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910297-71-1

Des-6-[4-(2-hydroxyethyl)-1-piperazinyl]-6-chloro Dasatinib is a chemical compound that serves as an intermediate in the preparation of Dasatinib metabolite. It is a derivative of Dasatinib, a potent tyrosine kinase inhibitor with potential applications in the treatment of various cancers and immune diseases.
Used in Pharmaceutical Industry:
Des-6-[4-(2-hydroxyethyl)-1-piperazinyl]-6-chloro Dasatinib is used as an intermediate in the synthesis of Dasatinib, a medication for the treatment of cancers and immune diseases. Its role in the synthesis process is crucial for the development of effective therapies targeting specific tyrosine kinases involved in these conditions.
Used in Cancer Treatment:
Des-6-[4-(2-hydroxyethyl)-1-piperazinyl]-6-chloro Dasatinib is used as a precursor in the preparation of Dasatinib, which is employed as an anticancer agent. Dasatinib targets various tyrosine kinases, including BCR-ABL, SRC family kinases, and KIT, making it a valuable treatment option for patients with chronic myeloid leukemia, Philadelphia chromosome-positive acute lymphoblastic leukemia, and other malignancies.
Used in Immune Disease Treatment:
Des-6-[4-(2-hydroxyethyl)-1-piperazinyl]-6-chloro Dasatinib is used as a precursor in the synthesis of Dasatinib, which has potential applications in the treatment of immune diseases. Dasatinib's ability to inhibit SRC family kinases, which play a role in immune cell activation and function, makes it a candidate for the treatment of autoimmune disorders and other immune-related conditions.
Used in COVID-19 Research:
Des-6-[4-(2-hydroxyethyl)-1-piperazinyl]-6-chloro Dasatinib is used as a COVID-19-related research product. Its role in the synthesis of Dasatinib, which has been investigated for its potential to inhibit viral entry and replication in SARS-CoV-2, the virus responsible for COVID-19, makes it an important compound in the development of therapeutic strategies against the pandemic.

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  • Des-6-[4-(2-hydroxyethyl)-1-piperazinyl]-6-chloro Dasatinib

    Cas No: 910297-71-1

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  • 910297-71-1 Structure

  • Basic information

    1. Product Name: Des-6-[4-(2-hydroxyethyl)-1-piperazinyl]-6-chloro Dasatinib
    2. Synonyms: Des-6-[4-(2-hydroxyethyl)-1-piperazinyl]-6-chloro Dasatinib
    3. CAS NO:910297-71-1
    4. Molecular Formula: C16H13Cl2N5O2S
    5. Molecular Weight: 410.27772
    6. EINECS: N/A
    7. Product Categories: Intermediates & Fine Chemicals;Pharmaceuticals;Tyrosine Kinase Inhibitors
    8. Mol File: 910297-71-1.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.593±0.06 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: Refrigerator
    8. Solubility: DMSO (Slightly), Methanol (Slightly)
    9. PKA: 10.69±0.70(Predicted)
    10. CAS DataBase Reference: Des-6-[4-(2-hydroxyethyl)-1-piperazinyl]-6-chloro Dasatinib(CAS DataBase Reference)
    11. NIST Chemistry Reference: Des-6-[4-(2-hydroxyethyl)-1-piperazinyl]-6-chloro Dasatinib(910297-71-1)
    12. EPA Substance Registry System: Des-6-[4-(2-hydroxyethyl)-1-piperazinyl]-6-chloro Dasatinib(910297-71-1)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 910297-71-1(Hazardous Substances Data)

910297-71-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 910297-71-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,1,0,2,9 and 7 respectively; the second part has 2 digits, 7 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 910297-71:
(8*9)+(7*1)+(6*0)+(5*2)+(4*9)+(3*7)+(2*7)+(1*1)=161
161 % 10 = 1
So 910297-71-1 is a valid CAS Registry Number.

910297-71-1Downstream Products

910297-71-1Relevant articles and documents

PROCESS FOR PREPARING N-(2-CHLORO-6-METHYLPHENYL)-2-[[6-[4-(2-HYDROXYETHYL)-1-PIPERAZINYL]-2-METHYL-4-PYRIMIDINYL]AMINO] -5-THIAZOLECARBOXAMIDE AND RELATED METABOLITES THEREOF

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Page/Page column 24; 26; 27, (2010/11/28)

The present invention is directed to process for the preparation of metabolites as well as the parent compound of N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl] amino]-5-thiazolecarboxamide, the compound of formula (I).

'N-(2-chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamides metabolites

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Page/Page column 35, (2008/06/13)

The present invention is directed to metabolites of ′N-(2-Chloro-6-methylphenyl)-2-[[6-[4-(2-hydroxyethyl)-1-piperazinyl]-2-methyl-4-pyrimidinyl]amino]-5-thiazolecarboxamide, the compound of formula (I), pharmaceutical compositions thereof, and to methods

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