspective, aminolysis reactions using lipase from Candida antarctica (CAL-B) were performed from ethyl (S)-mandelate and several aliphatic amines (45 °C, hexane, 3–6 h). By means of optimized conditions, amides with excellent isolated yields (60–97%) were synthetized. The biotechnological potential of CAL-B as a promising approach for the synthesis of organic compounds in a more sustainable, rapid, efficient and green chemistry perspective was verified on these results.
- Lima, Rafaely N.,Porto, André L.M.
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p. 157 - 163
(2017/07/12)
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- A two-step chemical/chiroptical method for determining absolute configurations of α-hydroxy acids
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A general, chemical/chiroptical approach based on the CD exciton chirality method has been developed to determine the absolute configuration of α-hydroxy acids. This approach consists of amidation of the carboxyl group with ethanolamine followed by deriva
- Rickman, Barry H.,Matile, Stefan,Nakanishi, Koji,Berova, Nina
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p. 5041 - 5064
(2007/10/03)
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