Glutathione potentiates cGMP synthesis induced by the two phenylfuroxancarbonitrile isomers in RFL-6 cells

DOI: 10.1016/0960-894X(96)00479-9

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 2607 - 2612 (1996)

Update date:2022-07-30

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Authors:

Di Stilo

Cena Cena

Gasco Gasco

Ghigo Ghigo

Bosia Bosia

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Article abstract of DOI:10.1016/0960-894X(96)00479-9

The cellular mechanism of bioactivation underlying guanylate cyclase activation by the pair of phenylfuroxancarbonitrile isomers 2a, b was investigated. In cultured rat lung fibroblast (RFL-6 cells) it was principally dependent on intracellular thiols.

Full text of DOI:10.1016/0960-894X(96)00479-9

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