- Aerobic intramolecular carbon-hydrogen bond oxidation promoted by Cu(i) complexes
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The oxidation of C-H bonds by copper centres in enzymes with molecular oxygen takes place in nature under ambient conditions. Herein we report a similar transformation in which under ambient pressure and temperature (1 atm, 25 °C) the complex TpMsCu(THF)
- álvarez, Eleuterio,álvarez, Mariá,Fructos, Manuel R.,Lledós, Agustí,Molina, Francisco,Pérez, Pedro J.,Sodupe, Mariona,Urbano, Juan
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supporting information
p. 14647 - 14655
(2020/11/07)
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- Synthesis and biological evaluation of N-(4-phenylthiazol-2-yl)cinnamamide derivatives as novel potential anti-tumor agents
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In this study, a series of novel N-(4-phenylthiazol-2-yl)cinnamamide derivatives (7a-8n) were synthesized and evaluated for their anti-proliferative activities in vitro by MTT assay and a possible antitumor mechanism was also explored. SAR analysis showed that steric effects played an important role on the anti-tumor activity. The most potent analogue 8f showed excellent inhibitions on the K562, Bel7402, A549 and Jurkat cells ranging from sub-micromolar to nanomolar concentration. Compound 8f inhibited Jurkat cells with an IC50 value of 0.035 μM with no apparent toxicity in different non-cancerous cells. Furthermore, it was suggested that the possible mechanism of 8f might be associated with inducing cancer cell apoptosis following flow cytometer analysis and Hoechst 33358 staining assays.
- Luo, Yong,Zhu, Yongxia,Ran, Kai,Liu, Zhihao,Wang, Ningyu,Feng, Qiang,Zeng, Jun,Zhang, Lidan,He, Bing,Ye, Tinghong,Zhu, Shirui,Qiu, Xiaolong,Yu, Luoting
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supporting information
p. 1036 - 1042
(2015/06/25)
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- P-HYDROXY PHENONE DERIVATIVES AND THE USE THEREOF
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p-Hydroxy phenone derivatives of the general formula I STR1 where R 1, R 2 and R 3 are identical or different and are methyl, chlorine, bromine and hydrogen, but R 1, R 2 and R 3 are not all H,R 4 and R 5 are identical or different and are H, C 1-C 4-alkyl, or OR 6, but R 4 and R 5 are not both H,X is a--CH=CH--,--CH. sub.2 CH 2 or--CH. sub.2--bridge,Y is a straight-chain or branched, saturated or unsaturated C 1-C 4 bridge, and Z is NR 6 R 7, where R 6 and R 7 are, independently of one another, hydrogen or C 1-4-alkyl, or Z is a 5-or 6-membered ring with a nitrogen atom in the 1 position and, where appropriate, additionally a second N atom or an O or S atom, the second N atom being substituted by R 7, as well as the physiologically tolerated salts thereof,are used to prepare drugs antiarrhythmic of Vaughan-Williams class III.
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