866394-48-1 Usage
Uses
Used in Pharmaceutical Industry:
(7R,8S)-8-(3,4-DiMethoxyphenyl)-8-(2-propen-1-yl)-1,4-dioxaspiro[4.5]decan-7-ol is used as an intermediate in the synthesis of Mesembrine (M338950) for its serotonin-uptake inhibitory properties. This makes it a valuable compound in the development of potential antidepressant and anxiolytic medications, as it can help regulate mood and alleviate symptoms of depression and anxiety.
Used in Research and Development:
As a key intermediate in the synthesis of Mesembrine, (7R,8S)-8-(3,4-DiMethoxyphenyl)-8-(2-propen-1-yl)-1,4-dioxaspiro[4.5]decan-7-ol plays a crucial role in research and development efforts aimed at understanding the mechanisms of action and potential therapeutic applications of Mesembrine. This can lead to the discovery of new drugs and treatments for various mental health disorders.
Check Digit Verification of cas no
The CAS Registry Mumber 866394-48-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,6,6,3,9 and 4 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 866394-48:
(8*8)+(7*6)+(6*6)+(5*3)+(4*9)+(3*4)+(2*4)+(1*8)=221
221 % 10 = 1
So 866394-48-1 is a valid CAS Registry Number.
866394-48-1Relevant articles and documents
Opening of aryl-substituted epoxides to form quaternary stereogenic centers: Synthesis of (-)-mesembrine
Taber, Douglass F.,He, Yigang
, p. 7711 - 7714 (2007/10/03)
Cycloalkanones are easily converted into aryl-substituted cyclic alkenes by the addition of an aryl Grignard reagent followed by dehydration. These alkenes are good substrates for asymmetric epoxidation. We have found that the addition of allylic and benzylic Grignard reagents can occur preferentially at the benzylic position of the derived epoxides to give the quaternary stereogenic center. This approach led to a short synthesis of the nanomolar serotonin re-uptake inhibitor (-)-mesembrine.