869476-25-5Relevant articles and documents
Galacto configured N-aminoaziridines: A new type of irreversible inhibitor of β-galactosidases
Alcaide, Anna,Trapero, Ana,Pérez, Yolanda,Llebaria, Amadeu
supporting information, p. 5690 - 5697 (2015/05/27)
A new type of galactose mimetics has been synthesized following a straightforward synthetic approach based on cyclohexene olefin aziridination reactions directed by hydroxyl substituents. These enantiomerically pure galacto-configured N-aminoaziridines are potent irreversible inhibitors of Aspergillus oryzae and Escherichia coli β-galactosidases.
Convenient strategy for the synthesis of highly functionalizable hydroxylated unsaturated azepanes
Goumain, Sophie,Taghzouti, Hanaa,Portella, Charles,Behr, Jean-Bernard,Plantier-Royon, Richard
scheme or table, p. 4440 - 4443 (2012/09/25)
A convenient approach to the construction of dihydroxylated unsaturated azepanes featuring a functional group (ethoxycarbonyl)methyl or (cyano)methyl at C-2 was achieved from a pent-4-enal synthon obtained in four steps from d-xylose. The key step of the sequence relied on the conjugate addition of allylamine to α,β-unsaturated ester or nitrile, prepared by Wadsworth-Emmons olefination. Subsequent RCM afforded the target unsaturated azepanes.
A short synthesis of (+)-cyclophellitol
Hansen, Flemming Gundorph,Bundgaard, Eva,Madsen, Robert
, p. 10139 - 10142 (2007/10/03)
A new synthesis of (+)-cyclophellitol, a potent β-glucosidase inhibitor, has been completed in nine steps from D-xylose. The key transformations involve a zinc-mediated fragmentation of benzyl-protected methyl 5-deoxy-5-iodo-xylofuranoside followed by a h