- Directing-Group-Based Strategy Enabling Intermolecular Heck-Type Reaction of Cycloketone Oxime Esters and Unactivated Alkenes
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A new type of coupling between unactivated olefins and nonstabilized alkyl radicals was achieved, which enabled the first intermolecular Heck-type reaction of cycloketone oxime esters and unactivated alkenes. This directing-group-based strategy was compatible with various unactivated alkenes and cyclobutanone-, cyclopentanone-, and cyclohexanone-derived oxime esters. Density functional theory calculations showed that both excellent regioselectivities and good diastereoselectivities could be ascribed to the 2-butanol-assisted concerted H-OBz elimination of the conformationally strained metallacyclic transition state.
- Cheng, Gui-Juan,Deng, Yi,Fu, Junkai,Li, Xuexiang,Wang, Hongwei,Zhao, Chunyang,Zhou, Yu
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supporting information
p. 3524 - 3530
(2020/04/30)
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- Practical Direct α-Arylation of Cyclopentanones by Palladium/Enamine Cooperative Catalysis
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Direct arylation of cyclopentanones has been a long-standing challenge because of competitive self-aldol condensation and multiple arylations. Reported herein is a direct mono-α-C-H arylation of cyclopentanones with aryl bromides which is enabled by palla
- Xu, Yan,Su, Tianshun,Huang, Zhongxing,Dong, Guangbin
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supporting information
p. 2559 - 2563
(2016/02/18)
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- Substituted hexahydropyrrolo[1,2-a]-quinolines, hexahydro-1H-pyrido[1,2-a]-q
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Tricyclic benzo fused compounds of the formula STR1 and pharmaceutically acceptable cationic and acid addition salts thereof, wherein n is zero, 1 or 2, and t is 1 or 2; M is CH or N, R1 is H or certain acyl groups; Q is CO2 R4, COR5, C(OR7)R5 R6, CN, CONR9 R10, CH2 NR9 R10, CH2 NHCOR11, CH2 NHSO2 R12, 5-tetrazolyl or when n is 1, Q and OR1 together form a lactone or certain reduced derivatives thereof; and Z is certain alkyl, alkoxy, alkoxyalkyl, aralkyl, aralkoxy, aryloxyalkyl or aralkoxyalkyl groups, are valuable central nervous system active agents, methods for their use, pharmaceutical compositions containing them and certain intermediates therefor.
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- PHOTOLYSIS OF CIS- AND TRANS-2-(3,5-DIMETHOXYPHENYL)CYCLOPENTYL METHANESULFONATE. STEREOELECTRONIC REQUIREMENT FOR PHOTOSOLVOLYSIS
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On irradiation in methanol, trans-2-(3,5-dimethoxyphenyl)cyclopentyl methanesulfonate underwent photosolvolysis whereas the cis-isomer did not; thus, for photosolvolysis there exists a trans-requirement of excited aryl group and leaving group.
- Jaeger, David A.,Bernhardt, Emily A.
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p. 4521 - 4524
(2007/10/02)
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