21524-39-0

Usage

Uses

Used in Pharmaceutical Industry:
2,3-Difluorobenzonitrile is used as an intermediate compound for the synthesis of various pharmaceuticals. Its unique structure and properties make it a valuable building block in the development of new drugs with potential therapeutic applications.
Used in Chemical Synthesis:
2,3-Difluorobenzonitrile is used as a key intermediate in the preparation of complex organic molecules, such as difluorophenyl-1,2,3,5-dithiadiazolyl and cyanophenoxazines. These compounds have potential applications in various fields, including materials science and pharmaceuticals.
Used in Research and Development:
The electronic transitions of 2,3-difluorobenzonitrile have been studied extensively, providing valuable insights into its chemical properties and potential applications. This research contributes to the broader understanding of similar compounds and their potential uses in various industries.

InChI:InChI=1/C13H19FN2O/c14-13-3-1-2-12(10-13)11-16-6-4-15(5-7-16)8-9-17/h1-3,10,17H,4-9,11H2

Upstream product

• 2646-91-5 2,3-difluorobenzaldehyde 
• 367-11-3 ortho-difluorobenzene 
• 121219-16-7 (2,3-difluorophenyl)boronic acid 
• 33192-09-5 N-ethyl-4-thiocyanatobenzenamine 

Downstream Products

• 119584-79-1 2,4-diamino-8-fluoroquinazoline 
• 18355-75-4 2,3-difluorobenzamide 
• 870562-65-5 3-fluoro-2-1,2,4-triazol-1-yl-benzonitrile 
• 870562-63-3 3-fluoro-2-(1,1-dioxo-1λ6-[1,2]thiazinan-2-yl)benzonitrile 
• 507239-82-9 3-fluoro-2-(2-methyl-4-pyrrolidin-1-yl-quinolin-7-ylmethoxy)-benzonitrile 
• 903579-11-3 (R)-3-fluoro-2-[2-chloro-5-(5-oxo-pyrrolidin-3-yl)-phenoxy]-benzonitrile 
• 28177-74-4 3-fluoro-2-hydroxybenzonitrile 
• 756839-23-3 2-Azido-5-fluorobenzonitrile 
• 1205637-19-9 ethyl 2,3-difluorobenzenecarboxyimidate hydrochloride 

Relevant academic research and scientific papers

PYRIMIDONE DERIVATIVES AS SELECTIVE CYTOTOXIC AGENTS AGAINST HIV INFECTED CELLS

The present disclosure is directed to pyrimidone derivatives of Formula I and their use for selectively killing HIV infected GAG-POL expressing cells without concomitant cytotoxicity to HIV nave cells, and for the treatment or prophylaxis of infection by HIV, or for the treatment, prophylaxis or delay in the onset or progression of AIDS or AIDS Related Complex (ARC).

PYRIDINONE DERIVATIVES AS SELECTIVE CYTOTOXIC AGENTS AGAINST HIV INFECTED CELLS

The present disclosure is directed to pyridinone derivatives of Formula I and their use for selectively killing HIV infected GAG-POL expressing cells without concomitant cytotoxicity to HIV nave cells, and for the treatment of infection by HIV, or for the treatment, prophylaxis or delay in the onset or progression of AIDS or AIDS Related Complex (ARC).

Palladium-Catalyzed Late-Stage Direct Arene Cyanation

Methods for direct benzonitrile synthesis are sparse, despite the versatility of cyano groups in organic synthesis and the importance of benzonitriles for the dye, agrochemical, and pharmaceutical industries. We report the first general late-stage aryl C–H cyanation with broad substrate scope and functional-group tolerance. The reaction is enabled by a dual-ligand combination of quinoxaline and an amino acid-derived ligand. The method is applicable to direct cyanation of several marketed small-molecule drugs, common pharmacophores, and organic dyes. Benzonitriles are some of the most versatile building blocks for organic synthesis, in particular in the pharmaceutical industry, but general methods to make them by direct C–H functionalization are unknown. In this issue of Chem, Ritter and coworkers describe a late-stage aryl C–H cyanation with broad substrate scope and functional-group tolerance, enabled by a palladium-dual-ligand catalyst system. The reaction may serve for the late-stage modification of drug candidates. Aryl nitriles constitute an important class of organic compounds that are widely found in natural products, pharmaceuticals, agricultural chemicals, dyes, and materials. Moreover, nitriles are versatile building blocks to access numerous other important molecular structure groups. However, no general method for direct aromatic C–H cyanation is known. All approaches to date require either an appropriate directing group or reactive electron-rich substrates, such as indoles, which limit their synthetic applications. Here we describe an undirected, palladium-catalyzed late-stage aryl C–H cyanation reaction for the synthesis of complex aryl nitriles that would otherwise be more challenging to produce. The wide substrate scope and good functional-group tolerance of this reaction provide direct and quick access to structural diversity for pharmaceutical and agrochemical development.

Oxidative cyanide-free cyanation on arylboronic acid derivatives using aryl/heteroaryl thiocyanate using novel IL-PdCl4 catalyst under mild condition

An efficient and simple method is reported for the cyanation on arylboronic acid using various simple/indole thiocyanates using a new IL-PdCl4 catalyst. The cascade process involves a coupling reaction without any additive to give a wide range of cyanide derivatives. Cyanation on various arylboronic acids underwent smoothly affording the corresponding arylnitriles in good to high yields.

N-indazolyl[1,2,4]triazolo[1,5-C]pyrimidine-2-sulfonamide herbicides

Substituted N-indazolyl[1,2,4]triazolo[1,5]-c-pyrimidine-2-sulfonamide compounds, such as N-(4-fluoro-1-methyl-3-indazolyl)-5-ethoxy-7-fluoro[1,2,4]triazolo[1,5-c]pyrimidine-2-sulfonamide, were prepared by condensation of a 2-chlorosulfonyl[1,2,4]triazolo[1,5-c]pyrimidine compound, such as 2-chlorosulfonyl-5-ethoxy-7-fluoro[1,2,4]triazolo[1,5-c]pyrimidine, with a substituted 3-aminoindazole compound, such as 3-amino-4-fluoro-1-methylindazole, and found to possess herbicidal utility.