866885-53-2

Basic information

• Product Name: 2-Hydroxy-3-nitrophenyl-acetate
• Synonyms: 2-Hydroxy-3-nitrophenyl-acetate;Methyl 2-(2-hydroxy-3-nitrophenyl)acetate;Benzeneaceticacid,2-hydroxy-3-nitro-,methylester
• CAS NO: 866885-53-2
• Molecular Formula: C8H7NO5
• Molecular Weight: 197.14488
• Mol File: 866885-53-2.mol

Chemical Properties

• Melting Point: 115-116 °C
• Boiling Point: 314.0±27.0 °C(Predicted)
• Appearance: /
• Density: 1.384±0.06 g/cm3(Predicted)
• PKA: 6.52±0.10(Predicted)
• CAS DataBase Reference: 2-Hydroxy-3-nitrophenyl-acetate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Hydroxy-3-nitrophenyl-acetate(866885-53-2)
• EPA Substance Registry System: 2-Hydroxy-3-nitrophenyl-acetate(866885-53-2)

Safety Data

• Hazardous Substances Data: 866885-53-2(Hazardous Substances Data)

Upstream product

• 67-56-1 methanol 
• 614-75-5 2-Hydroxyphenylacetic acid 
• 22446-37-3 methyl (2-hydroxyphenyl)acetate 

Relevant articles and documents

NOVEL COMPOUNDS FOR THE TREATMENT OF CANCER AND INFLAMMATORY DISEASES

The present invention relates to novel compounds and pharmaceutical compositions thereof which may be useful in the treatment and/or prevention of various conditions. The present invention also provides methods of preparing such compounds and compositions, and methods of using the same.

Esterification-nitration of ortho-hydroxyphenyl carboxylic acids and benzole acids with cerium(IV) ammonium nitrate (CAN)

A convenient and useful esterification was realized, and this reaction proceeded without a dehydrating reagent or water removal equipment. A series of ortho -hydroxyphenyl carboxylic acids and benzoic acids were transformed to their corresponding methyl esters under CAN/CH3OH reaction conditions. Whereas in an aprotic solvent, acetonitrile, sp3-C tethered ortho-hydroxyphenyl carboxylic acids undergo simultaneous o,p-dinitration and intramolecular esterification reactions in good yields. Also, 2-((1E)-2-nitrovinyl)-4-nitro-phenol (3e) showed selective cytotoxicities to ward MCF-7, HEP G2, and HEP 3B cell lines with IQovalues of 23.50, 7.33, and7.59ug/mL,respectively.