879550-54-6Relevant articles and documents
Preparation method of thiazolyl dihydropyrazole compound and application thereof
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, (2019/02/10)
The invention relates to a hydrochloric acid pickling corrosion inhibitor for carbon steel, in particular to a preparation method of a thiazolyl dihydropyrazole compound and application thereof. The thiazolyl dihydropyridine compound is 3-phenyl-1-(4-phen
Reaction of hydrazonoyl halides 52:1 synthesis and antimicrobial activity of some new pyrazolines and 1,3,4-thiadiazolines
Abdelhamid, Abdou O.,Sayed, Abdelwahed R.
, p. 1767 - 1777 (2008/03/18)
[5-Substituted 2-(3-phenyl-5-substituted 2-pyrazolinyl)(1,3-thiazol-4-yl)] phenyldiazene and 2,3-dihydro-1,3,4-thiadiazoles were synthesized via reactions of hydrazonoyl halides with 5-substituted-3-phenyl-4,5-dihydropyrazole-1- carboximidothionic acid an
Synthesis of and pharmacological studies on the antidepressant and anticonvulsant activities of some 1,3,5-trisubstituted pyrazolines
Ruhoglu, Ozan,Oezdemir, Zuhal,Calis, Uensal,Guemuesel, Buelent,Bilgin, Abdullah Altan
, p. 431 - 436 (2007/10/03)
Eighteen 1-phenyl-, 1-thiocarbamoyl- and 1-N-substitutedthiocarbamoyl-3- phenyl-5-heteroaryl-2-pyrazoline derivatives were synthesized and tested for their antidepressant and anticonvulsant activities. Their chemical structures were proved by spectral and microanalysis. The antidepressant activities of the compounds were investigated by the "forced swimming test". Results showed that compounds II-a,b,c, III-1b,1c,4a showed activities equivalent to or higher than pargyline hydrochloride (CAS 306-07-0) and tranylcypromine sulfate (CAS 13492-01-8) that were used as reference antidepressant drugs. Anticonvulsant activities of the compounds were determined by maximal electroshock seizure (MES), subcutaneous metrazol (ScMet.) and rotarod toxicity tests in mice according to the phase I tests of the Antiepileptic Drug Development programme. Compounds I-a, II-a,b,c, III-1b,2a,2c were found protective against MES and III-1b,1c,2a,2c were found protective against ScMet. ECV · Editio Cantor Verlag.