876918-40-0

Basic information

• Product Name: Benzonitrile, 5-bromo-3-fluoro-2-hydroxy-
• Synonyms: Benzonitrile, 5-bromo-3-fluoro-2-hydroxy-;5-Bromo-3-fluoro-2-hydroxybenzonitrile
• CAS NO: 876918-40-0
• Molecular Formula: C₇H₃BrFNO
• Molecular Weight: 216
• Mol File: 876918-40-0.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Benzonitrile, 5-bromo-3-fluoro-2-hydroxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzonitrile, 5-bromo-3-fluoro-2-hydroxy-(876918-40-0)
• EPA Substance Registry System: Benzonitrile, 5-bromo-3-fluoro-2-hydroxy-(876918-40-0)

Safety Data

• Hazardous Substances Data: 876918-40-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Benzonitrile, 5-bromo-3-fluoro-2-hydroxyis used as an intermediate in the synthesis of pharmaceuticals for its ability to be incorporated into various drug molecules. Its unique functional groups allow for the formation of diverse chemical bonds, making it a valuable building block in the development of new medications.
Used in Agrochemical Industry:
In the agrochemical industry, Benzonitrile, 5-bromo-3-fluoro-2-hydroxyis utilized as an intermediate in the production of agrochemicals. Its structural features enable it to be a key component in the synthesis of pesticides, herbicides, and other agricultural chemicals, contributing to the development of effective and targeted products for crop protection.
Used in Organic Chemistry:
Benzonitrile, 5-bromo-3-fluoro-2-hydroxyis also used in the production of other organic compounds. Its versatile structure allows it to be a precursor in the synthesis of various organic molecules, which can be further utilized in different chemical and industrial applications.
Safety Considerations:
5-Bromo-3-fluoro-2-hydroxybenzonitrile is a potentially hazardous chemical and should be handled with care, following proper safety protocols. This includes wearing appropriate personal protective equipment, working in a well-ventilated area, and adhering to guidelines for storage and disposal to minimize risks associated with its use.

Upstream product

• 21524-39-0 2,3-difluorobenzonitrile 
• 251300-28-4 5-bromo-3-fluoro-2-hydroxybenzaldehyde 
• 394-50-3 3-fluorosalicylaldehyde 
• 28177-74-4 3-fluoro-2-hydroxybenzonitrile 

Downstream Products

• 1247885-38-6 5-bromo-3-fluoro-2-methoxybenzonitrile 

Relevant articles and documents

PYRAZOLOPYRIMIDINE DERIVATIVE AND USE THEREOF AS PI3K INHIBITOR

The present invention discloses a series of pyrazolopyrimidine derivatives and use thereof in preparing a medicament for treating a disease related to PI3K, and in particular, discloses a derivative compound of formula (I), a tautomer thereof or a pharmaceutically acceptable composition thereof.

HETEROCYCLIC COMPOUND, APPLICATION THEREOF AND PHARMACEUTICAL COMPOSITION COMPRISING SAME

Disclosed in the present invention are a heterocyclic compound, an application thereof and a pharmaceutical composition comprising the same. Provided by the present invention are a heterocyclic compound represented by formula I or a pharmaceutically acceptable salt thereof. The compound has a novel structure and a good inhibitory activity against autotaxin (ATX).

TANK-BINDING KINASE INHIBITOR COMPOUNDS

Compounds having the following formula (I) and methods of their use and preparation are disclosed:

COMPOUNDS FOR TREATING DISORDERS MEDIATED BY METABOTROPIC GLUTAMATE RECEPTOR 5, AND METHODS OF USE THEREOF

Provided herein are compounds and methods of synthesis thereof. The compounds provided herein are useful for the treatment, prevention, and/or management of various disorders, such as neurological disorders, psychiatric disorders, neuromuscular disorders, gastrointestinal disorders, lower urinary tract disorder, and cancer. Compounds provided herein modulate the activity of metabotropic glutamate receptor 5 (mGluR5) in the central nervous system or the periphery. Pharmaceutical formulations containing the compounds and their methods of use are also provided herein.

REMEDY OR PREVENTIVE FOR DIGESTIVE ULCER

An object of the present invention is to provide an agent for treating or preventing digestive ulcer that is effective even to ulcer of small intestine and others, for which gastric acid secretion inhibitors such as proton pump inhibitors are ineffective, and is superior to allopurinol in the efficaciousness and the safety. The pharmaceutical composition of the present invention comprising a non-purine xanthine oxidase inhibitor as the active ingredient is useful as an agent for treating or preventing ulcer that forms in digestive tracts by the attack of gastric acid, pepsin, stress, Helicobacter pylori bacteria, NSAID, etc. In particular, it is useful as an ulcer remedy heretofore unknown in the art as it is effective even for ulcer in small intestine for which gastric/duodenal ulcer remedies that inhibit gastric acid secretion such as proton pump inhibitors are ineffective.

2-PHENYLPYRIDINE DERIVATIVE

The present invention relates to a novel 2-phenylpyridine derivative or a salt thereof, wherein the pyridine ring is substituted with a carboxyl group or the like and the benzene ring has an electron-withdrawing group such as a cyano group and an electron-donating group such as a substituted alkoxy group at the same time. Since the compound of the invention has good xanthine oxidase-inhibitory action and uric acid-lowering action and does not have a structure derived from nucleic acid, the compound has advantages of high safety and excellent effects as compared with conventional compounds and is useful as a therapeutic or preventive agent for hyperuricemia, gout, inflammatory bowel diseases, diabetic kidney diseases, diabetic retinopathy, or the like.

2-PHENYLTHIOPHENE DERIVATIVE

The present invention relates to a 2-phenylthiophene derivative or a salt thereof, wherein the thiophene ring is substituted with a carboxyl group or the like and the benzene ring has an electron-withdrawing group such as a cyano group and an electron-donating group such as a substituted alkoxy group at the same time. Since the compound of the invention has good xanthine oxidase-inhibitory action and uric acid-lowering action and does not have a structure derived from nucleic acid, the compound has advantages of high safety and excellent effects as compared with conventional compounds and is useful as a therapeutic or preventive agent for hyperuricemia, gout, inflammatory bowel diseases, diabetic kidney diseases, diabetic retinopathy, or the like.

2-PHENYLPYRIDINE DERIVATIVE

A 2-phenylpyridine derivative represented by the following general formula (I) or a salt thereof. The compounds have satisfactory xanthine oxidase inhibitory activity and uric acid-lowering activity and are useful as a therapeutic or preventive agent for hyperuricemia, gout, inflammatory intestinal diseases, diabetic nephropathy, diabetic retinopathy, etc. [The symbols in the formula have the following meanings: R1: H, etc.; R2: -CO2H, etc.; R3 and R4: H, etc.; R5: -CN, etc.; R6: H, etc.; X: -O-, -N(R8)-, or -S-; (provided that the groups represented by R5 and -X-R7 are bonded in a meta position or the para position to the pyridyl group) R8: H, etc.; R7: C1-8 linear or branched alkyl, etc.; Y: a bond, etc.; and R9, R10, and R11: H, etc. (provided that when X is -N(R8)-, then R8 may be bonded to R7 to form a nitrogenous saturated heterocycle in cooperation with the adjacent nitrogen atom).]