871014-28-7Relevant articles and documents
Indoleamine-2,3-dioxygenase inhibitor as well as preparation method and application thereof
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, (2019/08/12)
The invention provides a compound as shown in a formula (I). The invention also relates to a pharmaceutical composition containing the compound of the formula (I) and application of the compound to preparation of an indoleamine-2,3-dioxygenase (IDO) inhibitor drug. The compound prepared by the method of the invention has an obvious inhibiting effect on IDO protease and is stable in metabolism in vivo. The compound or a pharmaceutical composition thereof provided by the invention can be used for preparing the IDO inhibitor drug, and can also be used for preparing medicines for preventing and/ortreating diseases with pathological characteristics of an IDO-mediated tryptophan metabolic pathway.
2,4-DIAMINOPYRIMIDINE COMPOUND
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Page/Page column 28, (2011/06/24)
[Problem] Provided is a compound which is useful as an active ingredient for a pharmaceutical having a PKCθ inhibition activity, particularly a pharmaceutical composition for inhibiting acute rejection occurring in transplantation. [Means for Solution] Th
Process for preparation of intermediates of carbocyclic nucleoside analogs
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, (2008/06/13)
A compound of the formula: STR1 wherein A is a purin-9-yl group, a heterocyclic isostere of a purin-9-yl group, a pyrimidin-1-yl group or a heterocyclic isostere of a pyrimidin-1-yl group; E is hydrogen, --CH2 OH or --OH; and G and D are indepe