1541-40-8

Usage

Type of compound

heterocyclic (consists of a thiazole and a pyridine ring)

Use in medicinal chemistry

building block for the synthesis of biologically active molecules

Use in coordination chemistry

as a ligand

Use in organic synthesis

starting material for the synthesis of complex organic compounds

Pharmacological properties

potential applications in drug discovery and development.

Upstream product

• 2637-34-5 2-Sulfanylpyridine 
• 107-04-0 1-Bromo-2-chloroethane 
• 2637-34-5 pyridine-2-thione 
• 106-93-4 ethylene dibromide 

Downstream Products

• 96989-47-8 1-[2-(3-Oxo-3-phenyl-propylsulfanyl)-ethyl]-1H-pyridin-2-one 
• 96989-43-4 1-(2-Benzylsulfanyl-ethyl)-1H-pyridin-2-one 
• 96989-46-7 1-[2-(2-Oxo-2-phenyl-ethylsulfanyl)-ethyl]-1H-pyridin-2-one 
• 1089733-60-7 N-(2-pyridyl)glycine benzyl ester 
• 19006-83-8 N-vinylpyridine-2-thione 
• 89943-04-4 2-(pyridin-2-ylamino)ethanol 
• 5683-33-0 2-(Dimethylamino)pyridine 
• 33525-72-3 N-butyl-2-pyridylamine 
• 5866-28-4 2-(prop-2-enylamino)pyridine 
• 64138-49-4 N-(1-phenylethyl)pyridin-2-ylamine 

Relevant academic research and scientific papers

A mild, catalyst-free synthesis of 2-aminopyridines

Alkylation of 2-mercaptopyridine with 1,2-dibromoethane affords a cyclic dihydrothiazolopyridinium salt that can serve as a precursor of 2-aminopyridines. Its reaction with primary or secondary amines, either neat or in DMSO, under mild conditions gives the title compounds.

N-Quaternary Heterocyclics: Part XI - Synthesis of 2,3-Dihydrothiazolopyridinium Salts and Their Reactions with Nucleophiles

2,3-Dihydrothiazolopyridinium perchlorates (I, X = Br or ClO4) on reaction with sodium borohydride give 1,1'-(dithiodiethylene)-bis-(III).I (X = ClO4) with aqueous sodium hydroxide forms 2-(2-mercaptoethyl)-2(1H)-pyridone (IV) and 1,1'-(dithiodiethylene)-di-2(1H)-pyridone (V).