874279-33-1Relevant articles and documents
Nickel-Catalyzed Ligand-Free Hiyama Coupling of Aryl Bromides and Vinyltrimethoxysilane
Wei, Shichao,Mao, Yongjun,Shi, Shi-Liang
supporting information, p. 1670 - 1674 (2021/02/26)
We herein disclose the first Ni-catalyzed Hiyama coupling of aryl halides with vinylsilanes. This protocol uses cheap, nontoxic, and stable vinyltrimethoxysilane as the vinyl donor, proceeds under mild and ligand-free conditions, furnishing a diverse variety of styrene derivatives in high yields with excellent functional group compatibility.
Superacid-promoted additions involving vinyl-substituted pyrimidines, quinoxalines, and quinazolines: Mechanisms correlated to charge distributions
Zhang, Yiliang,Sheets, Matthew R.,Raja, Erum K.,Boblak, Kenneth N.,Klumpp, Douglas A.
supporting information; experimental part, p. 8467 - 8469 (2011/07/29)
The superacid-promoted reactions of vinyl-substituted N-heterocycles have been studied. Diprotonated pyrimidines, quinoxalines, and quinazolines exhibit an unusual regioelectronic effect that controls the type of addition reaction observed. Depending on the ring position of the vinyl substituent, either conjugate addition or Markovnikov addition occurs. The mode of addition has been shown to correlate well to NBO calculated charges.
Identification of 2-(4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-3-yl)-ethylamine derivatives as novel GnRH receptor antagonists
Chen, Mi,Guo, Zhiqiang,Lanier, Marion C.,Zhao, Liren,Betz, Stephen F.,Huang, Charles Q.,Loweth, Colin J.,Ashweek, Neil J.,Liu, Xin-Jun,Struthers, R. Scott,Bradbury, Margaret J.,Behan, James W.,Wen, Jenny,O'Brien, Zhihong,Saunders, John,Zhu, Yun-Fei
, p. 3845 - 3850 (2008/02/13)
A novel series of 2-(4,5,6,7-tetrahydro-1H-pyrrolo[3,2-c]pyridin-3-yl)-ethylamine derivatives were designed and synthesized as GnRH receptor antagonists. SAR studies led to a series of highly active molecules against both the rat and human receptors. Furt
Piperazinylimidazopyridine and piperazinyltriazolopyridine antagonists of gonadotropin releasing hormone receptor
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Page/Page column 37, (2008/06/13)
The present invention relates to Gonadotropin Releasing Hormone (GnRH, also known as Luteinizing Hormone Releasing Hormone) receptor antagonists.