885274-64-6

Basic information

• Product Name: 2-(2-METHOXY-PHENYL)-OXAZOLE-4-CARBOXYLIC ACID ETHYL ESTER
• Synonyms: 2-(2-METHOXY-PHENYL)-OXAZOLE-4-CARBOXYLIC ACID ETHYL ESTER
• CAS NO: 885274-64-6
• Molecular Formula: C₁₃H₁₃NO₄
• Molecular Weight: 247.25
• Mol File: 885274-64-6.mol

Chemical Properties

• Boiling Point: 384.9±48.0 °C(Predicted)
• Appearance: /
• Density: 1.182±0.06 g/cm3(Predicted)
• PKA: -1?+-.0.10(Predicted)
• CAS DataBase Reference: 2-(2-METHOXY-PHENYL)-OXAZOLE-4-CARBOXYLIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-METHOXY-PHENYL)-OXAZOLE-4-CARBOXYLIC ACID ETHYL ESTER(885274-64-6)
• EPA Substance Registry System: 2-(2-METHOXY-PHENYL)-OXAZOLE-4-CARBOXYLIC ACID ETHYL ESTER(885274-64-6)

Safety Data

• Hazardous Substances Data: 885274-64-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research:
2-(2-Methoxy-phenyl)-oxazole-4-carboxylic acid ethyl ester is used as a key intermediate in the synthesis of various pharmaceutical compounds for the treatment of different diseases. Its unique structure allows for the development of new drugs with improved efficacy and reduced side effects.
Used in Organic Synthesis:
In the field of organic synthesis, 2-(2-Methoxy-phenyl)-oxazole-4-carboxylic acid ethyl ester serves as a versatile building block for the creation of complex organic molecules. Its reactivity and functional groups enable the formation of a wide range of chemical compounds with diverse applications.
Used in Drug Development:
2-(2-Methoxy-phenyl)-oxazole-4-carboxylic acid ethyl ester is used as a potential candidate in drug development due to its potential biological activities. Researchers are studying its properties to explore its use in the treatment of various diseases, making it a promising compound for future pharmaceutical applications.

Upstream product

• 23012-14-8 oxazole-4-carboxylic acid ethyl ester 
• 1207429-55-7 2-methoxyphenyl 1H-imidazole-1-sulfonate 
• 578-57-4 2-bromoanisole 
• 529-28-2 4-iodoanisol 

Downstream Products

• 1582221-40-6 ethyl 2-(2-methoxyphenyl)-5-phenyloxazole-4-carboxylate 

Relevant articles and documents

Radical C-H Arylation of Oxazoles with Aryl Iodides: Dppf as an Electron-Transfer Mediator for Cs2CO3

A radical C-H arylation reaction of oxazoles with (hetero)aryl iodides using Cs2CO3 as base/electron donor and 1,1′-bis(diphenylphosphino) ferrocene (dppf) as a catalytic SET mediator is reported. The overall reaction likely follows the general base-promoted homolytic aromatic substitution mechanism through a radical-chain pathway. DFT calculations suggest that dppf forms a complex with CsCO3-, enhancing its SET reducing ability to generate an aryl radical from ArI.

C-H bond arylations and benzylations on oxazol(in)es with a palladium catalyst of a secondary phosphine oxide

An air-stable, well-defined palladium complex derived from secondary phosphine oxide (SPO) (1-Ad)2P(O)H enabled efficient C-H bond functionalizations with ample scope, which set the stage for direct arylations and benzylations of (benz)oxazoles, as well as unprecedented palladium-catalyzed C-H bond arylations on nonaromatic oxazolines.

Palladium-catalyzed direct arylations, alkenylations, and benzylations through C-H bond cleavages with sulfamates or phosphates as electrophiles

(Figure Presented) catalytic system comprised of Pd(OAc)2 and bldentate ligand dppe enabled first direct arylatlons with moisture-stable aryl sulfamates as electrophlles, and proved applicable to unprecedented C-H bond functlonallzations with e