- Synthesis and Cell Death Mechanism of a Militarin Derivative
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Militarin, a novel anticancer substance from a caterpillar-grown traditional insect-flower (Cordyceps militaris), was previously isolated and characterized as an ether compound of 4-tert-octylphenol and a nonaethylene glycol. Among militarin analogs with different numbers of ethylene glycol substructure, the analog with four ethylene glycol substructure (M4EG) exhibited potent anticancer activities. A facile and scalable synthetic pathway of the M4EG was developed and the mechanism of cell death by the M4EG against lung adenocarcinoma epithelial cell line (A549) was explored. The results of this study showed that apoptosis of M4EG toward A549 cells is mediated by a caspase-dependent death-signaling pathway.
- Chen, Fei,Yoon, Deok Hyo,Reddy, Dinneswara,Han, Changwoo,Choi, Sunga,Cho, Jae Youl,Sung, Gi-Ho,Hwang, Ki-Chul,Kim, Tae Woong,Park, Haeil
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p. 287 - 293
(2016/03/15)
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- Synthesis, self-aggregation and biological properties of alkylphosphocholine and alkylphosphohomocholine derivatives of cetyltrimethylammonium bromide, cetylpyridinium bromide, benzalkonium bromide (C16) and benzethonium chloride
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A series of alkylphosphocholine and alkylphosphohomocholine derivatives of cetyltrimethylammonium bromide, cetylpyridinium bromide, benzalkonium bromide (C16) and benzethonium chloride have been synthesized. Their physicochemical properties were also investigated. The critical micelle concentration (cmc), the surface tension value at the cmc (γcmc), and the surface area at the surface saturation per head group (Acmc) were determined by means of surface tension measurements. The prepared compounds exhibit significant cytotoxic, antifungal and antiprotozoal activities. Alkylphosphocholines and alkylphosphohomocholines possess higher antifungal activity against Candida albicans in comparison with quaternary ammonium compounds in general. However, quaternary ammonium compounds exhibit significantly higher activity against human tumor cells and pathogenic free-living amoebae Acanthamoeba lugdunensis and Acanthamoeba quina compared to alkylphosphocholines. The relationship between structure, physicochemical properties and biological activity of the tested compounds is discussed.
- Luká?, Milo?,Mrva, Martin,Garajová, Mária,Moj?i?ová, Gabriela,Varinská, Lenka,Moj?i?, Ján,Sabol, Marián,Kubincová, Janka,Haragová, Hana,Ondriska, Franti?ek,Devínsky, Ferdinand
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- Method for preparing arylpoly(oxyalkyl) amines
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The invention pertains to a process for preparing an arylpoly(oxyalkyl)compound, wherein the process involves reacting a phenol with a halohydrin, and reacting the reaction product with an amino alkyl halide. The invention seeks to provide a less hazardous alternative to conventional preparation processes where arylpoly(oxyalkyl)compounds are made starting from an extremely toxic and hazardous dihalogeno-polyalkylene ether. The preferred arylpoly(oxyalkyl)compound is benzethonium chloride.
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Page/Page column 4
(2010/11/30)
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- Isolation of bacterial strains that produce the endocrine disruptor, octylphenol diethoxylates, in paddy fields
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Topsoil samples were collected from 36 different paddy fields in West Japan. Each soil sample was incubated with a basal salt-medium containing 0.2% OPPEO. Twelve samples possessed OPPEO-degrading activity, from which twelve cultures of OPPEO-degrading ba
- Nishio, Eriko,Ichiki, Yayoi,Tamura, Hiroto,Morita, Shiro,Watanabe, Katuji,Yoshikawa, Hiromichi
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p. 1792 - 1798
(2007/10/03)
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- Solvent Extraction of Trivalent Yttrium, Holmium, and Erbium by Novel Types of Acidic Organophosphonates
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New types of acidic organophosphonates, HR with different hydrophobic groups, were synthesized in order to investigate their extraction behavior for heavy rare earth elements (Y3+, Ho3+, and Er3+) from aqueous acidic chlor
- Ohto, Keisuke,Inoue, Katsutoshi,Goto, Masahiro,Nakashio, Fumiyuki,Nagasaki, Takeshi,et al.
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p. 2528 - 2535
(2007/10/02)
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