3-Phenylpiperidin-4-one monohydrochloride

Base Information

• Chemical Name: 3-Phenylpiperidin-4-one monohydrochloride
• CAS No.: 910875-39-7
• Molecular Formula: C11H13NO.ClH
• Molecular Weight: 211.691
• Hs Code.: 2933399090
• Mol file: 910875-39-7.mol

Synonyms:3-phenylpiperidin-4-one monohydrochloride;2,6-Piperazinedione,3-phenyl;(+-)-3-Phenyl-piperazin-2,6-dion;2,6-Piperazinedione,3-phenyl-(6CI);3-phenyl-piperazine-2,6-dione;3,5-Dioxo-2-phenylpiperazine;4-oxo-3-phenylpiperidine hydrochloride;

Chemical Property of 3-Phenylpiperidin-4-one monohydrochloride

Chemical Property:

• PSA: 29.10000
• LogP: 2.46340

Purity/Quality:

≥95% ^*data from raw suppliers

3-Phenylpiperidin-4-onehydrochloride 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Phenylpiperidin-4-one monohydrochloride

There total 4 articles about 3-Phenylpiperidin-4-one monohydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-benzyl-3-phenyl-4-piperidone hydrochloride (1345345-81-4) → 4-oxo-3-phenylpiperidine hydrochloride (910875-39-7)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 55 ℃; for 2h; under 3800.26 Torr;

DOI:10.1016/j.bmc.2011.08.070

Reference yield:

ethyl 3-(2-ethoxycarbonylethylamino)-2-phenylpropionate phosphate (910875-38-6) → 4-oxo-3-phenylpiperidine hydrochloride (910875-39-7)

Guidance literature:

ethyl 3-(2-ethoxycarbonylethylamino)-2-phenylpropionate phosphate; With sodium t-butanolate; In tetrahydrofuran; at 0 - 35 ℃; for 3.5h;

With water; In tetrahydrofuran; at 80 ℃; for 5h;

With hydrogenchloride; In ethanol; ethyl acetate; at 0 - 80 ℃; for 5h;

Reference yield:

1-N-benzyl-3-phenyl-4-piperidone (446302-83-6) → 4-oxo-3-phenylpiperidine hydrochloride (910875-39-7)

Guidance literature:

Multi-step reaction with 2 steps

1: hydrogenchloride / ethyl acetate

2: palladium 10% on activated carbon; hydrogen / methanol / 2 h / 55 °C / 3800.26 Torr

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; In methanol; ethyl acetate;

DOI:10.1016/j.bmc.2011.08.070

upstream raw materials:

ethyl 3-(2-ethoxycarbonylethylamino)-2-phenylpropionate phosphate

1-N-benzyl-3-phenyl-4-piperidone

C₂₁H₂₃NO₃

1-benzyl-3-phenyl-4-piperidone hydrochloride

Downstream raw materials:

N-[2-oxo-2-(4-oxo-3-phenylpiperidin-1-yl)ethyl]acetamide