130345-50-5

Basic information

• Product Name: QUINOXALINE-6-CARBALDEHYDE
• Synonyms: 6-QUINOXALINECARBOXALDEHYDE;AKOS BBS-00005346;IFLAB-BB F0178-0077;RARECHEM AM LA 0024;QUINOXALINE-6-CARBALDEHYDE;QUINOXALINE-6-CARBOXALDEHYDE;6-Quinoxalinecarboxaldehyde (9CI);6-quinoxaline forMaldehyde
• CAS NO: 130345-50-5
• Molecular Formula: C₉H₆N₂O
• Molecular Weight: 158.16
• Product Categories: ALDEHYDE;Building Blocks;Quinoxaline
• Mol File: 130345-50-5.mol
• Article Data: 16

Chemical Properties

• Melting Point: 130-131 °C
• Boiling Point: 319.783 °C at 760 mmHg
• Flash Point: 151.632 °C
• Appearance: /
• Density: 1.3 g/cm³
• Vapor Pressure: 0.000331mmHg at 25°C
• Refractive Index: 1.7
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -0.24±0.30(Predicted)
• CAS DataBase Reference: QUINOXALINE-6-CARBALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: QUINOXALINE-6-CARBALDEHYDE(130345-50-5)
• EPA Substance Registry System: QUINOXALINE-6-CARBALDEHYDE(130345-50-5)

Safety Data

• Hazard Codes: Xi
• Statements: 41
• Safety Statements: 26-39
• HazardClass: IRRITANT
• Hazardous Substances Data: 130345-50-5(Hazardous Substances Data)

Usage

General Description

Quinoxaline-6-carbaldehyde is a chemical compound with the molecular formula C9H6N2O. It is a yellow crystalline substance with a faint odor. QUINOXALINE-6-CARBALDEHYDE is commonly used in the pharmaceutical industry as an intermediate for the synthesis of various biologically active compounds. It has also been studied for its potential use as an optical sensor for the detection of metal ions due to its fluorescence properties. Additionally, quinoxaline-6-carbaldehyde has been reported to possess antibacterial and antifungal activities, making it a potential candidate for the development of new antimicrobial agents. However, further research is needed to fully understand and exploit the properties and potential applications of this compound.

InChI:InChI=1/C9H6N2O/c12-6-7-1-2-8-9(5-7)11-4-3-10-8/h1-6H

Upstream product

• 50998-17-9 6-bromoquinoxaline 
• 201230-82-2 carbon monoxide 
• 258503-93-4 quinoxaline-6-carbonyl chloride 
• 874279-33-1 6-vinylquinoxaline 
• 131543-46-9 Glyoxal 
• 496-72-0 4-methyl-1,2-diaminobenzene 
• 1313-13-9 manganese dioxide 
• 488834-75-9 6-hydroxymethyl-quinoxaline 
• 6344-72-5 6-methylquinoxaline 
• 619-05-6 3,4-diaminobenzoic acid 
• 6925-00-4 quinoxaline-6-carboxylic acid 
• 875558-38-6 N-methoxy-N-methylquinoxaline-6-carboxamide 

Downstream Products

• 1025821-33-3 (5Z)-2-[(2,6-Dichlorophenyl)amino]-5-(6-quinoxalinylmethylidene)-1,3-thiazol-4(5H)-one 
• 53967-21-8 6-bromomethyl-quinoxaline 
• 1428968-21-1 1-(1H-indol-3-yl)-2-((3-methoxyphenyl)amino)-2-(quinoxalin-6-yl)ethanone 
• 916052-96-5 N-(2-chloro-3-{[(5Z)-4-oxo-5-(6-quinoxalinylmethylidene)-4,5-dihydro-1,3-thiazol-2-yl]amino}phenyl)cyclobutanecarboxamide 
• 916053-11-7 N-(2-chloro-3-{[(5Z)-4-oxo-5-(6-quinoxalinylmethylidene)-4,5-dihydro-1,3-thiazol-2-yl]amino}phenyl)benzamide 
• 916052-94-3 N-(2-chloro-3-{[(5Z)-4-oxo-5-(6-quinoxalinylmethylidene)-4,5-dihydro-1,3-thiazol-2-yl]amino}phenyl)cyclopropanecarboxamide 
• 916052-87-4 N-(2-chloro-3-{[(5Z)-4-oxo-5-(6-quinoxalinylmethylidene)-4,5-dihydro-1,3-thiazol-2-yl]amino}phenyl)-2-methylpropanamide 
• 916053-09-3 N-(2-chloro-3-{[(5Z)-4-oxo-5-(6-quinoxalinylmethylidene)-4,5-dihydro-1,3-thiazol-2-yl]amino}phenyl)methanesulfonamide 
• 1428972-25-1 3-methoxy-N-(quinoxalin-6-ylmethylene)aniline 
• 1427631-49-9 1-(4-fluoro-3-(quinoxaline-6-carbonyl)phenyl)-3-(3-fluorophenyl)urea 
• 1427632-71-0 3-fluoro-N-(4-fluoro-3-(quinoxaline-6-carbonyl)phenyl)benzamide 
• 1428663-52-8 N-(2,4-difluoro-3-(hydroxy(quinoxalin-6-yl)methyl)phenyl)pivalamide 
• 1427633-10-0 N-(2,4-difluoro-3-(quinoxaline-6-carbonyl)phenyl)-3-fluorobenzamide 
• 1427632-42-5 1-(2,4-difluoro-3-(quinoxaline-6-carbonyl)phenyl)-3-(3-fluorophenyl)urea 

Relevant articles and documents

Meta C-H Arylation of Electron-Rich Arenes: Reversing the Conventional Site Selectivity

Controlling site selectivity of C-H activation without using a directing group remains a significant challenge. While Pd(II) catalysts modulated by a mutually repulsive pyridine-type ligand have been shown to favor the relatively electron-rich carbon centers of arenes, reversing the selectivity to favor palladation at the relatively electron-deficient positions has not been possible. Herein we report the first catalytic system that effectively performs meta C-H arylation of a variety of alkoxy aromatics including 2,3-dihydrobenzofuran and chromane with exclusive meta site selectivity, thus reversing the conventional site selectivity governed by native electronic effects. The identification of an effective ligand and modified norbornene (NBE-CO2Me), as well as taking advantage of the statistics, are essential for achieving the exclusive meta selectivity.

CERTAIN CHEMICAL ENTITES, COMPOSITIONS, AND METHODS

Chemical entities that are kinase inhibitors, pharmaceutical compositions and methods of treatment of cancer are described.

AROYLQUINOLINE COMPOUNDS

A serious of nitro heterocyclic derivatives including a structure of formula (I) are provided. In formula (I), P, Q and R1 to R8 are defined in the specification. The derivatives disclosed in the present invention are characterized in inhibiting tubulin p