867380-38-9

Basic information

• Product Name: 5-bromo-2-p-tolylpyridine
• Synonyms: 5-bromo-2-p-tolylpyridine
• CAS NO: 867380-38-9
• Molecular Formula: C12H10BrN
• Molecular Weight: 248.1185
• Mol File: 867380-38-9.mol

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 5-bromo-2-p-tolylpyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-bromo-2-p-tolylpyridine(867380-38-9)
• EPA Substance Registry System: 5-bromo-2-p-tolylpyridine(867380-38-9)

Safety Data

• Hazardous Substances Data: 867380-38-9(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
5-bromo-2-p-tolylpyridine is used as a building block for the synthesis of various pharmaceuticals. Its reactivity allows it to participate in coupling, substitution, and cross-coupling reactions, enabling the creation of complex organic compounds with potential therapeutic applications.
Used in Agrochemical Industry:
In the agrochemical industry, 5-bromo-2-p-tolylpyridine is utilized as a key intermediate in the synthesis of pesticides and other agrochemical products. Its versatility in chemical reactions facilitates the development of new and effective compounds for agricultural use.
Used in Organic Material Synthesis:
5-bromo-2-p-tolylpyridine is also employed in the synthesis of various organic materials. Its ability to engage in different types of chemical reactions makes it a valuable component in the development of new materials with specific properties for diverse applications.

Upstream product

• 624-28-2 2,5-dibromopyridine 
• 15106-88-4 di(p-tolyl)zinc 
• 5720-05-8 4-methylphenylboronic acid 
• 5142-75-6 tri(p-tolyl)bismuth 
• 626-55-1 3-Bromopyridine 
• 106-38-7 para-bromotoluene 

Relevant articles and documents

Synthesis and properties of electrophosphorescent chelating polymers with iridium complexes in the conjugated backbone

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One-step highly selective borylation/Suzuki cross-coupling of two distinct aryl bromides in pure water

A Na2PdCl4-catalysed B2(OH)4-mediated direct cross-coupling of two distinct aryl bromides in pure water is described. This one-step borylation/Suzuki method exhibits an outstanding cross-coupling selectivity and no tendency to produce homocoupling products, therefore leading to biaryls and heterobiaryls in moderate to good yields. Moreover, the reaction has high regio-selectivity and can be scaled-up. Using such a simple, economical and practical protocol, the unsymmetrical diarylation of 3,5-dibromopryidine is achieved.

Triarylbismuthanes as threefold aryl-transfer reagents in regioselective cross-coupling reactions with bromopyridines and quinolines

Cross-coupling studies using bromopyridines and bromoquinolines with triarylbismuths as threefold coupling reagents in substoichiometric amounts under Pd-catalysed conditions are disclosed. The reactivity was high with both mono- and dibromopyridyl substrates, and mono- and bis-couplings were carried out regioselectively. A library of monoaryl and diaryl pyridines was formed in high yields. A one-pot strategy provided a simple and straightforward synthesis of both symmetrical and unsymmetrical diarylpyridines. Arylations of 2-bromo- and 3-bromoquinolines were achieved with triarylbismuth reagents. This study demonstrates that triarylbismuths may be used as threefold arylating reagents for the synthesis of aryl pyridines and quinolines through couplings with bromopyridines and bromoquinolines under Pd-catalysed conditions. Copyright

Palladium-catalyzed highly regioselective 2-arylation of 2,x-dibromopyridines and its application in the efficient synthesis of a 17β-HSD1 inhibitor

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