- Identification of novel PARP-1 inhibitors: Drug design, synthesis and biological evaluation
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A series of AG014699 derivatives containing a novel scaffold of 2,3-dihydro-1H-[1,2]diazepino[4,5,6-cd]indole-1,4(6H)-dione were synthesized and evaluated for their inhibitory activities toward PARP-1 enzyme and two cell lines, MCF-7 cells and the BRCA1-deficient MDA-MB-436 cells. Our results demonstrated that of all AG014699 derivatives synthesized in this work, compounds 6 and 7 showed strong PARP-1 inhibitory activity (IC50 = 3.5 nM and 2.4 nM, respectively), only four and three times less potent than AG014699. Compound 6 also had significantly cell inhibitory activity against both MCF-7 cells (CC50 = 25.8 μM) and the BRCA1-deficient MDA-MB-436 cells (CC50 = 5.4 μM), nearly as good as AG014699, indicating that it can be a promising compound for further evaluation.
- Xie, Zhouling,Zhou, Youli,Zhao, Wei,Jiao, He,Chen, Yu,Yang, Yong,Li, Zhiyu
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supporting information
p. 4557 - 4561
(2015/10/12)
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- Discovery of potent, selective chymase inhibitors via fragment linking strategies
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Chymase plays an important and diverse role in the homeostasis of a number of cardiovascular processes. Herein, we describe the identification of potent, selective chymase inhibitors, developed using fragment-based, structure-guided linking and optimizati
- Taylor, Steven J.,Padyana, Anil K.,Abeywardane, Asitha,Liang, Shuang,Hao, Ming-Hong,De Lombaert, Stéphane,Proudfoot, John,Farmer, Bennett S.,Li, Xiang,Collins, Brandon,Martin, Leslie,Albaugh, Daniel R.,Hill-Drzewi, Melissa,Pullen, Steven S.,Takahashi, Hidenori
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p. 4465 - 4481
(2013/07/19)
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