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2-Fluoro-3-pyridinemethanamine is a chemical compound with the molecular formula C6H6FN2. It is a derivative of pyridine, featuring a six-membered heterocyclic ring with one nitrogen atom. Characterized by the presence of a fluoro group and an amine functional group attached to the pyridine ring, this compound is known for its structural features and reactivity, making it a valuable building block in organic synthesis and a promising intermediate in the development of pharmaceuticals and agrochemicals.

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  • 859164-64-0 Structure
  • Basic information

    1. Product Name: 2-FLUORO-3-PYRIDINEMETHANAMINE
    2. Synonyms: RARECHEM AL BW 2476;2-FLUORO-3-PYRIDINEMETHANAMINE;(2-FLUOROPYRIDIN-3-YL)METHANAMINE;2-fluoro-3-pyridineMethanaMine dihydrochloride;(2-Fluoropyridin-3-yl)MethanaMine hydrochloride;2-Fluoro-3-pyridinemethanamine,hydrochloride;(2-Fluoropyridin-3-yl)methanamine dihydrochloride;2-fluoro-3-(aminomethyl)pyridine hydrochloride
    3. CAS NO:859164-64-0
    4. Molecular Formula: C6H7FN2
    5. Molecular Weight: 126.13
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 859164-64-0.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 225.6°C at 760 mmHg
    3. Flash Point: 90.2°C
    4. Appearance: /
    5. Density: 1.18g/cm3
    6. Vapor Pressure: 0.0858mmHg at 25°C
    7. Refractive Index: 1.525
    8. Storage Temp.: Inert atmosphere,Room Temperature
    9. Solubility: N/A
    10. CAS DataBase Reference: 2-FLUORO-3-PYRIDINEMETHANAMINE(CAS DataBase Reference)
    11. NIST Chemistry Reference: 2-FLUORO-3-PYRIDINEMETHANAMINE(859164-64-0)
    12. EPA Substance Registry System: 2-FLUORO-3-PYRIDINEMETHANAMINE(859164-64-0)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 859164-64-0(Hazardous Substances Data)

859164-64-0 Usage

Uses

Used in Pharmaceutical Industry:
2-Fluoro-3-pyridinemethanamine is used as a key intermediate in the synthesis of various pharmaceuticals for the treatment of different medical conditions. Its unique structural features and reactivity contribute to the development of novel drug candidates with potential therapeutic benefits.
Used in Agrochemical Industry:
In the agrochemical sector, 2-Fluoro-3-pyridinemethanamine serves as an essential building block in the creation of new agrochemicals. Its properties allow for the design of innovative compounds with improved efficacy and selectivity in crop protection and pest management.
Used in Organic Synthesis:
2-Fluoro-3-pyridinemethanamine is utilized as a versatile reagent in organic synthesis, enabling the production of a wide range of chemical compounds. Its structural features and reactivity make it an important component in the synthesis of complex organic molecules for various applications, including materials science, chemical research, and specialty chemicals.

Check Digit Verification of cas no

The CAS Registry Mumber 859164-64-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,5,9,1,6 and 4 respectively; the second part has 2 digits, 6 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 859164-64:
(8*8)+(7*5)+(6*9)+(5*1)+(4*6)+(3*4)+(2*6)+(1*4)=210
210 % 10 = 0
So 859164-64-0 is a valid CAS Registry Number.
InChI:InChI=1S/C6H7FN2/c7-6-5(4-8)2-1-3-9-6/h1-3H,4,8H2

859164-64-0Downstream Products

859164-64-0Relevant articles and documents

Catalytic Staudinger Reduction at Room Temperature

Lenstra, Danny C.,Wolf, Joris J.,Mecinovi?, Jasmin

, p. 6536 - 6545 (2019/05/24)

We report an efficient catalytic Staudinger reduction at room temperature that enables the preparation of a structurally diverse set of amines from azides in excellent yields. The reaction is based on the use of catalytic amounts of triphenylphosphine as a phosphine source and diphenyldisiloxane as a reducing agent. Our catalytic Staudinger reduction exhibits a high chemoselectivity, as exemplified by reduction of azides over other common functionalities, including nitriles, alkenes, alkynes, esters, and ketones.

Sustainable organophosphorus-catalysed Staudinger reduction

Lenstra, Danny C.,Lenting, Peter E.,Mecinovi?, Jasmin

, p. 4418 - 4422 (2018/10/17)

A highly efficient and sustainable catalytic Staudinger reduction for the conversion of organic azides to amines in excellent yields has been developed. The reaction displays excellent functional group tolerance to functionalities that are otherwise prone to reduction, such as sulfones, esters, amides, ketones, nitriles, alkenes, and benzyl ethers. The green nature of the reaction is exemplified by the use of PMHS, CPME, and a lack of column chromatography.

CB1 MODULATOR COMPOUNDS

-

Page/Page column 59, (2008/06/13)

Novel compounds of structural formula (I) are disclosed. As modulators of the Cannabinoid-1 (CB1) receptor, these compounds are useful in the treatment, prevention and suppression of diseases mediated by the CB1 receptor. As such, compounds of the present invention are useful as in the treatment, prevention and suppression of psychosis, memory deficits, cognitive disorders, migraine, neuropathy, neuro-inflammatory disorders (e.g., multiple sclerosis, Guillain-Barre syndrome and the inflammatory sequelae of viral encephalitis), cerebral vascular accidents, head trauma, anxiety disorders, stress, epilepsy, Parkinson's disease, and schizophrenia. The compounds are also useful for the treatment of substance abuse disorders, particularly to opiates, alcohol, and nicotine. The compounds are also useful for the treatment of obesity or eating disorders associated with excessive food intake and complications associated therewith.

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