898805-58-8Relevant articles and documents
Convenient preparation of 4-aryl-2-(heteroarylamino)pyrimidines and 4-anilino-2-(heteroarylamino)pyrimidines
Bliss, Brian I.,Ahmed, Feryan,Iyer, Subashree,Lin, Weimin,Walker, Joel,Zhao, He
supporting information; experimental part, p. 3259 - 3262 (2010/07/10)
4-Aryl-2-anilinopyrimidines and 2,4-dianilinopyrimidines are privileged structures found in many drug-like molecules and biologically active compounds. A method for the quick assembly of novel 4-aryl- and 4-anilino-2-(heteroarylamino)pyrimidines via Buchwald-Hartwig N-arylations at elevated temperatures under sealed tube conditions is reported. This method's convenience and practicality is demonstrated through the preparation of several novel non-nucleoside reverse transcriptase inhibitor (NNRTI) analogues.
Development of N-2,4-pyrimidine-N-phenyl-N′-phenyl ureas as inhibitors of tumor necrosis factor alpha (TNF-α) synthesis. Part 1
Brugel, Todd A.,Maier, Jennifer A.,Clark, Michael P.,Sabat, Mark,Golebiowski, Adam,Bookland, Roger G.,Laufersweiler, Matthew J.,Laughlin, Steven K.,VanRens, John C.,De, Biswanath,Hsieh, Lily C.,Mekel, Marlene J.,Janusz, Michael J.
, p. 3510 - 3513 (2007/10/03)
A new class of tumor necrosis factor alpha (TNF-α) synthesis inhibitors based on an N-2,4-pyrimidine-N-phenyl-N′-phenyl urea scaffold is described. Many of these compounds showed low-nanomolar activity against lipopolysaccharide stimulated TNF-α productio
