140-66-9

Basic information

• Product Name: 4-tert-Octylphenol
• Synonyms: p-(1,1,3,3-tetramethylbutyl)-pheno;p-(1’,1’,3’,3’-tetramethylbutyl)fenol;p-(tert-octyl)-pheno;Phenol, p-(1,1,3,3-tetramethylbutyl)-;Phenol, p-(tert-octyl)-;phenol,-(1,1,3,3-tetramethylbutyl)-;p-octylphenol;p-Terc.oktylfenol
• CAS NO: 140-66-9
• Molecular Formula: C₁₄H₂₂O
• Molecular Weight: 206.32
• EINECS: 205-426-2
• Product Categories: Industrial/Fine Chemicals;Alkylphenols (Environmental Endocrine Disruptors);Analytical Chemistry;Color Former & Related Compounds;Developer;Environmental Endocrine Disruptors;Functional Materials;Aromatics;Mutagenesis Research Chemicals
• Mol File: 140-66-9.mol

Chemical Properties

• Melting Point: 79-82 °C(lit.)
• Boiling Point: 175 °C30 mm Hg(lit.)
• Flash Point: 145 °C
• Appearance: white powder
• Density: 0.95 g/cm3 (20℃)
• Vapor Pressure: 0.00025mmHg at 25°C
• Refractive Index: 1.5003 (estimate)
• Storage Temp.: Refrigerator
• Solubility: water: slightly soluble0.007g/L at 20°C
• PKA: 10.15±0.15(Predicted)
• Water Solubility: 7mg/L at 20℃
• Stability: Stable. Incompatible with strong oxidizing agents, strong bases.
• BRN: 513992
• CAS DataBase Reference: 4-tert-Octylphenol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-tert-Octylphenol(140-66-9)
• EPA Substance Registry System: 4-tert-Octylphenol(140-66-9)

Safety Data

• Hazard Codes: Xn,N,Xi,F
• Statements: 21-38-41-50/53-67-66-36-11-52/53-68-62-40
• Safety Statements: 26-36-61-60-39-16-9
• RIDADR: 2430
• WGK Germany: 2
• RTECS: SM9625000
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 140-66-9(Hazardous Substances Data)

Usage

Chemical Properties

white powder

Uses

4-tert-Octylphenol (4t-OP) is used in manufacturing processes as an intermediate in the generation of surfactants, synthetic rubber additives, or resins. 4t-OP is also used to manufacture alkylphenol ethoxylates. It is found mainly in detergents, cleaning products, and emulsifiers and less frequently in paints, personal care products, pesticides, paper, pulp, and textiles.

General Description

4-tert-Octylphenol is a potential environmental pollutant and it exhibits toxic and estrogenic effects on mammalian cells. It binds to estrogen receptors and exerts estrogenic actions in vitro. The transformation of the 4-tert-octylphenol upon irradiation at 253.7nm and by hydroxyl radicals generated by the photolysis (λexc = 253.7nm) of hydrogen peroxide in aqueous solution has been studied.

Health effects

4-tert-octylphenol (OP) is an endocrine-disrupting chemical that causes harmful effects to human health.a common environmental pollutant showing weak estrogenic effects. 4-tert-Octylphenol has been shown to cause harm to the male reproductive system of vertebrates.High doses of several alkylphenols, including 4- tert-octylphenol, have altered estrogenic effects, including sex hormone levels, estrus cycles, reproductive outcomes, neonatal sexual development, as well as impaired production of steroid hormone and testicular atrophy.

Environmental Fate

Studies have shown that 4t-OP will adsorb to sediments.

Purification Methods

Crystallise the phenol from n-hexane and/or distil it in a vacuum. [Beilstein 6 III 2051, 6 IV 3484.]

