876500-72-0

Basic information

• Product Name: 6-TRIFLUOROMETHOXYBENZOTHIAZOLE
• Synonyms: 6-TRIFLUOROMETHOXYBENZOTHIAZOLE;6-(Trifluoromethoxy)benzo[d]thiazole
• CAS NO: 876500-72-0
• Molecular Formula: C₈H₄F₃NOS
• Molecular Weight: 219.18
• Mol File: 876500-72-0.mol

Chemical Properties

• Boiling Point: 228.8±35.0 °C(Predicted)
• Appearance: /
• Density: 1.494±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: -0.13±0.10(Predicted)
• CAS DataBase Reference: 6-TRIFLUOROMETHOXYBENZOTHIAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-TRIFLUOROMETHOXYBENZOTHIAZOLE(876500-72-0)
• EPA Substance Registry System: 6-TRIFLUOROMETHOXYBENZOTHIAZOLE(876500-72-0)

Safety Data

• Hazardous Substances Data: 876500-72-0(Hazardous Substances Data)

Usage

Uses

Used in Materials Science:
6-Trifluoromethoxybenzothiazole is utilized as a building block in the synthesis of organic electronic materials. Its unique structure allows it to contribute to the development of advanced materials with improved electronic properties, such as enhanced charge transport and stability.
Used in Biochemical and Medical Research:
As a fluorescent probe, 6-trifluoromethoxybenzothiazole is employed in various biochemical and medical research applications. Its fluorescent properties enable researchers to track and visualize specific biological processes, monitor molecular interactions, and study the behavior of biological systems with greater precision.
Used in Pharmaceutical Development:
6-Trifluoromethoxybenzothiazole may have potential utility in the development of pharmaceuticals. Its intriguing chemical structure and potential biological activity make it a promising candidate for the design of new drugs. Further research is needed to explore its therapeutic potential and optimize its properties for specific medical applications.

Upstream product

• 124-38-9 carbon dioxide 
• 1744-22-5 Riluzole 

Downstream Products

• 1744-22-5 Riluzole 

Relevant articles and documents

Photoelectrochemical cross-dehydrogenative coupling of benzothiazoles with strong aliphatic C-H bonds

A photoelectrochemical strategy for the cross-dehydrogenative coupling of unactivated aliphatic hydrogen donors (e.g.alkanes) with benzothiazoles is reported. We used tetrabutylammonium decatungstate as the photocatalyst to activate strong C(sp3)-H bonds in the chosen substrates, while electrochemistry scavenged the extra electrons.

Iron-catalyzed tandem oxidative coupling and acetal hydrolysis reaction to prepare formylated benzothiazoles and isoquinolines

The aldehyde group is one of the most versatile intermediates in synthetic chemistry, and the introduction of an aldehyde group into heteroarenes is important for the transformation of molecular structure. Herein, we achieved the direct formylation of benzothiazo/les and isoquinolines. The reaction features a novel iron-catalyzed Minisci-type oxidative coupling process using commercially available 1,3-dioxolane as a formylated reagent followed by acetal hydrolysis without a separation process. The reaction can be performed under exceedingly mild reaction conditions and exhibits broad functional group tolerance.

Synthesis of benzothiazoles from 2-aminobenzenethiols in the presence of a reusable polythiazolium precatalyst under atmospheric pressure of carbon dioxide

Synthesis of benzothiazoles from 2-aminobenzenethiols and carbon dioxide was carried out using poly(3,4-dimethyl-5-vinylthiazolium) iodide as a precatalyst to in situ generation of NHCs by deprotonation. The reaction was successfully carried out under mild conditions (1 atm of CO2 and 60–70 °C) with a broad substrate scope and functional group tolerance. The precatalyst salt was recovered and reused for several times without any loss of activity.