863401-75-6Relevant articles and documents
1-(4-Amino-phenyl)-pyrrolidin-3-yl-amine and 6-(3-amino-pyrrolidin-1-yl)- pyridin-3-yl-amine derivatives as melanin-concentrating hormone receptor-1 antagonists
Huang, Charles Q.,Baker, Tracy,Schwarz, David,Fan, Jun,Heise, Christopher E.,Zhang, Mingzhu,Goodfellow, Val S.,Markison, Stacy,Gogas, Kathleen R.,Chen, Takung,Wang, Xiao-Chuan,Zhu, Yun-Fei
, p. 3701 - 3706 (2007/10/03)
Derivatives of 1-(4-amino-phenyl)-pyrrolidin-3-yl-amine and 6-(3-amino-pyrrolidin-1-yl)-pyridin-3-yl-amine were identified as potent and functionally active MCH-R1 antagonists. One compound with Ki = 2.3 nM demonstrated good oral bioavailabilit