910875-39-7

Basic information

• Product Name: 3-Phenylpiperidin-4-one monohydrochloride
• Synonyms: 3-Phenylpiperidin-4-one monohydrochloride;3-phenylpiperidin-4-one hydrochloride
• CAS NO: 910875-39-7
• Molecular Formula: C₁₁H₁₃NO*ClH
• Molecular Weight: 211.68796
• Mol File: 910875-39-7.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-Phenylpiperidin-4-one monohydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Phenylpiperidin-4-one monohydrochloride(910875-39-7)
• EPA Substance Registry System: 3-Phenylpiperidin-4-one monohydrochloride(910875-39-7)

Safety Data

• Hazardous Substances Data: 910875-39-7(Hazardous Substances Data)

Usage

Uses

Used in Chemical and Pharmaceutical Research:
3-Phenylpiperidin-4-one monohydrochloride is used as a building block in the synthesis of various compounds, particularly in the development of new drugs. Its unique structure and properties make it a valuable component in the creation of innovative pharmaceuticals.
Used in Pain Relief Medication:
3-Phenylpiperidin-4-one monohydrochloride is used as an analgesic agent due to its pain-relief properties. It has been the subject of interest for its potential as a medication to alleviate pain and improve the quality of life for patients suffering from various conditions.
Used in Central Nervous System Research:
3-Phenylpiperidin-4-one monohydrochloride is used as a dopamine receptor antagonist, making it a target for studying its effects on the central nervous system. This research can lead to a better understanding of neurological disorders and the development of more effective treatments.

Upstream product

• 910875-38-6 ethyl 3-(2-ethoxycarbonylethylamino)-2-phenylpropionate phosphate 
• 446302-83-6 1-N-benzyl-3-phenyl-4-piperidone 
• 1384264-55-4 C₂₁H₂₃NO₃ 
• 1345345-81-4 1-benzyl-3-phenyl-4-piperidone hydrochloride 

Downstream Products

• 913092-75-8 N-[2-oxo-2-(4-oxo-3-phenylpiperidin-1-yl)ethyl]acetamide 
• 880135-38-6 tert-butyl (3R,4S)-4-amino-3-phenylpiperidine-1-carboxylate 
• 913252-06-9 tert-butyl (3S,4R)-4-amino-3-phenylpiperidine-1-carboxylate 

Relevant articles and documents

Design, structure-activity relationship, and highly efficient asymmetric synthesis of 3-phenyl-4-benzylaminopiperidine derivatives as novel neurokinin-1 receptor antagonists

We synthesized a series of novel 3-phenyl-4-benzylaminopiperidine derivatives that were identified as potent tachykinin NK1 receptor antagonists by structural modification of the 3-benzhydrylpiperidone derivative through high-throughput screening. N-{2-[(3R,4S)-4-({2-Methoxy-5-[5-(trifluoromethyl)- 1Htetrazol-1-yl]benzyl}amino)-3-phenyl-1-piperidinyl]-2-oxoethyl}acetamide ((+)-39) was found to be one of the most potent tachykinin NK1 receptor antagonists with high metabolic stability. Highly efficient asymmetric synthesis of (+)-39 was achieved via dynamic kinetic resolution.

Piperidine derivative crystal, process for producing the same, and use

The present invention provides a piperidine derivative having antagonistic action for tachykinin receptors and the like, a crystal thereof, and an agent for the prophylaxis or treatment of diseases including lower urinary tract disease and the like, which contains the derivative. Specifically, the present invention provides an optically active compound represented by the formula (I): wherein each symbol is as defined in the specification, and a salt thereof.