865444-79-7

Basic information

• Product Name: 4-CHLORO-5-METHYL-IMIDAZO[5,1-F][1,2,4]TRIAZINE
• Synonyms: 4-CHLORO-5-METHYL-IMIDAZO[5,1-F][1,2,4]TRIAZINE;4-Chloro-5-methylimidazo[1,5-f][1,2,4]triazine
• CAS NO: 865444-79-7
• Molecular Formula: C₆H₅ClN₄
• Molecular Weight: 168.58
• Mol File: 865444-79-7.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 4-CHLORO-5-METHYL-IMIDAZO[5,1-F][1,2,4]TRIAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-5-METHYL-IMIDAZO[5,1-F][1,2,4]TRIAZINE(865444-79-7)
• EPA Substance Registry System: 4-CHLORO-5-METHYL-IMIDAZO[5,1-F][1,2,4]TRIAZINE(865444-79-7)

Safety Data

• Hazardous Substances Data: 865444-79-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Synthesis:
4-chloro-5-methyl-imidazo[5,1-f][1,2,4]triazine is used as a building block for the synthesis of pharmaceutical drugs. Its unique structure and reactivity allow it to be incorporated into various drug molecules, contributing to the development of new therapeutic agents.
Used in Agrochemical Production:
4-chloro-5-methyl-imidazo[5,1-f][1,2,4]triazine also serves as a building block in the synthesis of agrochemicals. Its ability to form new carbon-nitrogen bonds makes it a valuable component in the creation of pesticides and other agricultural chemicals, enhancing crop protection and yield.
Used as a Reagent in Organic Chemistry:
4-chloro-5-methyl-imidazo[5,1-f][1,2,4]triazine is utilized as a reagent in organic chemistry reactions, particularly in the formation of new carbon-nitrogen bonds. Its versatile reactivity enables it to participate in a wide range of chemical processes, making it an indispensable tool for organic chemists in the synthesis of various compounds.

Upstream product

• 865444-78-6 5-methyl-3H,4H-imidazo[4,3-f][1,2,4]triazin-4-one 

Downstream Products

• 1023758-34-0 N-(4-methoxyphenyl)-N,5-dimethylimidazo[5,1-f][1,2,4]triazin-4-amine 
• 1023758-32-8 N-(3,5-dimethoxyphenyl)-5-methylimidazo[5,1-f][1,2,4]triazin-4-amine 

Relevant articles and documents

N-ARYL-ISOXAZOLOPYRIMIDIN-4-AMINES AND RELATED COMPOUNDS AS ACTIVATORS OF CASPASES AND INDUCERS OF APOPTOSIS AND THE USE THEREOF

Disclosed are N-aryl-isoxazolopyrimidin-4-amines and related compounds thereof, represented by the Formula (I): wherein Ar, R1-R5, A, B, D, E, F and H are defined herein. The present invention relates to the discovery that compounds having Formula I are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention may be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.

Methods for synthesizing imidazotriazinones

Methods of synthesizing imidazotriazinones, such as vardenafil, and compositions useful for the same are disclosed.

A novel method for the synthesis of imidazo[5,1-f][1,2,4]triazin-4(3H)-ones

Imidazo[5,1-f][1,2,4]triazinones, as isosteres of purine, are of interest for pharmaceutical research. The syntheses reported in the literature generally require several steps. We report a novel method to access a broad range of diversely substituted derivatives. The key step is the electrophilic N-amination of 3H-imidazoles containing a 4-carbonyl group. Several different substituted imidazoles have been N-aminated in this manner. The resulting N-aminoimidazoles were cyclized under different conditions to the corresponding imidazotriazinones, which allowed for additional diversification. This novel method was applied in a formal synthesis of vardenafil, a well-known representative of this class of compounds. Furthermore, we report the first synthesis of a 7-aryl-imidazotriazinone via bromination of an unsubstituted imidazotriazinone followed by a Suzuki coupling.