Toxicity evaluation

4t-OP has been shown to be an estrogen receptor (ER) agonist. Estrogenic effects of 4t-OP have been demonstrated in human cells, with 4t-OP displacing the natural estrogen 17b estradiol from its receptor, and 4t-OP inducing cell proliferation in estrogen-dependent cell proliferation assays. In vivo confirmation of 4t-OP’s estrogenicity has been confirmed with the uterotrophic assay.

InChI:InChI=1/C14H22O/c1-2-3-4-5-6-7-8-13-9-11-14(15)12-10-13/h9-12,15H,2-8H2,1H3

Synthetic route

2,4,4-trimethyl-1-pentene (107-39-1) + phenol (108-95-2) → 2-tert-octylphenol (3884-95-5) + tert-octylphenol (140-66-9)

Conditions	Yield
	A 91% B n/a
With copper(II) bis(trifluoromethanesulfonate) at 60℃; for 0.25h; Friedel-Crafts alkylation; Title compound not separated from byproducts;

4-(1,1,3,3-tetramethylbutyl)anisole (5413-23-0) → tert-octylphenol (140-66-9)

Conditions	Yield
With perhydrodibenzo-18-crown-6; toluene for 3h; Ambient temperature;	90%

N,N'-hexanediyldicarbamic acid di(4-(1,1,3,3-tetramethylbutyl)phenyl) ester (1266554-70-4) → tert-octylphenol (140-66-9) + Hexamethylene diisocyanate (822-06-0)

Conditions	Yield
at 220℃; under 9.75098 Torr; Large scale;	A n/a B 83%

2,4,4-trimethyl-1-pentene (107-39-1) + 2,4,4-trimethylpent-2-ene (107-40-4) + phenol (108-95-2) → tert-octylphenol (140-66-9)

Conditions	Yield
With GLC-SbF5 at 70℃; for 1h;	80%

phenyl-(1,1,3,3-tetramethyl-butyl)-ether (872823-89-7) → tert-octylphenol (140-66-9)

Conditions	Yield
at 250℃;
at 250℃;

4,4"-di-tert-octylphenylamine (42265-56-5) → tert-octylphenol (140-66-9)

Conditions	Yield
Diazotization;

2,4,4-trimethyl-1-pentene (107-39-1) + phenol (108-95-2) → tert-octylphenol (140-66-9)

Conditions	Yield
With sulfuric acid at 20 - 25℃;
With sulfuric acid; acetic acid at 15℃;
With hydrogenchloride at 80 - 85℃;

2,4,4-trimethyl-1-pentene (107-39-1) + phenol (108-95-2) → 2,4-bis(1,1,3,3-tetramethylbutyl)phenol (5806-72-4) + tert-octylphenol (140-66-9)

Conditions	Yield
With sulfuric acid at 65℃;
With indium(III) chloride; 1-butyl-3-methylimidazolium chloride at 100℃;	A 7.7 %Chromat. B 83 %Chromat.

2,4,4-trimethyl-2-pentanol (690-37-9) + phenol (108-95-2) → tert-octylphenol (140-66-9)

Conditions	Yield
With aluminium trichloride; Petroleum ether at 25 - 30℃;

2,4,4-trimethyl-1-pentene (107-39-1) + phenol (108-95-2) → 2,4-bis(1,1,3,3-tetramethylbutyl)phenol (5806-72-4) + 2-tert-octylphenol (3884-95-5) + tert-octylphenol (140-66-9)

Conditions	Yield
With aluminium(III) phenoxide at 120 - 125℃; for 20h;
With aluminium(III) phenoxide at 120 - 125℃;
With aluminium(III) phenoxide at 120 - 125℃; for 5h;

2,4,4-trimethylpent-2-ene (107-40-4) + phenol (108-95-2) → 2,4-bis(1,1,3,3-tetramethylbutyl)phenol (5806-72-4) + 2-tert-octylphenol (3884-95-5) + tert-octylphenol (140-66-9)

Conditions	Yield
With aluminium(III) phenoxide at 120 - 125℃; for 20h;
With aluminium(III) phenoxide at 120 - 125℃; for 5h;

