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3-chloro-1H-pyrazol-5-amine, also known as 3-chloro-5-aminopyrazole, is a chlorinated derivative of pyrazol-5-amine with the molecular formula C3H5ClN4. It is a white to off-white crystalline powder that serves as a versatile building block in the pharmaceutical industry for the synthesis of various drug molecules. This chemical compound has a melting point of 219-221°C and a molecular weight of 136.55 g/mol. Its potential biological activities make it a promising candidate for the development of new drugs, but it should be handled with care due to its possible hazardous properties.

916211-79-5

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916211-79-5 Usage

Uses

Used in Pharmaceutical Industry:
3-chloro-1H-pyrazol-5-amine is used as a chemical intermediate for the synthesis of a wide range of pharmaceuticals and agrochemicals. Its versatility allows for the creation of various drug molecules, contributing to the development of new treatments and therapies.
Used in Drug Development:
3-chloro-1H-pyrazol-5-amine is used as a starting material in the development of new drugs due to its potential biological activities. Its unique structure and properties make it a valuable component in the design and synthesis of innovative pharmaceutical compounds.
Used in Agrochemical Production:
In addition to its applications in the pharmaceutical industry, 3-chloro-1H-pyrazol-5-amine is also used as a building block in the production of agrochemicals. Its role in creating effective and targeted agrochemicals contributes to advancements in agriculture and crop protection.

Check Digit Verification of cas no

The CAS Registry Mumber 916211-79-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 9,1,6,2,1 and 1 respectively; the second part has 2 digits, 7 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 916211-79:
(8*9)+(7*1)+(6*6)+(5*2)+(4*1)+(3*1)+(2*7)+(1*9)=155
155 % 10 = 5
So 916211-79-5 is a valid CAS Registry Number.

916211-79-5Downstream Products

916211-79-5Relevant articles and documents

COMPOUNDS FOR MALT1 DEGRADATION

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Paragraph 00296; 00300, (2018/05/24)

Provided herein are bifunctional compounds that inhibit MALTl and/or promote targeted ubiquitination for the degradation of MALTl. In particular, provided are compounds that can bind MALTl, a protein whose activity is responsible for constitutive NF-KB signaling in certain cancers (e.g., activated B-cell diffuse large B-cell lymphoma (ABC-DLBCL)), and can assist in its degradation by recruiting an E3 ubiquitin ligase (e.g., Cereblon, VHL), which can ubiquitinate MALTl, marking it for proteasome degradation. Also provided are pharmaceutical compositions comprising the bifunctional compounds, methods of treating cancer with the bifunctional compounds, methods of promoting the degradation of MALTl, and methods of binding E3 ubiquitin ligase activity in a subject by administering a compound or composition described herein.

Discovery of ((S)-5-(methoxymethyl)-7-(1-methyl-1 H -indol-2-yl)-2- (trifluoromethyl)-4,7-dihydropyrazolo[1,5- a ]pyrimidin-6-yl)((S)-2-(3- methylisoxazol-5-yl)pyrrolidin-1-yl)methanone as a potent and selective I Kur inhibitor

Finlay, Heather J.,Lloyd, John,Vaccaro, Wayne,Kover, Alexander,Yan, Lin,Bhave, Gauri,Prol, Joseph,Huynh, Tram,Bhandaru, Rao,Caringal, Yolanda,Dimarco, John,Gan, Jinping,Harper, Tim,Huang, Christine,Conder, Mary Lee,Sun, Huabin,Levesque, Paul,Blanar, Michael,Atwal, Karnail,Wexler, Ruth

experimental part, p. 3036 - 3048 (2012/06/01)

Previously disclosed dihydropyrazolopyrimidines are potent and selective blockers of IKur current. A potential liability with this chemotype is the formation of a reactive metabolite which demonstrated covalent binding to protein in vitro. When substituted at the 2 or 3 position, this template yielded potent IKur inhibitors, with selectivity over hERG which did not form reactive metabolites. Subsequent optimization for potency and PK properties lead to the discovery of ((S)-5-(methoxymethyl)-7-(1-methyl-1H-indol- 2-yl)-2-(trifluoromethyl)-4,7-dihydropyrazolo[1,5-a]pyrimidin-6-yl)((S) -2-(3-methylisoxazol-5-yl)pyrrolidin-1-yl)methanone (13j), with an acceptable PK profile in preclinical species and potent efficacy in the preclinical rabbit atrial effective refractory period (AERP) model.

HETEROBICYCLIC METALLOPROTEASE INHIBITORS

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Page/Page column 132-133, (2008/12/05)

The present invention relates generally to heterobicyclic containing pharmaceutical agents, and in particular, to heterobicyclic metalloprotease inhibitor compounds. More particularly, the present invention provides a new class of heterobicyclic metalloprotease inhibiting compounds that exhibit an increased potency in relation to currently known metalloprotease inhibitors.

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