1221485-83-1

Basic information

• Product Name: Skepinone-L
• Synonyms: 5H-Dibenzo[a,d]cyclohepten-5-one, 2-[(2,4-difluorophenyl)amino]-7-[(2R)-2,3-dihydroxypropoxy]-10,11-dihydro-;Skepinone-L, >=98%;3-(2,4-difluoroanilino)-9-[(2R)-2,3-dihydroxypropoxy]-5,6-dihydrodibenzo[3,1-[7]annulen-11-one;(R)-2-((2,4-Difluorophenyl)amino)-7-(2,3-dihydroxypropoxy)-10,11-dihydro-5H-dibenzo[a,d][7]ann;Skepinone-L;2-[(2,4-Difluorophenyl)amino]-7-[(2R)-2,3-dihydroxypropoxy]-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5-one
• CAS NO: 1221485-83-1
• Molecular Formula: C₂₄H₂₁F₂NO₄
• Molecular Weight: 425.4246464
• Product Categories: Inhibitors;MAPK
• Mol File: 1221485-83-1.mol

Chemical Properties

• Boiling Point: 629.0±55.0 °C(Predicted)
• Appearance: /
• Density: 1.384±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C(protect from light)
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 13.49±0.20(Predicted)
• CAS DataBase Reference: Skepinone-L(CAS DataBase Reference)
• NIST Chemistry Reference: Skepinone-L(1221485-83-1)
• EPA Substance Registry System: Skepinone-L(1221485-83-1)

Safety Data

• Hazardous Substances Data: 1221485-83-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Skepinone-L is used as a potent and highly selective inhibitor of p38 MAP kinase for its ability to impair platelet activation and thrombus formation, making it a valuable tool in the development of therapeutics targeting inflammatory and cardiovascular diseases.
Used in Research Applications:
Skepinone-L is used as a research tool for studying the role of p38 MAP kinase in various cellular processes, including the inhibition of heat shock protein 27 (HSP27) phosphorylation and the prevention of cytosolic phospholipase A2 phosphorylation in platelets, which helps in understanding the mechanisms of platelet secretion and aggregation.

references

[1]. koeberle, s c et al., skepinone-l is a selective p38 mitogen-activated protein kinase inhibitor. nature chemical biology, 2012, 8(2), 141-143.

Upstream product

• 871502-87-3 4-bromo-2-formylbenzoic acid 
• 1221485-69-3 2-((2,4-difluorophenyl)amino)-7-methoxy-10,11-dihydro-5H-dibenzo[a,d][7]annulen-5-one 
• 1353948-60-3 2-(2,4-difluorophenylamino)-7-(S-1,2-isopropylidenglycer-3-yl)-10,11-dihydro-dibenzo-[a,d]-cyclohepten-5-one 

Relevant articles and documents

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