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2,4-Pyrimidinediamine, 5-[5-iodo-4-methoxy-2-(1-methylethyl)phenoxy]is a chemical compound with a unique structure that features a pyrimidinediamine core and a substituted phenoxy group. 2,4-Pyrimidinediamine, 5-[5-iodo-4-methoxy-2-(1-methylethyl)phenoxy]exhibits specific biological activities and properties that make it suitable for various applications in different industries.

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  • 2,4-Pyrimidinediamine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]-

    Cas No: 865305-30-2

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  • 865305-30-2 Structure
  • Basic information

    1. Product Name: 2,4-PyriMidinediaMine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]-
    2. Synonyms: 2,4-PyriMidinediaMine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]-;AF 353;Ro 4;5-{[5-iodo-2-(1-Methylethyl)-4-(Methyloxy)phenyl]oxy}-2,4-pyriMidinediaMine;5-[5-Iodo-4-methoxy-2-(1-methylethyl)phenoxy]-2,4-pyrimidinediamine;AF-353 (Ro-4)
    3. CAS NO:865305-30-2
    4. Molecular Formula: C14H17IN4O2
    5. Molecular Weight: 400.21485
    6. EINECS: N/A
    7. Product Categories: Inhibitors
    8. Mol File: 865305-30-2.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 510.2±60.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.619±0.06 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. PKA: 6.89±0.10(Predicted)
    10. CAS DataBase Reference: 2,4-PyriMidinediaMine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]-(CAS DataBase Reference)
    11. NIST Chemistry Reference: 2,4-PyriMidinediaMine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]-(865305-30-2)
    12. EPA Substance Registry System: 2,4-PyriMidinediaMine, 5-[5-iodo-4-Methoxy-2-(1-Methylethyl)phenoxy]-(865305-30-2)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 865305-30-2(Hazardous Substances Data)

865305-30-2 Usage

Uses

Used in Pharmaceutical Industry:
2,4-Pyrimidinediamine, 5-[5-iodo-4-methoxy-2-(1-methylethyl)phenoxy]is used as a pharmaceutical agent for its potential therapeutic effects. 2,4-Pyrimidinediamine, 5-[5-iodo-4-methoxy-2-(1-methylethyl)phenoxy]-'s unique structure allows it to interact with specific biological targets, such as receptors or enzymes, modulating their activity and leading to desired pharmacological effects.
Used in Chemical Research:
In the field of chemical research, 2,4-Pyrimidinediamine, 5-[5-iodo-4-methoxy-2-(1-methylethyl)phenoxy]serves as a valuable compound for studying the structure-activity relationships of various biologically active molecules. Its unique features can provide insights into the design and development of new drugs and other bioactive compounds.
Used in Material Science:
2,4-Pyrimidinediamine, 5-[5-iodo-4-methoxy-2-(1-methylethyl)phenoxy]can also be utilized in material science for the development of novel materials with specific properties. Its unique structure and functional groups can be exploited to create materials with tailored characteristics for various applications, such as sensors, catalysts, or advanced materials for electronics and energy storage.

Check Digit Verification of cas no

The CAS Registry Mumber 865305-30-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,6,5,3,0 and 5 respectively; the second part has 2 digits, 3 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 865305-30:
(8*8)+(7*6)+(6*5)+(5*3)+(4*0)+(3*5)+(2*3)+(1*0)=172
172 % 10 = 2
So 865305-30-2 is a valid CAS Registry Number.

865305-30-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-(5-iodo-4-methoxy-2-propan-2-ylphenoxy)pyrimidine-2,4-diamine

1.2 Other means of identification

Product number -
Other names AF 353

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:865305-30-2 SDS

865305-30-2Relevant articles and documents

METHODS AND COMPOSITIONS FOR TREATING DISEASES AND CONDITIONS

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Paragraph 185, (2016/01/25)

Provided herein include methods and compositions for treating diseases or conditions. In some embodiments provided are methods for treating one or more diseases or conditions selected from the group consisting of hypertension, heart failure, dyspnea, and

Methods of Using Diaminopyrimidine P2X3 and P2X 2/3 Receptor Modulators for Treatment of Acute and Sub-Acute Cough, Urge to Cough and Chronic Cough, in Respiratory Diseases

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Paragraph 0155; 0156, (2015/03/04)

Methods for treating cough, chronic cough and urges to cough associated with respiratory diseases with a P2X3 and/or a P2X2/3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of Formu

Identification and SAR of novel diaminopyrimidines. Part 1: The discovery of RO-4, a dual P2X3/P2X2/3 antagonist for the treatment of pain

Carter, David S.,Alam, Muzaffar,Cai, Haiying,Dillon, Michael P.,Ford, Anthony P.D.W.,Gever, Joel R.,Jahangir, Alam,Lin, Clara,Moore, Amy G.,Wagner, Paul J.,Zhai, Yansheng

scheme or table, p. 1628 - 1631 (2009/11/30)

P2X purinoceptors are ligand-gated ion channels whose endogenous ligand is ATP. Both the P2X3 and P2X2/3 receptor subtypes have been shown to play an important role in the regulation of sensory function and dual P2X3/P2X2/3 antagonists offer significant potential for the treatment of pain. A high-throughput screen of the Roche compound collection resulted in the identification of a novel series of diaminopyrimidines; subsequent optimization resulted in the discovery of RO-4, a potent, selective and drug-like dual P2X3/P2X2/3 antagonist.

Process for synthesis of phenoxy diaminopyrimidine derivatives

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Page/Page column 21; 23-24, (2010/11/26)

A method for preparing a compound of formula I the method comprising treating a compound of formula d with an iodination reagent, to form the compound of formula I, wherein R1, R2 and R3 are as defined herein.

Methods of using diaminopyrimidine P2X3 and P2X2/3 receptor modulators for treatment of respiratory and gastrointestinal diseases

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Page/Page column 87-88, (2010/11/26)

Methods for treating respiratory and gastrointestinal diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein D, X, Y, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein.

Diaminopyrimidines as P2X3 and P2X2/3 modulators

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Page/Page column 31-32, (2008/06/13)

Compounds and methods for treating diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I): wherein D, X, Rs

Diaminopyrimidines as P2X3 and P2X2/3 antagonists

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Page/Page column 95-96, (2010/02/14)

Compounds and methods for treating diseases mediated by a P2X3 and/or a P2X2/3 receptor antagonist, the methods comprising administering to a subject in need thereof an effective amount of a compound of formula (I): or a pharmaceutically acceptable salt, solvate or prodrug thereof, wherein D, X, Y, R1, R2, R3, R4, R5, R6, R7 and R8 are as defined herein.

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