4-[4-(1,1,3,3-Tetramethyl-butyl)-phenoxycarbonylmethyl]-benzoic acid → 4-(carboxymethyl)benzoic acid (501-89-3) + tert-octylphenol (140-66-9)

Conditions	Yield
With phosphate buffer In acetonitrile at 21℃; Rate constant; other buffer; different pH; also in the presence of amidine or molecularly imprinted polymers as catalysts;

phenol (108-95-2) + 4-halogen-2.2.4-trimethyl-pentane → tert-octylphenol (140-66-9)

Conditions	Yield
With potassium hydroxide at 75 - 180℃;

aluminium trichloride (7446-70-0) + 2,4,4-trimethyl-2-pentanol (690-37-9) + phenol (108-95-2) + petroleum ether → tert-octylphenol (140-66-9)

Conditions	Yield
at 25 - 30℃;

2,4,4-trimethyl-2-pentanol (690-37-9) → tert-octylphenol (140-66-9)

Conditions	Yield
Multi-step reaction with 4 steps 1: AlCl3; petroleum ether / -10 °C 2: HNO3 3: tin; aqueous hydrochloric acid 4: Diazotization View Scheme

2-chloro-2,4,4-trimethylpentane (6111-88-2) → tert-octylphenol (140-66-9)

Conditions	Yield
Multi-step reaction with 2 steps 1: ethanol 2: 250 °C View Scheme

(1,1,3,3-tetramethyl-butyl)-benzene (35293-37-9) → tert-octylphenol (140-66-9)

Conditions	Yield
Multi-step reaction with 3 steps 1: HNO3 2: tin; aqueous hydrochloric acid 3: Diazotization View Scheme

1-nitro-4-(1,1,3,3-tetramethyl-butyl)-benzene (748815-18-1) → tert-octylphenol (140-66-9)

Conditions	Yield
Multi-step reaction with 2 steps 1: tin; aqueous hydrochloric acid 2: Diazotization View Scheme

sodium phenoxide (139-02-6) → tert-octylphenol (140-66-9)

Conditions	Yield
Multi-step reaction with 2 steps 1: ethanol 2: 250 °C View Scheme

benzene (71-43-2) → tert-octylphenol (140-66-9)

Conditions	Yield
Multi-step reaction with 4 steps 1: AlCl3; petroleum ether / -10 °C 2: HNO3 3: tin; aqueous hydrochloric acid 4: Diazotization View Scheme

2,4,4-trimethyl-1-pentene (107-39-1) + phenol (108-95-2) → 2,4-bis(1,1,3,3-tetramethylbutyl)phenol (5806-72-4) + 2-tert-octylphenol (3884-95-5) + tert-octylphenol (140-66-9) + 2-(1,1-dimethylethyl)-4-(1,1,3,3-tetramethylbutyl)phenol

Conditions	Yield
1-butyl-3-methylimidazolium heptachlorodiindate (III) at 80℃; for 2h; Product distribution / selectivity; In ionic liquid;

tert-octylphenol (140-66-9) → 2-bromo-4-(1,1,3,3-tetramethylbutyl)phenol (57835-35-5)

Conditions	Yield
With bromine In water at 70℃; for 2h;	100%
With bromine at 85℃;

Diethyl phosphonate (762-04-9, 123-22-8) + tert-octylphenol (140-66-9) → phosphoric acid diethyl ester 4-(1,1,3,3-tetramethyl-butyl)-phenyl ester

Conditions	Yield
With triethylamine In tetrachloromethane	100%

potassium carbonate (584-08-7) + tert-octylphenol (140-66-9) + 4-Fluoronitrobenzene (350-46-9) → 4-[4-(1,1,3,3-Tetramethyl-butyl)-phenoxy]-nitrobenzene

Conditions	Yield
In N-methyl-acetamide	100%

tert-octylphenol (140-66-9) + 4-Fluoronitrobenzene (350-46-9) → 4-[4-(1,1,3,3-Tetramethyl-butyl)-phenoxy]-nitrobenzene

