893738-68-6

Basic information

• Product Name: 5-cyclopropylpyridin-2-amine
• Synonyms: 5-cyclopropylpyridin-2-amine
• CAS NO: 893738-68-6
• Molecular Formula: C₈H₁₀N₂
• Molecular Weight: 134.1784
• Mol File: 893738-68-6.mol

Chemical Properties

• Boiling Point: 273.5±28.0 °C(Predicted)
• Appearance: /
• Density: 1.188±0.06 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 6.88±0.13(Predicted)
• CAS DataBase Reference: 5-cyclopropylpyridin-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-cyclopropylpyridin-2-amine(893738-68-6)
• EPA Substance Registry System: 5-cyclopropylpyridin-2-amine(893738-68-6)

Safety Data

• Hazardous Substances Data: 893738-68-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research:
5-cyclopropylpyridin-2-amine is used as a key intermediate in the synthesis of new drugs for targeting specific receptors or enzymes. Its unique structural features allow for the development of compounds with novel mechanisms of action, potentially leading to more effective treatments for various diseases.
Used in Medicinal Chemistry:
As a pyridine derivative, 5-cyclopropylpyridin-2-amine is used as a building block in the design and synthesis of bioactive molecules. Its presence in a molecule can influence the pharmacokinetic and pharmacodynamic properties, making it an important component in the creation of new therapeutic agents.
Used in Organic Synthesis:
5-cyclopropylpyridin-2-amine is utilized as a reagent in organic synthesis, where its unique chemical properties can be harnessed to facilitate specific reactions or to improve the yield and selectivity of synthetic processes.
Used in Material Science:
5-cyclopropylpyridin-2-amine's unique structural and chemical properties make it a potential candidate for the development of new materials with specialized properties, such as improved stability, reactivity, or selectivity in various applications.

Upstream product

• 1072-97-5 5-bromo-2-pyridylamine 
• 411235-57-9 cyclopropylboronic acid 
• 2622-14-2 tricyclohexylphosphine 
• 84249-14-9 2-amino-4-bromopyridine 

Downstream Products

• 1609551-40-7 2-(2-bromophenyl)-N-(5-cyclopropylpyridin-2-yl)acetamide 
• 1086381-39-6 2-bromo-4-cyclopropylpyridine 
• 1142197-14-5 2-bromo-5-cyclopropylpyridine 
• 1063960-83-7 5-cyclopropyl-2-methoxypyridine 
• 1042986-18-4 2-chloro-5-cyclopropylpyridine 
• 1329669-76-2 [8-(4-chloro-phenyl)-6-cyclopropyl-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-[1-(6-methyl-pyrimidin-4-yl)-piperidin-4-yl]-amine 
• 1319068-95-5 2-bromo-8-(4-chloro-phenyl)-6-cyclopropyl-[1,2,4]triazolo[1,5-a]pyridine 
• 1319068-94-4 8-(4-Chloro-phenyl)-6-cyclopropyl-[1,2,4]triazolo[1,5-a]pyridin-2-ylamine 
• 1319066-73-3 [8-(4-chloro-phenyl)-6-cyclopropyl-[1,2,4]triazolo[1,5-a]pyridin-2-yl]-[3-methoxy-4-(4-methyl-imidazol-1-yl)-phenyl]-amine 

Relevant articles and documents

HETEROARYL PLASMA KALLIKREIN INHIBITORS

The present invention provides compounds and compositions thereof which are useful as inhibitors of plasma kallikrein and which exhibit desirable characteristics for the same.

PLASMA KALLIKREIN INHIBITORS AND USES THEREOF

The present invention provides compounds and compositions thereof which are useful as inhibitors of plasma kallikrein and which exhibit desirable characteristics for the same.

SOLID FORMS OF INHIBITORS OF PLASMA KALLIKREIN

The present invention provides compounds and compositions thereof which are useful as inhibitors of Plasma Kallikrein (pKal) and which exhibit desirable characteristics for the same.

FORMS AND COMPOSITIONS OF INHIBITORS OF PLASMA KALLIKREIN

The present invention provides solid forms of compound (1) and compositions thereof which are useful as inhibitors of Plasma Kallikrein (pKal) and which exhibit desirable characteristics for the same.

COMPOUNDS FOR USE IN TREATING NEUROLOGICAL DISORDERS

Provided are methods for treating neurological disorders using compounds of Formula (I), and pharmaceutically acceptable salts and compositions thereof.

INHIBITORS OF PLASMA KALLIKREIN AND USES THEREOF

The present invention provides compounds and compositions thereof which are useful as inhibitors of plasma kallikrein and which exhibit desirable characteristics for the same.

P300/CBP HAT INHIBITORS

Provided are compounds of Formula (I): and pharmaceutically acceptable salts and compositions thereof, which are useful for treating a variety of conditions associated with histone acetyltransferase (HAT).

TYK2 INHIBITORS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.

NOVEL BICYCLIC HETEROCYCLIC COMPOUND

Provided are a novel compound having a superior inhibitory action on KAT-II, a production method thereof, use thereof, and a pharmaceutical composition containing the aforementioned compound and the like. A compound represented by the formula (I) or a pharmacologically acceptable salt thereof. wherein each symbol is as defined in the DESCRIPTION.

Synthesis of bromocyclopropylpyridines via the Sandmeyer reaction

The reactions of 2-amino-5-cyclopropylpyridine with organic nitrites in the presence of copper(II) halides in various organic solvents were investigated. Optimal reaction conditions for the Sandmeyer reaction were developed and successfully applied to the synthesis of useful building blocks, bromo and chlorocyclopropylpyridines. Aminocyclopropylpyridines were synthesized in high yields from the corresponding aminobromopyridines under standard Suzuki coupling conditions.