871502-87-3

Basic information

• Product Name: 4-BROMO-2-FORMYLBENZOIC ACID
• Synonyms: 4-BROMO-2-FORMYLBENZOIC ACID
• CAS NO: 871502-87-3
• Molecular Formula: C₈H₅BrO₃
• Molecular Weight: 229.0275
• EINECS: -0
• Mol File: 871502-87-3.mol

Chemical Properties

• Boiling Point: 360.6±32.0 °C(Predicted)
• Appearance: /
• Density: 1.764±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 4.34±0.10(Predicted)
• CAS DataBase Reference: 4-BROMO-2-FORMYLBENZOIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMO-2-FORMYLBENZOIC ACID(871502-87-3)
• EPA Substance Registry System: 4-BROMO-2-FORMYLBENZOIC ACID(871502-87-3)

Safety Data

• Hazardous Substances Data: 871502-87-3(Hazardous Substances Data)

Usage

Uses

Used in Organic Synthesis:
4-BROMO-2-FORMYLBENZOIC ACID is used as a building block for the synthesis of various derivatives and analogs, playing a crucial role in the development of new organic compounds.
Used in Pharmaceutical Research:
In the pharmaceutical industry, 4-BROMO-2-FORMYLBENZOIC ACID is utilized as an intermediate for the production of dyes, pigments, and other organic compounds, contributing to the advancement of drug development.
Used in Drug Development:
As a formylbenzoic acid derivative, 4-BROMO-2-FORMYLBENZOIC ACID is used in the development of new drugs and chemotherapeutic agents, leveraging its structural and functional properties to enhance therapeutic outcomes.
Used in Material and Chemical Process Research and Development:
4-BROMO-2-FORMYLBENZOIC ACID is employed as an important chemical in the research and development of new materials and chemical processes, driving innovation in various scientific fields.

Upstream product

• 119-67-5 o-carboxybenzaldehyde 
• 102126-70-5 5-bromo-3-bromo-3H-isobenzofuran-1-one 
• 670256-21-0 4-bromo-2-(hydroxymethyl)benzoic acid 
• 6941-75-9 5-Bromoisoindoline-1,3-dione 
• 65399-05-5 5-amino-3H-isobenzofuran-1-one 
• 64169-34-2 5-bromophthalide 

Downstream Products

• 871502-90-8 4-bromo-2-bis(5-methyl-2-furyl)methylbenzoic acid 
• 412299-71-9 5-methyl-3-phenylisobenzofuran-1(3H)-one 
• 1260795-42-3 methyl 4-bromo-2-formylbenzoate 

Relevant articles and documents

Design, synthesis, and structure–activity relationship study of potent mapk11 inhibitors

Huntington’s disease (HD) is a rare single-gene neurodegenerative disease, which can only be treated symptomatically. Currently, there are no approved drugs for HD on the market. Studies have found that MAPK11 can serve as a potential therapeutic target f

Synthesis of 3-Benzylphthalide Derivatives by Using a TDAE Strategy

A one-pot synthesis of new 3-benzylphthalide derivatives was developed by using a strategy based on tetrakis(dimethylamino)ethylene (TDAE). The reactions in the presence of TDAE of substituted benzyl chlorides with methyl 2-formylbenzoate or of substitute

Indium-Catalyzed C?F Bond Transformation through Oxymetalation/β-Fluorine Elimination to Access Fluorinated Isocoumarins

Fluorinated heterocycles have attracted much attention in the pharmaceutical and agrochemical industries. Many strategies have already been developed to achieve the synthesis of fluorinated heterocycles. Formidable challenges remain, however, in the synthesis of fluorinated isocoumarin derivatives that are among the most alluring structural motifs. Herein, the indium-catalyzed C?F bond transformation of 2-(2,2-difluorovinyl) benzoates is reported, which are readily accessible compounds, to give a diverse array of fluorinated isocoumarins. The present reaction proceeds smoothly using inexpensive reagents: a catalytic amount of indium salt in the presence of zinc salt. A theoretical calculation of potential energy profiles showed that the reaction consists of oxymetalation with the elimination of alkyl halide and the β-fluorine elimination.

Engineering a highly selective probe for ratiometric imaging of H2S: N and revealing its signaling pathway in fatty liver disease

Hydrogen polysulfides (H2Sn, n > 1) have continuously been proved to act as important signal mediators in many physiological processes. However, the physiological role of H2Sn and their signaling pathways in complex diseases, such as the most common liver

Efficient Heterogeneous CO2 to CO Conversion with a Phosphonic Acid Fabricated Cofacial Iron Porphyrin Dimer

For developing renewable fuels and controlling global warming, catalyst promoted conversion of CO2 to CO is essential. Numerous CO2 to CO conversion molecular catalysts have shown very high activity and stability. For large-scale con

Bioorthogonal double-fluorogenic siliconrhodamine probes for intracellular super-resolution microscopy

A series of double-fluorogenic siliconrhodamine probes were synthesized. These tetrazine-functionalized, membrane-permeable labels allowed site-specific bioorthogonal tagging of genetically manipulated intracellular proteins and subsequent imaging using s

Isomerically Pure Tetramethylrhodamine Voltage Reporters

We present the design, synthesis, and application of a new family of fluorescent voltage indicators based on isomerically pure tetramethylrhodamines. These new Rhodamine Voltage Reporters, or RhoVRs, use photoinduced electron transfer (PeT) as a trigger for voltage sensing, display excitation and emission profiles in the green to orange region of the visible spectrum, demonstrate high sensitivity to membrane potential changes (up to 47% ΔF/F per 100 mV), and employ a tertiary amide derived from sarcosine, which aids in membrane localization and simultaneously simplifies the synthetic route to the voltage sensors. The most sensitive of the RhoVR dyes, RhoVR 1, features a methoxy-substituted diethylaniline donor and phenylenevinylene molecular wire at the 5′-position of the rhodamine aryl ring, exhibits the highest voltage sensitivity to date for red-shifted PeT-based voltage sensors, and is compatible with simultaneous imaging alongside green fluorescent protein-based indicators. The discoveries that sarcosine-based tertiary amides in the context of molecular-wire voltage indicators prevent dye internalization and 5′-substituted voltage indicators exhibit improved voltage sensitivity should be broadly applicable to other types of PeT-based voltage-sensitive fluorophores.

Facile construction of pyrrolo[1,2-: B] isoquinolin-10(5 H)-ones via a redox-amination-aromatization-Friedel-Crafts acylation cascade reaction and discovery of novel topoisomerase inhibitors

An efficient redox-amination-aromatization-Friedel-Crafts acylation cascade process from trans-4-hydroxyproline and 2-formylbenzoic acids has been developed for the synthesis of pyrrolo[1,2-b]isoquinolin-10(5H)-ones. Compound 3h was identified as a new potent dual topoisomerase I/II inhibitor.

Asymmetric Organocatalytic Synthesis of 4-Aminoisochromanones via a Direct One-Pot Intramolecular Mannich Reaction

A highly stereoselective one-pot intramolecular Mannich reaction using 2-oxopropyl-2-formylbenzoates and anilines as substrates, catalyzed by a secondary amine, has been developed. The procedure leads to a new class of 4-aminoisochromanones bearing two ad

An Efficient Entry to syn- and anti-Selective Isoindolinones via an Organocatalytic Direct Mannich/Lactamization Sequence

(Chemical Equation Presented) An organocatalytic direct Mannich-lactamization sequence for the syntheses of pharmacologically important enantioenriched isoindolinones is reported. The method utilizes simple α-amino acids to deliver syn- and anti- selectiv