Conditions	Yield
With potassium carbonate In N,N-dimethyl-formamide for 24h; Heating / reflux;	100%

trimethanolato(pentamethylcyclopentadienyl)titanium(IV) + tert-octylphenol (140-66-9) → Cp*Ti(4-t-octylphenolate)3

Conditions	Yield
In toluene for 12h; Reflux;	100%

(pentamethylcyclopentadienyl)titanium(IV)triisopropoxide (121281-69-4) + tert-octylphenol (140-66-9) → Cp*Ti(4-t-octylphenolate)3

Conditions	Yield
In toluene for 12h; Reflux;	100%

trifluoromethylsulfonic anhydride (358-23-6) + tert-octylphenol (140-66-9) → 4-tert-octyl-1-trifluoromethanesulfonyloxybenzene (849907-81-9)

Conditions	Yield
Stage #1: tert-octylphenol With triethylamine In dichloromethane at 0℃; for 0.166667h; Stage #2: trifluoromethylsulfonic anhydride In dichloromethane at 0 - 20℃;	99.6%
With pyridine at 0 - 20℃;	98%
With dmap In dichloromethane at 0℃; for 2h;	66%

1,6-hexamethylene diurea (2188-09-2) + tert-octylphenol (140-66-9) → N,N’-hexanediyl-di((4-tert-octylphenyl)carbamate)

Conditions	Yield
at 100 - 240℃; for 0.966667h; Inert atmosphere;	99%
With ammonia In toluene at 220℃; Solvent;	44%

tert-octylphenol (140-66-9) → 2-chloro-4-(1,1,3,3-tetramethylbutyl)phenol (17199-24-5)

Conditions	Yield
With chlorine In tetrachloromethane at 20℃; for 4h;	96%
With chlorine at 90 - 110℃;
With sulfuryl dichloride
With chlorine at 90 - 110℃;

tert-octylphenol (140-66-9) → 4-tert-octyl-1-trifluoromethanesulfonyloxybenzene (849907-81-9)

Conditions	Yield
With pyridine; trifluoromethylsulfonic anhydride at 0 - 20℃; Inert atmosphere;	96%

1,6-Hexanediamine (124-09-4) + tert-octylphenol (140-66-9) + urea (57-13-6) → N,N'-hexanediyldicarbamic acid di(4-(1,1,3,3-tetramethylbutyl)phenyl) ester (1266554-70-4)

Conditions	Yield
at 120℃; under 75.0075 Torr; Concentration; Large scale;	96%
at 240℃; under 150.015 Torr; Industrial scale;	95%

tert-octylphenol (140-66-9) + N,N'-bis(4'-bromophenyl)-1,6,7,12-tetrachloroperylene-3,4,9,10-tetracarboxdiimide → N,N'-bis(4'-bromophenyl)-1,6,7,12-tetra[4-(1,1,3,3-tetramethylbutyl)phenoxy]perylene-3,4,9,10-tetracarboxdiimide (344454-74-6)

Conditions	Yield
With potassium carbonate In 1-methyl-pyrrolidin-2-one at 80℃; for 24h;	95%

2-chloro-5-nitropyridine (4548-45-2) + tert-octylphenol (140-66-9) → 5-nitro-2-(4-(2,4,4-trimethylpentan-2-yl)phenoxy)pyridine

Conditions	Yield
With potassium carbonate In dimethyl sulfoxide at 40℃; for 28h;	95%

tert-octylphenol (140-66-9) + acryloyl chloride (814-68-6) → 4-(1,1,3,3-tetramethylbutyl)phenyl acrylate

Conditions	Yield
With triethylamine In dichloromethane at 0℃; for 0.5h;	94.2%

formaldehyd (50-00-0) + tert-octylphenol (140-66-9) → 2-hydroxy-5-(1,1,3,3-tetramethylbutyl)benzaldehyde (10581-28-9)

