131747-55-2

Usage

Uses

Used in Pharmaceutical Industry:
2-Fluoro-3-(hydroxymethyl)pyridine is used as a key intermediate for the synthesis of various pharmaceutical compounds. Its unique structure allows for the development of new drugs with improved therapeutic properties and reduced side effects.
Used in Agrochemical Industry:
In the agrochemical sector, 2-Fluoro-3-(hydroxymethyl)pyridine serves as a crucial building block for the creation of novel agrochemicals, such as pesticides and herbicides. Its incorporation into these products can enhance their effectiveness and selectivity, leading to more sustainable agricultural practices.
Used as a Reagent in Organic Synthesis:
2-Fluoro-3-(hydroxymethyl)pyridine is employed as a reagent in the production of a wide range of organic compounds. Its presence in various chemical reactions facilitates the synthesis of complex molecules, contributing to the advancement of organic chemistry and the development of new materials and compounds.

InChI:InChI=1/C6H6FNO/c7-6-5(4-9)2-1-3-8-6/h1-3,9H,4H2

Upstream product

• 36404-90-7 2-fluoropyridine-3-carboxaldehyde 
• 2369-18-8 2-fluoro-3-methylpyridine 
• 1603-40-3 3-methylpyridin-2-ylamine 
• 315180-14-4 3-(chloromethyl)-2-fluoropyridine 
• 393-55-5 2-fluoronicotinic acid 

Downstream Products

• 30412-42-1 3-(bromomethyl)-2-fluoropyridine 
• 1026394-81-9 C₂₀H₂₁Cl₂N₃O 
• 1027431-46-4 C₂₀H₂₁Cl₂N₃S 
• 1026309-05-6 C₂₀H₂₁Cl₂N₃O₂S 
• 1027540-38-0 C₂₁H₂₃Cl₂N₃O 
• 1318800-67-7 C₂₀H₂₂Cl₂N₄O₂S 
• 1028315-05-0 C₂₁H₂₅ClN₄O₂S 
• 1187465-23-1 5-chloro-N-[(2Z)-3-[(2-fluoropyridin-3-yl)methyl]-5-methyl-1,3-thiazol-2(3H)-ylidene]-2-methoxybenzamide 
• 859164-64-0 2-fluoro-3-(aminomethyl)pyridine hydrochloride 
• 108338-05-2 2-Fluoro-2',6'-dimethyl-1',4'-dihydro-[3,4']bipyridinyl-3',5'-dicarboxylic acid 5'-[2-(benzyl-methyl-amino)-ethyl] ester 3'-methyl ester 
• 315180-14-4 3-(chloromethyl)-2-fluoropyridine 
• 36404-90-7 2-fluoropyridine-3-carboxaldehyde 

Relevant academic research and scientific papers

Efficient pyridinylmethyl functionalization: Synthesis of 10,10-bis[(2-fluoro-4-pyridinyl)methyl]-9(10H)-anthracenone (DMP 543), an acetylcholine release enhancing agent

2-Fluoro-4-methylpyridine (3) is efficiently functionalized by chlorination, hydrolysis and methane-sulfonylation into the novel alkylating agent 7. This mesylate is used for the bisalkylation of anthrone under carefully defined conditions to prepare the cognition enhancer drug candidate 1. This process proceeds in up to 37% overall yield and is adaptable for large scale synthesis.

SUBSTITUTED GUANIDINE DERIVATIVE

The present invention provides a compound of general formula (I) (wherein, R1, X, p and q are as described in the present description and claims), or a pharmacologically acceptable salt thereof, and a pharmaceutical composition containing that compound.

Substituted purinon derivatives and medicinal use thereof

The invention relates to substituted purinon derivatives represented by formula (I), and pharmaceutically acceptable salts, isomers, prodrugs and medicinal compositions thereof. Above compounds are stimulants of soluble guanylate cyclase. In the formula (I), R1 represents a thienyl group or a substituted pyridyl group, R2 represents -NH2 or -NHCH3, and R3 represents hydrogen or a C1-C4 alkyl group. The invention also discloses a preparation method of the compounds and an application of the compounds as medicines, especially an application as cardiovascular disease treatment medicines.

Substituted pyrazolopyridine derivatives and medicinal use thereof

The invention relates to substituted pyrazolopyridine derivatives represented by formula (I), and pharmaceutically acceptable salts, isomers, prodrugs and medicinal compositions thereof. Above compounds are stimulants of soluble guanylate cyclase. In the formula (I), R1 represents a thienyl group or a substituted pyridyl group, R2 represents -NH2, -NHCH3 or -NHC(=O)CH(CH3)2, R3 represents hydrogenor a C1-C4 alkyl group, and R4 represents a C1-C6 alkyl group. The invention also discloses a preparation method of the compounds and an application of the compounds as medicines, especially an application as cardiovascular disease treatment medicines, such as anti-pulmonary arterial hypertension medicines.

Modular Route to Azaindanes

A convergent radical based route to azaindanes is described, relying on the degenerative addition transfer of various substituted S-(pyridylmethyl)-O-ethyl dithiocarbonates (xanthates) to functional alkenes followed by radical cyclization onto the pyridine ring activated by protonation with trifluoroacetic acid. In one case, a richly decorated cyclohepta[b]pyridine could be assembled swiftly by allowing the first adduct to N-phenylmaleimide to undergo addition to N-allylphthalimide prior to cyclization.

HETEROCYCLYL PYRAZOLOPYRIMIDINE ANALOGUES AS JAK INHIBITORS

The present invention relates to compounds of formula (I) wherein X1 to X5, Y, Z1 to Z3, and R have the meaning as cited in the description and the claims. Said compounds are useful as JAK inhibitors for the treatment or prophylaxis of immunological, inflammatory, autoimmune, allergic disorders, and immunologically-mediated diseases. The invention also relates to pharmaceutical compositions including said compounds, the preparation of such compounds as well as the use as medicaments.

METHYL SULFANYL PYRMIDMES USEFUL AS ANTIINFLAMMATORIES, ANALGESICS, AND ANTIEPILEPTICS

The present invention relates to pyrimidine derivatives of Formula (Ia) and (Ib) (including tautomers, isomers, prodrugs, and pharmaceutically acceptable salts thereof). Said compounds are useful in the treatment of pain (such as neuropathic pain), inflammation, and epilepsy (by acting as anticonvulsants). Methods of medical treatment making use of said compounds, as well as additional compounds of Formula (IIa) and (IIb), are also disclosed.

BETA-AMYLOID PROTEIN PRODUCTION/SECRETION INHIBITORS

Provided are novel compounds having an inhibitory activity against production or secretion of β-amyloid protein. They embrace compounds represented by the following formula (1): and capable of being replaced with a variety of substituents; and salts thereof, and solvates of any one of them.

Potentiators of glutamate receptors

The present invention relates to potentiators of metabotropic glutamate receptor function and specifically provides compounds of formula I, compositions thereof and methods of using the same.