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4-Bromo-2-chloro-5-methylpyridine is a halogenated heterocyclic compound with a pyridine ring structure, featuring a bromine atom at the 4-position, a chlorine atom at the 2-position, and a methyl group at the 5-position. This unique molecular arrangement endows it with specific chemical properties that make it a valuable intermediate in organic synthesis and medicinal chemistry.

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  • 867279-13-8 Structure
  • Basic information

    1. Product Name: 4-BroMo-2-chloro-5-Methylpyridine
    2. Synonyms: 4-BroMo-2-chloro-5-Methylpyridine
    3. CAS NO:867279-13-8
    4. Molecular Formula: C6H5BrClN
    5. Molecular Weight: 206.4676
    6. EINECS: N/A
    7. Product Categories: Heterocycle-Pyridine series
    8. Mol File: 867279-13-8.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 252.3±35.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.624±0.06 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
    8. Solubility: N/A
    9. PKA: 0?+-.0.10(Predicted)
    10. CAS DataBase Reference: 4-BroMo-2-chloro-5-Methylpyridine(CAS DataBase Reference)
    11. NIST Chemistry Reference: 4-BroMo-2-chloro-5-Methylpyridine(867279-13-8)
    12. EPA Substance Registry System: 4-BroMo-2-chloro-5-Methylpyridine(867279-13-8)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 867279-13-8(Hazardous Substances Data)

867279-13-8 Usage

Uses

Used in Pharmaceutical Industry:
4-Bromo-2-chloro-5-methylpyridine is used as a key intermediate in the synthesis of heterocyclic amide derivatives, which are known for their potential as anticancer agents. These heterocyclic amide derivatives target various cellular pathways and mechanisms involved in cancer progression, making them promising candidates for the development of novel therapeutics against various types of cancer.
In the preparation of heterocyclic amide derivatives, 4-Bromo-2-chloro-5-methylpyridine serves as a building block that can be further functionalized and modified to create a diverse range of bioactive molecules with improved pharmacological properties. Its presence in the molecular structure can influence the binding affinity, selectivity, and overall effectiveness of the resulting compounds, contributing to the advancement of cancer treatment options.

Check Digit Verification of cas no

The CAS Registry Mumber 867279-13-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 8,6,7,2,7 and 9 respectively; the second part has 2 digits, 1 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 867279-13:
(8*8)+(7*6)+(6*7)+(5*2)+(4*7)+(3*9)+(2*1)+(1*3)=218
218 % 10 = 8
So 867279-13-8 is a valid CAS Registry Number.

867279-13-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 15, 2017

Revision Date: Aug 15, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-Bromo-2-chloro-5-methylpyridine

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:867279-13-8 SDS

867279-13-8Relevant articles and documents

PRMT5 INHIBITORS

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Page/Page column 43; 47; 48, (2019/05/30)

The present invention provides a compound of Formula (I) or the pharmaceutically acceptable salts thereof, which are PRMT5 inhibitors.

PYRIDINE INHIBITORS OF ERK2 AND USES THEREOF

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Page/Page column 24; 39-40, (2008/06/13)

The present invention relates to compounds useful of inhibitors of protein kinases of formula (I). The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of var

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