864059-66-5

Basic information

• Product Name: 2,3-Difluoro-4'-methyl-1,1'-Biphenyl
• Synonyms: 2,3-Difluoro-4'-methyl-1,1'-Biphenyl;2,3-Difluoro-4'-Methylbiphenyl
• CAS NO: 864059-66-5
• Molecular Formula: C13H10F2
• Molecular Weight: 204
• Mol File: 864059-66-5.mol

Chemical Properties

• Boiling Point: 270.9 °C at 760 mmHg
• Flash Point: 97.3 °C
• Appearance: /
• Density: 1.138 g/cm³
• CAS DataBase Reference: 2,3-Difluoro-4'-methyl-1,1'-Biphenyl(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-Difluoro-4'-methyl-1,1'-Biphenyl(864059-66-5)
• EPA Substance Registry System: 2,3-Difluoro-4'-methyl-1,1'-Biphenyl(864059-66-5)

Safety Data

• Hazardous Substances Data: 864059-66-5(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
2,3-Difluoro-4'-methyl-1,1'-Biphenyl is used as a building block in the preparation of various pharmaceuticals, agrochemicals, and materials. Its specific molecular structure makes it a valuable component in the synthesis of complex organic compounds.
Used in Organic Electronics and Optoelectronic Devices:
Due to its unique molecular structure and electronic properties, 2,3-Difluoro-4'-methyl-1,1'-Biphenyl has potential applications in the field of organic electronics and optoelectronic devices, where it can contribute to the development of advanced technologies.
Used in Research:
2,3-Difluoro-4'-methyl-1,1'-Biphenyl also serves as a research tool in the study of organic chemistry and material science, aiding scientists in understanding the properties and behavior of similar compounds and their potential applications in various fields.

Upstream product

• 1489-53-8 1,2,3-trifluorobenzene 
• 4294-57-9 para-methylphenylmagnesium bromide 
• 106-38-7 para-bromotoluene 
• 367-11-3 ortho-difluorobenzene 
• 121219-16-7 (2,3-difluorophenyl)boronic acid 
• 6418-38-8 2,3-difluorophenol 

Relevant articles and documents

Iron-catalyzed coupling of aryl sulfamates and aryl/vinyl tosylates with aryl grignards

The iron-catalyzed coupling of aryl sulfamates and tosylates with aryl Grignard reagents is reported for the first time. The methodology employs air-stable, low-cost FeF3·3H2O and the N-heterocyclic carbene ligand IPr·HCl as the preligand to form a long-lived catalyst upon treatment with aryl Grignards. The reaction provides a range of cross-coupled products in good-to-excellent yields. In contrast to previous reports with aryl chlorides, these reactions proceed with low levels of Grignard homocoupling regardless of the iron source.

Green synthesis of fluorinated biaryl derivatives via thermoregulated ligand/palladium-catalyzed Suzuki reaction

Fluorinated compounds have attracted considerable attention in pharmaceuticals, agrochemicals and material science due to their unique physical properties. This paper reports an efficient and environmentally benign protocol for the Suzuki reaction of aryl halides with fluorinated arylboronic acids over a thermoregulated ligand/palladium catalyst using water as sole medium, affording a variety of fluorinated biaryls, including fluorinated liquid crystals, in excellent yields. The catalyst could be recycled four times with high activity. The active catalyst was proved to be a palladium/ligand complex via a mercury-poisoning test.

Catalytic intermolecular direct arylation of perfluorobenzenes

Penta-, tetra-, tri-, and difluorobenzenes undergo direct arylation with a wide range of arylhalides in high yield. Inverse reactivity is observed compared to the common electrophilic aromatic substitution pathway since electron-deficient, C-H acidic aren

Nickel- and palladium-catalyzed cross-coupling reaction of polyfluorinated arenes and alkenes with grignard reagents

The cross-coupling reaction of fluorobenzene with an aryl Grignard reagent has been reinvestigated which revealed that the reaction readily proceeds under ordinary conditions using a catalytic amount of NiCl2(dppp) even at room temperature. The use of nickel catalysts and Grignard reagent is essential for the activation of the carbon-fluorine bond. The palladium catalyst is also effective for the 1,2-difluorobenzene and trifluorobenzenes to selectively produce the corresponding mono-coupled products while the nickel-based catalyst system affords a mixture of the mono-coupled product and di- or tri-coupled product. Georg Thieme Verlag Stuttgart.

Process for the preparation of 2,3-difluorobenzenes

1,4-disubstituted 2,3-difluorobenzenes according to formula I are suitable as intermediates for the synthesis of liquid crystalline compounds.