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N-(2-Pyridylamino)ethanol is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

89943-04-4

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89943-04-4 Usage

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N-(2-Pyridylamino)ethanol (cas# 89943-04-4) is a compound useful in organic synthesis.

Check Digit Verification of cas no

The CAS Registry Mumber 89943-04-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 8,9,9,4 and 3 respectively; the second part has 2 digits, 0 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 89943-04:
(7*8)+(6*9)+(5*9)+(4*4)+(3*3)+(2*0)+(1*4)=184
184 % 10 = 4
So 89943-04-4 is a valid CAS Registry Number.
InChI:InChI=1/C7H10N2O/c10-6-5-9-7-3-1-2-4-8-7/h1-4,10H,5-6H2,(H,8,9)

89943-04-4 Well-known Company Product Price

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  • Aldrich

  • (CBR01241)  2-(Pyridin-2-ylamino)ethanol  AldrichCPR

  • 89943-04-4

  • CBR01241-1G

  • 966.42CNY

  • Detail

89943-04-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-(pyridin-2-ylamino)ethanol

1.2 Other means of identification

Product number -
Other names 2-pyridin-2-ylamino-ethanol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:89943-04-4 SDS

89943-04-4Relevant articles and documents

ADENOSINE RECEPTOR BINDING COMPOUNDS

-

Paragraph 00421, (2020/02/06)

The present invention relates to pharmaceutical compounds and compositions of Formula (I) and methods of treatment using the compounds and compositions, especially for the treatment and/or prevention of a proliferation disorder, such as cancer. Compounds of Formula (I) as further described herein are shown modulators of the adenosine A2A receptor and exhibit antiproliferative activity. Accordingly, these compounds are useful to treat proliferative disorders such as cancer, and other adenosine receptor-related conditions including an inflammatory disease, renal disease, diabetes, vascular disease, lung disease, or an autoimmune disease.

An Improved Rapid and Mild Deoxygenation of Amine N-oxides

Rajesh

, p. 486 - 491 (2017/12/29)

An improved mild and selective method for the deoxygenation of a variety of amine N-oxides has been carried out in the presence of silica gel under mild conditions at room temperature to afford corresponding amines in relatively good yields without purification. The reaction is tolerant of a variety of functional groups such as hydroxyl, ester, acid, carbonyl, and cyano groups, as well as halogens. This method would be of great utility to synthesize various pyridines and amines easily.

Novel thermolabile protecting groups with higher stability at ambient temperature

Chmielewski, Marcin K.

supporting information; experimental part, p. 666 - 669 (2012/02/15)

Novel thermolabile hydroxyl protecting groups of increased thermostability are proposed. The stability of these groups at different temperatures ranges has been determined. The 2-pyridyl-N-(2,4-difluorobenzyl)aminoethyl unit was selected as stable at ambient temperature and very labile at increased temperature. The half-life times for the best groups were established. Application of this chemistry to the protection of different hydroxyl groups of thymidine was also demonstrated.

Engineering N-(2-pyridyl)aminoethyl alcohols as potential precursors of thermolabile protecting groups

Chmielewski, Marcin K.,Tykarska, Ewa,Markiewicz, Wojciech T.,Rypniewski, Wojciech

experimental part, p. 603 - 612 (2012/05/04)

Crystal and NMR analyses of four precursors of N-(2-pyridyl) thermolabile protecting group (TPG) were carried out. Two torsion angles have been identified as indicators that predict the molecules' thermolabile properties. Conformation that minimizes the N1...C8 distance is crucial for thermocyclisation. Nucleophilicity of the pyridyl ring is the driving force for the reaction but it is insufficient for thermocyclisation which is dominated by the molecules' ability to adopt a favourable conformation. The pKa value was recorded for all analyzed N-(2-pyridyl)aminoethyl alcohols. However, its effect is small in the determination of thermolability. Based on the analysis that we carried out, N-benzyl N-(2-pyridyl)aminoethyl was selected as a potential precursor of thermolabile carbonate of TPG. The Royal Society of Chemistry and the Centre National de la Recherche Scientifique 2012.

A mild, catalyst-free synthesis of 2-aminopyridines

Poola, Bhaskar,Choung, Wonken,Nantz, Michael H.

, p. 10798 - 10801 (2008/12/23)

Alkylation of 2-mercaptopyridine with 1,2-dibromoethane affords a cyclic dihydrothiazolopyridinium salt that can serve as a precursor of 2-aminopyridines. Its reaction with primary or secondary amines, either neat or in DMSO, under mild conditions gives the title compounds.

Amination of halopyridines on KF-alumina under microwave irradiation

Yang, De-Hong,Yang, Ben-Yong,Chen, Zhen-Chu,Chen, Song-Ying

, p. 600 - 601 (2007/10/03)

A convenient and clean synthesis of halopyridine-2-amines has been provided by amination of halopyridines on KF-alumina under microwave irradiation with good yields.

Synthesis of a β-strand mimetic based on a pyridine scaffold

Blomberg, David,Brickmann, Kay,Kihlberg, Jan

, p. 10937 - 10944 (2007/10/03)

A synthetic route to a 2,4-disubstituted pyridine as a potential β-strand mimetic has been developed and applied in the synthesis of a tripeptidomimetic of Leu-Gly-Gly. The pyridine scaffold replaces the central glycine, and is substituted with analogues

2,3-Dihydroimidazo[1,2-a]pyridines: A new class of enantioselective acyl transfer catalysts and their use in kinetic resolution of alcohols

Birman, Vladimir B.,Uffman, Eric W.,Jiang, Hui,Li, Ximin,Kilbane, Corey J.

, p. 12226 - 12227 (2007/10/03)

The long-known, but previously unexplored 2,3-dihydroimidazo[1,2-a]pyridine (DHIP) has been shown to be a competent acyl transfer catalyst. Its chiral 2-phenyl derivatives obtainable in two steps from commercially available starting materials have proved to be effective acylation catalysts, giving high levels of enantioselectivity (s = 20-85) in kinetic resolution of secondary benzylic alcohols. A transition state model explaining the observed selectivity has been proposed. Copyright

Pyridinium N-,(2'-azinyl)aminides: Regioselective synthesis of 2- alkylaminoazines

Martínez-Barrasa, Valentín,Delgado, Francisca,Burgos, Carolina,Luis García-Navío,Luisa Izquierdo,Alvarez-Builla, Julio

, p. 2481 - 2490 (2007/10/03)

The regioselective alkylation of pyridinium-N-(2f'-azinil)aminides with alkyl halides under mild conditions is described. The alkylation, combined with a reduction of the N-N bond, allows an easy preparation of 2- alkylaminoazines. (C) 2000 Elsevier Science Ltd.

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