- Polyvinylpyrrolidone composition and processes for its production
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A polyvinylpyrrolidone composition in a form of a solid preparation or an aqueous solution, the composition including polyvinylpyrrolidone, ammonia, and a secondary amine, and processes for producing the polyvinylpyrrolidone composition, the first process including heat drying a polyvinylpyrrolidone aqueous solution containing ammonia and a secondary amine to obtain the polyvinylpyrrolidone in a form of a solid preparation, the second process including adding a secondary amine to an aqueous solution containing polyvinylpyrrolidone and ammonia to obtain the polyvinylpyrrolidone composition in a form of an aqueous solution, and the third process including polymerizing N-vinyl-2-pyrrolidone using hydrogen peroxide as a polymerization initiator in a presence of a metal catalyst using ammonia as a promoter in an aqueous medium to obtain the polyvinylpyrrolidone composition in a form of an aqueous solution.
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Page/Page column 5-6
(2008/06/13)
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- Pharmaceutical composition intended in particular for the prevention and the treatment of radiomucositis and chemomucositis
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The invention concerns a pharmaceutical composition designed to adhere to a mucous membrane for preventing or treating radiotherapy-related and chemotherapy-related mucositis, induced by radiotherapy or combined radiochemotherapy, comprising an effective amount of an antiradical compound mixed with a vehicle, which is liquid at room temperature and gels at the mucous membrane temperature and capable of adhering to the mucous membrane by its gelled status.
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- Macromolecular microparticles and methods of production and use
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Microparticles formed by mixing a macromolecule with a polymer at a pH near the isoelectric point of the macromolecule and incubating the mixture in the presence of an energy source for a predetermined length of time. The microparticles are composed of homogeneously distributed, intertwined macromolecule and polymer. Each microparticle allows aqueous fluids to enter and allows solubilized macromolecule and polymer to exit the microparticle and may be formulated to provide a sustained release of macromolecule and polymer from the interior of the microparticle when placed in an appropriate aqueous medium, such as under physiological conditions. Methods of production and methods of use for research, diagnostics and therapeutics are provided.
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- Macromolecular microparticles and methods of production and use
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Microparticles formed by mixing a macromolecule with a polymer at a pH near the isoelectric point of the macromolecule and incubating the mixture in the presence of an energy source for a predetermined length of time. The microparticles are composed of homogeneously distributed, intertwined macromolecule and polymer. Each microparticle allows aqueous fluids to enter and allows solubilized macromolecule and polymer to exit the microparticle and may be formulated to provide a sustained release of macromolecule and polymer from the interior of the microparticle when placed in an appropriate aqueous medium, such as under physiological conditions. Methods of production and methods of use for research, diagnostics and therapeutics are provided.
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- Compositions which contain active substances and are in the form of solid particles
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Compositions which contain active substances and are in the form of solid particles can be obtained by intimately mixing the active substance with a water-soluble melt composed of a) 10-90% by weight of a water-soluble polymer A with a viscosity Va of 1,000-120,000 cps and b) 10-90% by weight of a water-soluble polymer B with a viscosity Vb of 1-500 cps as carrier substance, where the viscosities Va and Vb are those of a 2% by weight aqueous solution at 20° C., measured by the ASTM D 2363-72 capillary method (European Pharmacopoeia, Vol. III, p. 37), and processing the melt with shaping to give the particles.
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- Polymeric X-ray compositions containing iodinated polymeric beads
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Disclosed are x-ray contrast compositions for oral or retrograde examination of the gastrointestinal tract comprising a polymeric material in combination with a divalent cation capable of forming a coating on the gastrointestinal tract and iodinated polymeric, water-insoluble beads having a particle size of from about 0.01 to about 1000μ wherein said iodinated polymeric beads comprise a polymer containing repeating units of the formula (I) STR1 wherein A is a repeating organic unit in the backbone chain of the polymer; and X is an organic moiety containing or iodinated eromatic group and a hydrophilic group, said moiety having an iodine content within the range of from about 40 to about 80 weight percent based or the molecular weight of X, in a pharmaceutically acceptable carrier.
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- Antihypotensive tetrahydro-1H-pyrazolo[5,1-a]isoindoles
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New substituted tetrahydro-1H-pyrazolo[5,1-a]isoindoles of the formula I STR1 in which R1 denotes a hydrogen or halogen atom or an alkoxy group having 1 to 4 carbon atoms, R2, R3 and R4, which can be identical or different, denote a hydrogen atom or an alkyl group having 1 to 4 carbon atoms, or R2 and R3 together denote the ethylene group, and X denotes a nitrogen atom or a methine group, and their acid addition salts have a long-lasting hypertensive effect and can be used as anti-hypotensives.
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- 6-Azaoligocycloalkylmethyleneaminopenam compounds
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6-Amino-penam compounds, having an antimicrobial action, of the formula STR1 in which R1 is an azaoligocycloalkyl radical which is bonded via the ring nitrogen atom and contains at least one endo-bridge atom and a total of 7 to 12 ring atoms and can contain a double bond and/or, if desired, as a further ring hetero-atom, an oxygen atom, or a nitrogen atom which can link the radical X1, where X1 is hydrogen or lower alkyl, and/or, if desired, free, esterified or etherified hydroxyl which is bonded to a ring carbon atom, and in which R2 is free carboxyl or carboxyl esterified by a physiologically detachable group, and salts of such compounds, processes for their preparation, pharmaceutical preparations which contain these compounds, including mixtures of these compounds with other antimicrobial, especially antibacterial and/or antiviral, active ingredients and/or additional substances or substance mixtures which alleviate the symptoms in the case of infections, the use of the novel compounds of the formula I and their salts, and of the novel substance mixtures, for combating micro-organisms and the preparation of corresponding medicaments by non-chemical means.
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- Certain amide derivatives of 2-guanidino-thiazoles and compositions containing same
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Amides acting as histamine H2 receptors antagonists, of formula STR1 wherein X represents a N→O or C-NH-A-B group in which A is CO or SO2 and B is alkyl, phenyl, pyridyl, pyridyl 1-oxide, pyrazinyl or thienyl; their salts; process for their preparation by reacting 2-(2-guanidinothiazol-4-ylmethylthio)ethylamine with a derivative of formula STR2 and optional salification; and pharmaceutical compositions containing same.
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