Conditions	Yield
With triethylamine; magnesium chloride In tetrahydrofuran for 12h; Inert atmosphere; Reflux;	94%
With triethylamine; magnesium chloride In tetrahydrofuran for 24h; Inert atmosphere; Reflux;	78%
Stage #1: tert-octylphenol With ethylmagnesium bromide In diethyl ether at 20℃; Stage #2: formaldehyd With N,N,N,N,N,N-hexamethylphosphoric triamide In benzene Heating;	74.5%
With tributyl-amine; tin(IV) chloride 1.) toluene, 1 min, 20 deg C, 2.) toluene, reflux, 20 h; Yield given. Multistep reaction;

polytetrafluoroethylene (116-14-3) + tert-octylphenol (140-66-9) → 1,1,3,3-tetramethyl-1-[p-(1,1,2,2-tetrafluoroethoxy)phenyl]butane

Conditions	Yield
With potassium hydroxide In dimethyl sulfoxide at 60℃; for 5h; Addition;	94%
With potassium hydroxide In 1,1,2-Trichloro-1,2,2-trifluoroethane; dimethyl sulfoxide at 60℃; under 2206.52 - 2942.03 Torr; Addition;	94%

2-nitrobenzenediazonium chloride (119-66-4) + tert-octylphenol (140-66-9) → 2-(2'-hydroxy-5'-tert-octylphenyl)nitrodiazobenzene (51656-57-6)

Conditions	Yield
With sodium hydroxide In ethanol; water at 10℃; for 3h; pH=7.2-7.8;	94%

tert-octylphenol (140-66-9) → 1-(2,2,3,3-tetrafluoropropoxy)-3-(4-tert-octylphenoxy)-2-propanol (301537-23-5)

Conditions	Yield
	93%

tert-octylphenol (140-66-9) + allyl bromide (106-95-6) → 1-allyloxy-4-(2,4,4-trimethylpentan-2-yl)benzene (61103-72-8)

Conditions	Yield
Stage #1: tert-octylphenol With potassium carbonate; potassium iodide In acetone for 1h; Inert atmosphere; Reflux; Stage #2: allyl bromide In acetone for 40h; Reflux;	92%

5-(2,5-dimethylphenyl)-1,2-oxazole-3-carbonyl chloride + tert-octylphenol (140-66-9) → 4-(2,4,4-trimethylpentan-2-yl)phenyl 5-(2,5-dimethylphenyl)-1,2-oxazole-3-carboxylate

Conditions	Yield
With triethylamine In diethyl ether at 23℃; for 5h;	92%

3-(chloromethyl)-5-phenylisoxazole (14731-10-3) + tert-octylphenol (140-66-9) → 3-{[4-(2,4,4-trimethylpentan-2-yl)phenoxy]methyl}-5-phenylisoxazole

Conditions	Yield
With potassium carbonate In ethanol for 120h; Reflux; Inert atmosphere;	92%

5-(4-methylphenyl)-3-(chloromethyl)isoxazole + tert-octylphenol (140-66-9) → 5-(4-methylphenyl)-3-{[4-(2,4,4-trimethylpentan-2-yl)-phenoxy]methyl}isoxazole

Conditions	Yield
With potassium carbonate In ethanol for 120h; Reflux; Inert atmosphere;	91%

2-nitro-aniline (88-74-4) + tert-octylphenol (140-66-9) → Cyasorb UV 5411 (3147-75-9)

Conditions	Yield
Stage #1: 2-nitro-aniline With sulfuric acid In water for 0.333333h; Stage #2: With sodium nitrite In water at 0℃; for 2.5h; Cooling with ice; Stage #3: tert-octylphenol Further stages;	90.01%
Multi-step reaction with 2 steps 1.1: sodium nitrite; hydrogenchloride / water / -15 - 5 °C 1.2: 2 h / 0 °C 2.1: zinc; sodium hydroxide / water; Petroleum ether / 5 h / 50 °C View Scheme

tert-octylphenol (140-66-9) + 2-chloro-ethanol (107-07-3) → 2-[4-(2,4,4-trimethylpentan-2-yl)phenoxy]ethanol (2315-67-5)

