855763-77-8

Basic information

• Product Name: ethyl2-methylquinoline-6-carboxylate
• Synonyms: ethyl2-methylquinoline-6-carboxylate;ethyl4-hydroxy-2-methylquinoline-6-carboxylate;2-Methylquinoline-6-carboxylic acid ethyl ester;2-Methyl-6-quinolinecarboxylic acid ethyl ester
• CAS NO: 855763-77-8
• Molecular Formula: C₁₃H₁₃NO₂
• Molecular Weight: 215.25
• Product Categories: Heterocyclic Compounds;Quinolines;quinoline
• Mol File: 855763-77-8.mol

Chemical Properties

• Boiling Point: 334.4 °C at 760 mmHg
• Flash Point: 156.1 °C
• Appearance: /Solid
• Density: 1.148 g/cm³
• Vapor Pressure: 0.000128mmHg at 25°C
• Refractive Index: 1.591
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 4.95±0.43(Predicted)
• CAS DataBase Reference: ethyl2-methylquinoline-6-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl2-methylquinoline-6-carboxylate(855763-77-8)
• EPA Substance Registry System: ethyl2-methylquinoline-6-carboxylate(855763-77-8)

Safety Data

• Hazardous Substances Data: 855763-77-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Ethyl 2-methylquinoline-6-carboxylate is used as an active pharmaceutical ingredient for the development of new drugs. Its unique molecular structure and properties make it a promising candidate for the treatment of various diseases and conditions.
Used in Medicinal Chemistry:
Ethyl 2-methylquinoline-6-carboxylate is utilized as a key intermediate in the synthesis of various medicinal compounds. Its presence in the molecular structure can enhance the biological activity and therapeutic potential of the resulting compounds.
Used in Chemical-based Industries:
Ethyl 2-methylquinoline-6-carboxylate is employed as a versatile building block in the synthesis of a wide range of chemical products. Its reactivity and compatibility with other chemical entities make it suitable for various industrial applications, such as the production of dyes, pigments, and other specialty chemicals.

InChI:InChI=1/C13H13NO2/c1-3-16-13(15)11-6-7-12-10(8-11)5-4-9(2)14-12/h4-8H,3H2,1-2H3

Upstream product

• 64-17-5 ethanol 
• 94-09-7 p-aminoethylbenzoate 
• 635-80-3 quinaldine-6-carboxylic acid 

Downstream Products

• 37535-43-6 2-methylquinoline-6-carboxamide 

Relevant articles and documents

Assembly of Diversely Substituted Quinolines via Aerobic Oxidative Aromatization from Simple Alcohols and Anilines

An aerobic oxidative aromatization of simple aliphatic alcohols and anilines under the Pd(OAc)2/2,4,6-Collidine/Br?nsted acid catalytic system has been established, providing a direct approach for the preparation of diverse substituted quinoline derivatives in high yields with wide functional group tolerance. Practically, the protocol can be easily scaled up to gram-scale and was utilized in the concise formal synthesis of a promising herbicide candidate.

Preparation method of quinoline derivative

The invention provides a preparation method of a quinoline derivative. The method includes the steps of: in the presence of an oxidizing agent, adding a catalyst, then adding aniline or aromatic amine with different substituents, at the same time adding alcohol for reaction so as to prepare the quinoline derivative by one step. Specifically, the catalyst comprises a metal catalyst, an assistant catalyst I and an assistant catalyst II; the metal catalyst is a transition metal catalyst; the assistant catalyst I is an alkaline nitrogen-containing ligand; and the assistant catalyst II is an acidic compound. The quinoline derivative prepared by the method provided by the invention has stable performance and high purity. And the preparation method of the quinoline derivative can prepare quinoline, 2-methylquinoline, 8-hydroxyquinoline quinoline and other derivatives by one-step reaction, and the preparation method is simple and practicable. The preparation process does not produce new "three wastes", is environment-friendly, and provides a green and environment-friendly synthesis method. The preparation method has the characteristics of few raw material variety, little reaction equipment, few preparation step and low cost, and is more suitable for industrial production.