889451-26-7

Basic information

• Product Name: 3-Iodo-4,7-diazaindole
• Synonyms: 3-Iodo-4,7-diazaindole;7-iodo-5H-pyrrolo[2,3-b]pyrazine
• CAS NO: 889451-26-7
• Molecular Formula: C₆H₄IN₃
• Molecular Weight: 245.02053
• Mol File: 889451-26-7.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-Iodo-4,7-diazaindole(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Iodo-4,7-diazaindole(889451-26-7)
• EPA Substance Registry System: 3-Iodo-4,7-diazaindole(889451-26-7)

Safety Data

• Hazardous Substances Data: 889451-26-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3-Iodo-4,7-diazaindole is used as a key building block for the synthesis of drugs and drug intermediates, leveraging its unique molecular structure to create novel therapeutic agents.
Used in Antibacterial Applications:
3-Iodo-4,7-diazaindole is utilized as an antibacterial agent, exhibiting potential to combat bacterial infections due to its inherent chemical properties that can interfere with bacterial processes.
Used in Antifungal Applications:
3-Iodo-4,7-diazaindole is also applied as an antifungal agent, harnessing its chemical structure to inhibit fungal growth, making it a candidate for treatments against fungal diseases.
Used in Material Science:
3-Iodo-4,7-diazaindole is explored for its use in developing new materials, capitalizing on its chemical and physical properties to enhance material performance in various technological applications.
Used in Bioimaging Applications:
As a fluorescent probe, 3-Iodo-4,7-diazaindole is employed in bioimaging to visualize cellular and molecular processes, providing insights into biological systems due to its fluorescent properties that allow for the tracking of specific targets within living organisms.

InChI:InChI=1S/C6H4IN3/c7-4-3-10-6-5(4)8-1-2-9-6/h1-3H,(H,9,10)

Upstream product

• 4745-93-1 pyrrolo<2,3-b>pyrazine 

Downstream Products

• 1316228-34-8 tert-butyl 7-(1-benzyltriazol-4-yl)pyrrolo[2,3-b]pyrazine-5-carboxylate 
• 1316228-57-5 7-(1-benzyl-1H-1,2,3-triazol-4-yl)-5H-pyrrolo-[2,3-b]pyrazine 

Relevant articles and documents

INHIBITORS OF INFLUENZA VIRUS REPLICATION AND USES THEREOF

The invention provides a class of compounds as inhibitors of influenza virus replication, preparation methods thereof, pharmaceutical compositions containing these compounds, and uses of these compounds and pharmaceutical compositions thereof in the treatment of influenza.

7-(1,2,3-TRIAZOL-4-YL) PYRROLO [2,3-B] PYRAZINE DERIVATIVES

Compounds of the formula (I), in which R1, R2 and R3 have the meanings indicated in Claim 1, are inhibitors of PDK1 and cell proliferation/cell vitality and can be employed for the treatment of tumours.

Rapid preparation of triazolyl substituted NH-heterocyclic kinase inhibitors via one-pot Sonogashira coupling-TMS-deprotection-CuAAC sequence

The one-pot, three-component Sonogashira coupling-TMS-deprotection-CuAAC ("click") sequence is the key reaction for the rapid synthesis of triazolyl substituted N-Boc protected NH-heterocycles, such as indole, indazole, 4-, 5-, 6-, and 7-azaindoles, 4,7-diazaindole, 7-deazapurines, pyrrole, pyrazole, and imidazole. Subsequently, the protective group was readily removed to give the corresponding triazolyl derivatives of these tremendously important NH-heterocycles. All compounds have been tested in a broad panel of kinase assays. Several compounds, 8f, 8h, 8k, and 8l, have been shown to inhibit the kinase PDK1, a target with high oncology relevance, and thus they are promising lead structures for the development of more active derivatives. The X-ray structure analysis of compound 8f in complex with PDK1 has revealed the detailed binding mode of the molecule in the kinase. The Royal Society of Chemistry 2011.