Conditions	Yield
With N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate In N,N-dimethyl-formamide for 4 - 7h; Heating / reflux;	90%
With potassium carbonate; potassium iodide In N,N-dimethyl-formamide for 8h; Reflux;	77%
With sodium hydroxide at 25 - 40℃;
With sodium hydroxide; toluene; butan-1-ol Entfernen des entstehenden Wassers;
With sodium hydroxide at 25 - 40℃;

Quinoline N-oxide (1613-37-2) + tert-octylphenol (140-66-9) → quinoline N-oxide and 4-(1,1,3,3-tetramethylbutyl)phenol 1:1 complex

Conditions	Yield
In toluene at 20 - 110℃; Product distribution; Further Variations:; Solvents;	90%

5-(4-methylphenyl)-1,2-oxazole-3-carbonyl chloride (88958-29-6) + tert-octylphenol (140-66-9) → 4-(2,4,4-trimethylpentan-2-yl)phenyl 5-(4-methylphenyl)-1,2-oxazole-3-carboxylate

Conditions	Yield
With triethylamine In diethyl ether at 23℃; for 5h;	90%

tert-octylphenol (140-66-9) → bis<4-(1,1,3,3-tetramethylbutyl)phenyl> hydrogen phosphate (1758-45-8) + tri[4-(1,1,3,3-tetra-methylbutyl)phenyl] phosphate (222552-35-4)

Conditions	Yield
With pyridine; trichlorophosphate In neat (no solvent) at 97℃; for 0.0333333h; Microwave irradiation;	A n/a B 89%

C24H9BClI3N6 (182561-78-0, 301669-53-4, 301669-55-6) + tert-octylphenol (140-66-9) → C38H30BI3N6O (1235556-55-4)

Conditions	Yield
In toluene for 10h; Reflux;	88%

Upstream product

• 107-39-1 2,4,4-trimethyl-1-pentene 
• 108-95-2 phenol 
• 690-37-9 2,4,4-trimethyl-2-pentanol 
• 107-40-4 2,4,4-trimethylpent-2-ene 
• 5413-23-0 4-(1,1,3,3-tetramethylbutyl)anisole 
• 7446-70-0 aluminium trichloride 
• 71-43-2 benzene 
• 75-65-0 tert-butyl alcohol 
• 872823-89-7 phenyl-(1,1,3,3-tetramethyl-butyl)-ether 
• 1266554-70-4 N,N'-hexanediyldicarbamic acid di(4-(1,1,3,3-tetramethylbutyl)phenyl) ester 
• 139-02-6 sodium phenoxide 
• 748815-18-1 1-nitro-4-(1,1,3,3-tetramethyl-butyl)-benzene 
• 35293-37-9 (1,1,3,3-tetramethyl-butyl)-benzene 
• 6111-88-2 2-chloro-2,4,4-trimethylpentane 

