868944-69-8

Basic information

• Product Name: 2-(2-fluorophenyl)nicotinonitrile
• Synonyms: 2-(2-fluorophenyl)nicotinonitrile
• CAS NO: 868944-69-8
• Molecular Formula: C₁₂H₇FN₂
• Molecular Weight: 198
• Mol File: 868944-69-8.mol

Chemical Properties

• Melting Point: 74-76 °C(Solv: heptane (142-82-5); ethyl acetate (141-78-6))
• Boiling Point: 342.3±32.0 °C(Predicted)
• Appearance: /
• Density: 1.25±0.1 g/cm3(Predicted)
• PKA: 0.39±0.22(Predicted)
• CAS DataBase Reference: 2-(2-fluorophenyl)nicotinonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-fluorophenyl)nicotinonitrile(868944-69-8)
• EPA Substance Registry System: 2-(2-fluorophenyl)nicotinonitrile(868944-69-8)

Safety Data

• Hazardous Substances Data: 868944-69-8(Hazardous Substances Data)

Upstream product

• 6602-54-6 2-chloro-3-pyridinecarbonitrile 
• 346656-39-1 2-(2-fluorophenyl)-5,5-dimethyl-[1,3,2]dioxaborinane 
• 1993-03-9 o-fluorophenylboronic acid 

Downstream Products

• 1213704-84-7 2-(2-fluorophenyl)-4-iodonicotinonitrile 
• 1213704-91-6 2-(2-chloro-6-fluorophenyl)nicotinonitrile 
• 1213704-92-7 2-(2-bromo-6-fluorophenyl)nicotinonitrile 
• 1213704-94-9 5-bromo-2-(2-fluorophenyl)nicotinonitrile 
• 1169826-23-6 2-(2-fluoro-6-methoxyphenyl)nicotinonitrile 
• 1213704-81-4 6-butyl-2-(2-fluorophenyl)nicotinonitrile 
• 1213704-86-9 2-(2-fluorophenyl)-4-trimethylsilanylnicotinonitrile 
• 1213704-87-0 2-(2-fluorophenyl)-4-(methylsulfanyl)nicotinonitrile 
• 1213704-93-8 2-(3-cyanopyridin-2-yl)-3-fluorophenyl acetate 
• 34016-27-8 5-methylbenzo[h]-1,6-naphthyridine 
• 1213704-80-3 2-(2-fluorophenyl)-6-methylnicotinonitrile 
• 1213704-82-5 6-tert-butyl-2-(2-fluorophenyl)nicotinonitrile 
• 1213704-85-8 4-benzoyl-2-(2-fluorophenyl)nicotinonitrile 
• 1213704-83-6 2-(2-fluorophenyl)-6-phenylnicotinonitrile 

Relevant articles and documents

A new, direct, and efficient synthesis of benzonaphthyridin-5-ones

Microwave-assisted Suzuki cross-coupling reaction of 2-fluorophenylboronic acid with all orthochlorocyanopyridine isomers allowed the rapid syntheses of key intermediates for anionic ring closure, which was performed using potassium hydroxide under microwave irradiation to give benzonaphthyridin-5-ones in high yields.

Synthesis of azaphenanthridines via anionic ring closure

A new and convergent synthesis of azaphenanthridines via an anionic ring closure is reported. Ortho-lithiation/in situ borylation of cyanopyridines produces the corresponding cyanopyridylboronic esters, which undergo a Suzuki-Miyaura cross-coupling to giv

AMINO-TETRAZOLES ANALOGUES AND METHODS OF USE

A compound having Formula (I) or Formula (II) is disclosed as an P2X7 antagonist, wherein A, B, C, Y, Y, Z, m, v, R1, R2, R3, R4, and R 5, are as defined in the description. Methods and compositions for treating disease or condition modulated by P2X7 are also disclosed.