893738-68-6Relevant articles and documents
HETEROARYL PLASMA KALLIKREIN INHIBITORS
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Paragraph 0179; 0189; 0196; 0209, (2021/03/19)
The present invention provides compounds and compositions thereof which are useful as inhibitors of plasma kallikrein and which exhibit desirable characteristics for the same.
PLASMA KALLIKREIN INHIBITORS AND USES THEREOF
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Paragraph 0237; 0238; 0296; 0297; 0544; 0586, (2021/03/19)
The present invention provides compounds and compositions thereof which are useful as inhibitors of plasma kallikrein and which exhibit desirable characteristics for the same.
SOLID FORMS OF INHIBITORS OF PLASMA KALLIKREIN
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Paragraph 0091-0092, (2021/10/22)
The present invention provides compounds and compositions thereof which are useful as inhibitors of Plasma Kallikrein (pKal) and which exhibit desirable characteristics for the same.
FORMS AND COMPOSITIONS OF INHIBITORS OF PLASMA KALLIKREIN
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Paragraph 0247, (2021/10/22)
The present invention provides solid forms of compound (1) and compositions thereof which are useful as inhibitors of Plasma Kallikrein (pKal) and which exhibit desirable characteristics for the same.
COMPOUNDS FOR USE IN TREATING NEUROLOGICAL DISORDERS
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Paragraph 00130-00131, (2021/02/05)
Provided are methods for treating neurological disorders using compounds of Formula (I), and pharmaceutically acceptable salts and compositions thereof.
INHIBITORS OF PLASMA KALLIKREIN AND USES THEREOF
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, (2019/09/30)
The present invention provides compounds and compositions thereof which are useful as inhibitors of plasma kallikrein and which exhibit desirable characteristics for the same.
P300/CBP HAT INHIBITORS
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Paragraph 00100; 00146-00147, (2019/09/04)
Provided are compounds of Formula (I): and pharmaceutically acceptable salts and compositions thereof, which are useful for treating a variety of conditions associated with histone acetyltransferase (HAT).
TYK2 INHIBITORS AND USES THEREOF
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Paragraph 00567; 00568, (2018/04/27)
The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.
NOVEL BICYCLIC HETEROCYCLIC COMPOUND
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Paragraph 0586; 0587, (2018/09/27)
Provided are a novel compound having a superior inhibitory action on KAT-II, a production method thereof, use thereof, and a pharmaceutical composition containing the aforementioned compound and the like. A compound represented by the formula (I) or a pharmacologically acceptable salt thereof. wherein each symbol is as defined in the DESCRIPTION.
Synthesis of bromocyclopropylpyridines via the Sandmeyer reaction
Striela, Romualdas,Urbelis, Gintaras,Sūd?ius, Jurgis,Ston?ius, Sigitas,Sadzevi?ien?, Rita,Labanauskas, Linas
supporting information, p. 1681 - 1683 (2017/04/06)
The reactions of 2-amino-5-cyclopropylpyridine with organic nitrites in the presence of copper(II) halides in various organic solvents were investigated. Optimal reaction conditions for the Sandmeyer reaction were developed and successfully applied to the synthesis of useful building blocks, bromo and chlorocyclopropylpyridines. Aminocyclopropylpyridines were synthesized in high yields from the corresponding aminobromopyridines under standard Suzuki coupling conditions.