Downstream Products

• 2315-67-5 2-[4-(2,4,4-trimethylpentan-2-yl)phenoxy]ethanol 
• 5414-83-5 2-(piperidin-1-ylmethyl)-4-(2,4,4-trimethylpentan-2-yl)phenol 
• 25543-98-0 2-Morpholinomethyl-4-(1,1,3,3-tetramethyl-butyl)-phenol 
• 5454-15-9 1-acetoxy-4-(1,1,3,3-tetramethyl-butyl)-benzene 
• 37693-05-3 2-Benzyl-4-(1,1,3,3-tetramethyl-butyl)-phenol 
• 110875-85-9 GRI 511254 
• 37693-06-4 2-(4-chloro-benzyl)-4-(1,1,3,3-tetramethyl-butyl)-phenol 
• 13402-97-6 2-(4-(2,4,4-trimethylpentan-2-yl)phenoxy)acetic acid 
• 67025-22-3 1-[2-(2-chloro-ethoxy)-ethoxy]-2-[4-(1,1,3,3-tetramethyl-butyl)-phenoxy]-ethane 
• 27725-17-3 4,4'-bis-(1,1,3,3-tetramethyl-butyl)-2,2'-methanediyl-di-phenol 
• 5568-04-7 4-tert-octyl-2,6-bis(hydroxymethyl)phenol 
• 62421-94-7 adipic acid bis-[4-(1,1,3,3-tetramethyl-butyl)-phenyl ester] 
• 10581-28-9 2-hydroxy-5-(2,4,4-trimethyl-2-pentyl)benzaldehyde 
• 857578-97-3 2-(β-chloro-isopropoxy)-1-[4-(1,1,3,3-tetramethyl-butyl)-phenoxy]-propane 

Related news

Biodegradation of the endocrine disrupter 4-tert-Octylphenol (cas 140-66-9) by the yeast strain Candida rugopelliculosa RRKY5 via phenolic ring hydroxylation and alkyl chain oxidation pathways09/30/2019

4-(1,1,3,3-tetramethylbutane)-phenol (4-tert-OP) is one of the most prevalent endocrine disrupting pollutants. Information about bioremediation of 4-tert-OP remains limited, and no study has been reported on the mechanism of 4-tert-OP degradation by yeasts. The yeast Candida rugopelliculosa RRKY...detailed

Effect of waterborne exposure to 4-tert-Octylphenol (cas 140-66-9) and 17β-estradiol on smoltification and downstream migration in Atlantic salmon, Salmo salar09/29/2019

Groups of Atlantic salmon parr (November, Exp. 1) or pre-smolts (March, Exp. 2) were exposed to estradiol-17β (E2 conc.: nominal 500ngl −1 /actual 8–16ngl −1 ) and two doses of tert-octylphenol (OP: nominal 25μgl −1 /actual 4.5–6.5μgl −1 and OP: nominal 100μ...detailed

Effects of 4-tert-Octylphenol (cas 140-66-9) on Xenopus tropicalis in a long term exposure10/01/2019

Endocrine disrupting chemicals that activate the estrogen receptor are routinely detected in the environment and are a concern for the health of both exposed humans and indigenous wildlife. We exposed the western clawed frog (Xenopus tropicalis) to the weak estrogen octylphenol from Nieuwkoop–F...detailed

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Metal inflates and metal triflimidates are shown to catalyse efficiently the Friedel-Crafts alkylation of phenol with alkenes. Bismuth, copper and scandium triflates lead to very good yields with excellent para-selectivities.

Dissolving metal reduction with crown ether --- reductive demethylation of mono-, di- and trimethoxybenzene derivatives with toluene radical anion

Toluene radical anion generated from potassium metal and toluene with the assistance of crown ether has been proved effective for reductive demethylation of methoxybenzene derivatives.

Lubricant stabilizers

Phenol sulfides, disulfides, polysulfides and oligomers thereof when reacted with alkyl vinyl ethers provide addition products substantially comprised of novel acetal derivatives which are effective oxidation inhibitors when incorporated into organic media normally susceptible to oxidative degradation.

Process for the production of 2-aryl-2H-benzotriazoles

A process for the production of 2-aryl-2H-benzotriazoles comprises reducing and cyclizing the corresponding o-nitroazobenzenes with hydrogen at a temperature in the range of about 20° C. to about 100° C. and at a pressure in the range of about 15 psia (1 atmosphere) to about 1000 psia (66 atmospheres) in an alkaline medium at a pH over 10 in the presence of a nickel catalyst, preferably molybdenum-promoted Raney nickel. High yields of pure product are obtained directly with a concomitant reduction of undesired by-product and a reduction in effluent pollution problems.