887584-46-5

Basic information

• Product Name: 5-(4-AMINO-3-BROMOPHENYL)-1,3,4-OXADIAZOLE-2-THIOL
• Synonyms: 5-(4-AMINO-3-BROMOPHENYL)-1,3,4-OXADIAZOLE-2-THIOL
• CAS NO: 887584-46-5
• Molecular Formula: C₈H₆BrN₃OS
• Molecular Weight: 272.12
• Mol File: 887584-46-5.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-(4-AMINO-3-BROMOPHENYL)-1,3,4-OXADIAZOLE-2-THIOL(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-AMINO-3-BROMOPHENYL)-1,3,4-OXADIAZOLE-2-THIOL(887584-46-5)
• EPA Substance Registry System: 5-(4-AMINO-3-BROMOPHENYL)-1,3,4-OXADIAZOLE-2-THIOL(887584-46-5)

Safety Data

• Hazardous Substances Data: 887584-46-5(Hazardous Substances Data)

Upstream product

• 75-15-0 carbon disulfide 
• 106896-49-5 methyl 4-amino-3-bromobenzoate 
• 619-45-4 4-methoxycarbonyl aniline 

Downstream Products

• 1312698-82-0 4-(2-bromo-4-(5-mercapto-1,3,4-oxadiazol-2-yl)phenyl)thiosemicarbazide 

Relevant articles and documents

Synthesis and biological evaluation of a novel human stem/progenitor cells proliferation activator: 4-(4-(5-mercapto-1,3,4-oxadiazol-2-yl)phenyl) thiosemicarbazide (Stemazole)

Stem/progenitor cells are crucial for cell-based therapy and regenerative medicine, and their application in clinical and basic research requires a large supply of cells. To identify effective stem/progenitor cell proliferation activators, we synthesised a series of new 4-(4-(5-mercapto-1,3,4-oxadiazol-2- yl)phenyl) thiosemicarbazide (named Stemazole) derivatives. Preliminary evaluation of the structure-activity relationship (SAR) and the biological activities of the compounds were determined with a luminescent cell viability assay. The identified leading compound, Stemazole, exhibited remarkable proliferation-promoting activity in human hippocampal stem/progenitor cells (HSCs) in a time-dependent and concentration-dependent manner. The proliferation-promoting activity of Stemazole was further confirmed against a panel of human stem/progenitor cells derived from each of the three blastoderm layers. In conclusion, Stemazole is a novel activator of stem cells proliferation.