862201-35-2

Basic information

• Product Name: 4-(P-BROMOPHENYL)-2-PHENYLPYRROLE
• Synonyms: 4-(P-BROMOPHENYL)-2-PHENYLPYRROLE;4-(4-Bromophenyl)-2-phenylpyrrole
• CAS NO: 862201-35-2
• Molecular Formula: C₁₆H₁₂BrN
• Molecular Weight: 298.18
• Mol File: 862201-35-2.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-(P-BROMOPHENYL)-2-PHENYLPYRROLE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(P-BROMOPHENYL)-2-PHENYLPYRROLE(862201-35-2)
• EPA Substance Registry System: 4-(P-BROMOPHENYL)-2-PHENYLPYRROLE(862201-35-2)

Safety Data

• Hazardous Substances Data: 862201-35-2(Hazardous Substances Data)

Upstream product

• 23565-63-1 1-(4-bromophenyl)-3-phenylpropynone 
• 219607-51-9 3-(4-bromophenyl)-4-nitro-1-phenylbutan-1-one 
• 1122-91-4 4-bromo-benzaldehyde 
• 22966-09-2 (2E)-3-(4-bromophenyl)-1-phenylprop-2-en-1-one 
• 98-86-2 acetophenone 

Relevant articles and documents

Base-promoted ring-closing carbonyl-allene metathesis for the synthesis of 2,4-disubstituted pyrroles

A base-promoted ring-closing carbonyl-allene metathesis reaction of N-allenyl β-enaminones (generated in situ from N-propargyl β-enaminones) gives 2,4-disubstituted pyrroles with cleavage of the C(sp)-C(sp3) bond. This transition metal-free procedure generates 1 equiv. of acetic acid as the sole byproduct. A preliminary mechanistic study supports a stepwise [2 + 2] cycloaddition/retro [2 + 2] reaction pathway.

Preparation method of 2,4-di-substituted pyrrole derivative

The invention discloses a preparation method of a 2,4-di-substituted pyrrole derivative. The reaction equation is shown in the description. By adopting the method, a pyrrole derivative with a plurality of substituents which is difficult to obtain with other methods can be synthesized.

Reaction between 4-Nitro-1,3-diarylbutan-1-ones and Ammonium Acetate in the Presence of Morpholine and Sulfur: An Efficient Synthesis of 2,4-Diarylpyrroles

An efficient synthesis of 2,4-diarylpyrroles is described. Heating a mixture of a 4-nitro-1,3-diarylbutan-1-one and ammonium acetate in the presence of morpholine and sulfur afforded the corresponding 2,4-diarylpyrroles in excellent yields.

A modular synthesis of unsymmetrical tetraarylazadipyrromethenes

A stepwise route to unsymmetrical tetraarylazadipyrromethenes by a condensation of 2,4-diaryl-5-nitroso-pyrroles with 2,4-diarylpyrroles is described. This modular building-block approach allows for the introduction of up to four different aryl substituents on the azadipyrromethene and is tolerant of a varied substituent set. An efficient synthesis of the 2,4-diarylpyrroles building blocks from 1,3-diaryl-4-nitro-butan-1-ones by nitro hydrolysis to a keto-aldehyde and subsequent ammonia condensation reaction has been achieved. The facile conversion of 2,4-diarylpyrroles into their α-nitroso analogues by their reaction with sodium nitrite generated the second building block required for the synthesis.