886370-75-8Relevant articles and documents
THIAZOLE CARBOXAMIDE COMPOUNDS AND USE THEREOF FOR THE TREATMENT OF MYCOBACTERIAL INFECTIONS
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Page/Page column 58; 59, (2021/04/02)
Provided herein are compounds of Formula (I) and Formula (II) as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of tuberculosis.
CHEMICAL COMPOUNDS
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Page/Page column 104, (2020/06/01)
A compound of formula (I), wherein Ar1, R21, R23, R24, R25, R26, R27, A, X, Y and W are as defined herein. The compounds of the present invention are inhibitors of hematopoietic prostaglandin D synthase (H-PGDS) and can be useful in the treatment of Duchenne muscular dystrophy. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting H-PGDS activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.
Discovery of Pyrazolopyridones as a Novel Class of Gyrase B Inhibitors Using Structure Guided Design
Cross, Jason B.,Zhang, Jing,Yang, Qingyi,Mesleh, Michael F.,Romero, Jan Antoinette C.,Wang, Bin,Bevan, Doug,Poutsiaka, Katherine M.,Epie, Felix,Moy, Terence,Daniel, Anu,Shotwell, Joseph,Chamberlain, Brian,Carter, Nicole,Andersen, Ole,Barker, John,Ryan, M. Dominic,Metcalf, Chester A.,Silverman, Jared,Nguyen, Kien,Lippa, Blaise,Dolle, Roland E.
supporting information, p. 374 - 378 (2016/05/19)
The ATPase subunit of DNA gyrase B is an attractive antibacterial target due to high conservation across bacteria and the essential role it plays in DNA replication. A novel class of pyrazolopyridone inhibitors was discovered by optimizing a fragment screening hit scaffold using structure guided design. These inhibitors show potent Gram-positive antibacterial activity and low resistance incidence against clinically important pathogens.
Novel Heteroaromatic Amides And Thioamides As Pesticides
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Page/Page column 21, (2011/05/05)
The present application relates to novel amides and thioamides, to processes for preparation thereof and to use thereof for controlling animal pests, in particular arthropods and especially insects.